1Merial Inc., 3239 Satellite Blvd, Duluth, GA 30096, USA. Electronic address: [email protected]. 2TRS Labs, Inc., PO Box 5112, Athens, GA, USA. 3Merial Inc., 3239 Satellite Blvd, Duluth, GA 30096, USA.
Abstract A randomized, blinded, negative controlled study was conducted to determine whether treatment with afoxolaner (NexGard®, Merial, Inc.) would prevent the transmission of Borrelia burgdorferi to dogs by wild caught Ixodes scapularis ticks.
Twenty healthy dogs were randomly assigned to two groups of ten dogs each.
Ten dogs were treated orally on Day 0 at a dose near the minimum recommended dose of afoxolaner of 2.5mg/kg (actual doses 2.5-3.1mg/kg) and ten control dogs were not treated.
On Day 28, each dog was infested with approximately 50 adult unfed wild caught I. scapularis that had a 67% B. burgdorferi infection rate (determined by polymerase chain reaction).
On Day 33, live ticks were counted and removed. No ticks were found on treated dogs while control dogs had an average of 21.4 ticks.
To detect infection, the B. burgdorferi-specific C6 antibody SNAP® 4Dx® test (IDEXX) was performed on serum collected before infestation (all dogs seronegative on Days -6 and 27) and on Days 48, 63, 77 and 92.
The ten treated dogs remained seronegative through the end of the study (Day 92), while nine out of the ten control dogs were infected, as demonstrated by their seroconversion to being positive for the presence of the B. burgdorferi-specific C6 antibody starting on Day 48.
In this study, all dogs treated with NexGard® 28days prior to challenge with wild caught I. scapularis ticks were protected from B. burgdorferi infection, while nine out of the ten untreated control dogs were infected.
hiker53
Frequent Contributor (5K+ posts)
Member # 6046
posted
Don't you ever wonder:
1) is this really true?
2) and if it is true and they can make a med that prevents Lyme in dogs, why can't they make one for humans? (I know the drug companies wouldn't think it profitable)
-------------------- Hiker53
"God is light. In Him there is no darkness." 1John 1:5 Posts: 8876 | From Illinois | Registered: Aug 2004
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Hiker,
I do wonder if it's true. Always. And normally I will look up where the funding came from and comment about it. Just buried under with too much reading these days.
But, you are very right to question. Good for you!
As for making this for humans... that's a thought. Maybe we will see something like that in the future?
Or maybe they'll just keep trying to make bad vaccines while running up our national debt and letting people suffer and die instead?
posted
I've seen this before, where dogs get treated. Do you happen to know whether dogs' immune systems are collectively simpler than ours?
Because I agree with Hiker - it would be awesome if they could discover something that would work for us to take internally as a prophylactic.
Posts: 13116 | From San Francisco | Registered: May 2006
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posted
Hi, I'm writing an essay on this topic, so I'm looking for any information. If you have any new research and data, please let me know. By the way, I love pets very much, so I chose the topic for the essay myself. Pets require a lot of attention and care and I feel sad when they get sick. It's very good that there are organizations that help to cure pets of serious diseases. If you love dogs and cats as much as I do, I think you will appreciate this blog https://petsoid.com/puppy-weight-calculator/ where you can find a lot of useful information about how to care for them and treat them.
[ 09-25-2020, 01:17 AM: Message edited by: Alexa Brown ]
-------------------- You become responsible, forever, for what you have tamed. Antoine de Saint-Exupery. Posts: 4 | From Dallas | Registered: Sep 2020
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Ann-Ohio
Frequent Contributor (1K+ posts)
Member # 44364
posted
Monthly dosage - costs $60 for 3 doses. Need a prescription.
-------------------- Ann-OH Posts: 1582 | From Ohio | Registered: Aug 2014
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