In vitro and in vivo antiplasmodial activity of Momordical balsamina alone or in a traditional mixture Author(s): Benoit-Vical F (Benoit-Vical, F.), Grellier P (Grellier, P.), Abdoulaye A (Abdoulaye, A.), Moussa I (Moussa, I.), Ousmane A (Ousmane, A.), Berry A (Berry, A.), Ikhiri K (Ikhiri, K.), Poupat C (Poupat, C.) Source: CHEMOTHERAPY 52 (6): 288-292 2006
Abstract: Background: Because of the dramatic situation of malaria in Africa, there is an
urgent need to find new and cheap drugs, such as herbal medicines. Here we report the
study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in
a traditional mixture used in Niger. Methods: Extracts were obtained with different
solvents and tested in vitro on Plasmodium falciparum and in vivo on Plasmodium
vinckei. Results: The best extracts are methanolic and present promising results in vivo
by intraperitoneal and oral administration. Conclusion: The antimalarial activity of M.
balsamina, traditionally used in Niger, is confirmed in vitro and in vivo without any
toxicity in healthy mice.
Addresses: Benoit-Vical F (reprint author), CHU Rangueil, Serv Parasitol, 1,Ave Poulhes,TSA50032, FR-31059 Toulouse 9, France
CHU Rangueil, Serv Parasitol, FR-31059 Toulouse 9, France CHU Rangueil, Lab Chim Coordinat, CNRS, UPR8241, F-31054 Toulouse, France Museum Natl Hist Nat, Dept Regulat Dev Divers Mol, F-75231 Paris, France CNRS, Inst Chim Subst Nat, Gif Sur Yvette, France Univ A Moumouni, Dept Chim, Fac Sci, Niamey, Niger E-mail Addresses: [email protected] Posted by catalysT (Member # 10786) on :