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Pharmacol Res. 2016 Nov 17. pii: S1043-6618(16)30671-5. doi: 10.1016/j.phrs.2016.11.012. [Epub ahead of print]
Artemisinin and its derivatives in treating protozoan infections beyond malaria.
Ni Loo CS1, Kei Lam NS1, Yu D1, Su XZ2, Lu F3.
Abstract
Many parasitic protozoan diseases continue to rank among the world's greatest global health problems, which are also common among poor populations.
Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs.
Artemisinin (ART) and its derivatives are some of the most important classes of antimalarial agents originally derived from Artemisia annua L.
However, besides the outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess activities against other parasitic protozoa.
In this paper, we reviewed the activities of ART and its derivatives against protozoan parasites in in vitro and in vivo, including
We concluded that ART and its derivatives may be good alternatives for treating other non-malarial protozoan infections in developing countries, although more studies are necessary before they can be applied clinically.
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