posted
I've been on Methylene Blue and Rifampin for a month now.
Bartonella was always my most serious issue, Rifampin would get it under control, but I would experience rapid relapses when I went off medication.
With MB, the herxes simply haven't stopped. Whenever I take a dose of Rifampin and MB, several hours later, I'll experience a herx. That's never happened to me before. Certainly not for 30 straight days.
There are two forms of Bartonella, a growing and a stationary form. Conventional treatments, like Rifampin, can kill the active form, but do nothing for the stationary form. And then you have the issue of biofilms. With conventional treatments, you would never get well.
MB kills the stationary form though, and is effective at breaking down biofilms. If you combine it with Rifampin, you might actually defeat Bartonella.
It's possible I always had Bartonella, we had cats growing up, and it may have been the preexisting weakness that made my immune system so vulnerable. No way to know.
I do think this combination is effective, if only because I continue to experience herxes.
Another drug worth looking at is Nitroxoline, but it's not approved for use in the USA.
Posts: 146 | From Virginia | Registered: Mar 2010
| IP: Logged |
posted
Good point stressing on stationary phases, biofilms etc. I believe this doesn't get enough attention than it should.
This could be very well the reason why some people don't see improvement, are discouraged and maybe even question their treatment protocols.
Posts: 597 | From Massachusetts | Registered: Mar 2019
| IP: Logged |
I am very interested to hear how you get on as have lyme with bart and exploring all the different treatment options
Posts: 245 | From UK | Registered: Feb 2020
| IP: Logged |
posted
Hey Charles, how are you doing these days? Have you heard about Dr M using clarithromycin and rifabutin simultaneously? He's specialising in bart.
Posts: 2 | From UK | Registered: Feb 2021
| IP: Logged |
Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
I've heard some encouraging words on MB and Bartonella.
methylene blue was actually the first synthetic drug ever developed. it has since been largely superseded as a drug but still used in staining tissue for surgery and in microscopy.
Zhang et al recently rediscovered its ability to kill bartonella persister cells in their large bartonella drug screening study.
doses range from 50mg a day to 1000mg a day (was used for malaria at these high doses)
please use only pharmaceutical grade as heavy metals are a common impurity from the manufacturing process.
i have started at 25mg a day along with bart herbs ( MB must be used as a combination therapy - as it does not kill growing cells well - it is instead specific to persister cells)
i experienced mild to moderate herx like reactions when i added it to my bart herb regime - so its doing something
Posts: 245 | From UK | Registered: Feb 2020
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
![[Big Grin]](biggrin.gif)
Printer-friendly view of this topic