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» LymeNet Flash » Questions and Discussion » General Support » LYME may be diagnosable via transcriptome signature

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Author Topic: LYME may be diagnosable via transcriptome signature
Lymetoo
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http://www.genengnews.com/gen-news-highlights/lyme-disease-may-be-diagnosable-via-transcriptome-signature/81252365/

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--Lymetutu--
Opinions, not medical advice!

Posts: 96222 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
TNT
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This is junk science. Not good.

They are using this study to bolster their position that persistent symptoms after ABX (their touted ["effective"] 3-week course) is not due to persistent infection.

Be careful of lyme research from UC. They fully defend the denialists.

Quotes:

“Six months after completion of therapy, Lyme disease patients were found to have 31 to 60% of their pathways in common with three different immune-mediated chronic diseases. No differential gene expression signature was observed between Lyme disease patients with resolved illness to those with persistent symptoms at six months post-treatment.”

"Six months after treatment,... Despite the stark differences in how the patients reported feeling, the researchers could not detect transcriptional differences between the two groups."

"Researchers found similarities between the transcriptional changes after Lyme disease infection and other diseases... At six months, the gene signatures of Lyme disease patients showed some similarities to those from patients with immune diseases like systematic lupus erythematosus, rheumatoid arthritis, and chronic fatigue syndrome."

This study does not help our position!

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TNT
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What a total waste of grant money!!! The funds are being funneled to all the wrong places. Give the money to independent scientists, or to someone like Alan MacDonald!

[Mad]

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Jordana
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They really want to push the idea that Lyme is an autoimmune disease. What were the "gene expression signatures" of healthy controls?
Posts: 2057 | From Florida | Registered: Feb 2015  |  IP: Logged | Report this post to a Moderator
Lymetoo
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Well .. Johns Hopkins was involved here. That says it all.

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--Lymetutu--
Opinions, not medical advice!

Posts: 96222 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
   

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