Thanks David ! I've been looking for an alternative treatment for Babesia as I developed severe itching from Mepron, (Poss allergy ?). Al
Posted by dharmacleaning (Member # 2114) on :
I was just about to say the cost of babesiosis treatment isn't bad - I took clindamyacin and quinine. Had doxy before and after this combo. I don't remember if I ever did zith. Sigh. Maybe.
Posted by treepatrol (Member # 4117) on :
Differential efficacy of drug combinations in the elimination of Babesia infection in humans Combination of drugs Daily dosage (mg) Weeks after treatment Babesia detected in patient by Giemsa-stained blood smears Hamster inoculation
Combination A Clindamycin plus quinine-- Daily Dosage Clindamycin 1200mg quinine 1950mg Weeks 2=positive 4=pos 8=pos 12=pos
Combination B Azithromycin plus quinine Daily Dosage Azithromycin 1000mg, Quinine 1950mg Weeks 2=Negative 4=Neg 8=Neg 12=Neg
A 10-day course of therapy with combination A was given and combination B was administered for another 10 consecutive days two months after initial treatment, and hamsters inoculated with 1 ml of the patient's blood were used to verify the clearance of babesial infection.
Looks like that cured it? Camp B wins combination B !!!!
Department of Parasitology and Tropical Medicine,National Defense Medical Center, Taipei,Taiwan, Republic of China: Department of Pediatrics, Tri-Service General Hospital, Taipei,Taiwan, Republic of China
[ 08. May 2007, 08:02 AM: Message edited by: treepatrol ]
Posted by Lymetoo (Member # 743) on :
I never took mepron either. Cleared it with clindamycin/quinine and artemisinin.
My doctor has stats on HIS patients who have been treated with clindy/Q or mepron/zith. He has about a 5% better result with clindy/Q!!
Thanks for the link, david.
Posted by treepatrol (Member # 4117) on :
up
Posted by Vermont_Lymie (Member # 9780) on :
Thanks all for the valuable information.
I just got my Quest test results back yesterday -- with a very strong positive for Babesia.
Seven months after starting tx for lyme -- it is good to know.
My llmd prescribed malarone, which I have not yet started to take. Will pick it up tonight. Also taking 7g/amoxy/day for lyme.
any of you wonderful experts know how malarone compares with these other treatments, zith & quinine?
Many thanks!
Yours, VL Posted by Lymetoo (Member # 743) on :
Malarone is known as "mepron lite."
Posted by CaliforniaLyme (Member # 7136) on :
With tissue stage Babesiosis- which WA1 is but not Microti I believe (could be wrong here- correct me if I am!*) Malarone is a better choice!!! Better tissue penetration thahn Mepron- was a paper on it years back-
Posted by jasonsmith (Member # 10914) on :
quote:Originally posted by CaliforniaLyme: With tissue stage Babesiosis- which WA1 is but not Microti I believe (could be wrong here- correct me if I am!*) Malarone is a better choice!!! Better tissue penetration thahn Mepron- was a paper on it years back-
How does that compare to the combo of Azithromycin plus quinine?
Posted by oxygenbabe (Member # 5831) on :
I can't recall-is quinine hard on the system, or was it clindamycin? If its the latter, this might be a good regimen. But how many days? Plus on giemsa smear my babesia doesn't show up but its positive on FISH. So, I don't know how I'd re-test, I guess FISH.
Posted by Boomerang (Member # 7979) on :
I don't know the answers, but hubby is on Clindamycin/quinine combo now. Sounds like his stomach is about to erupt.
Posted by bpeck (Member # 3235) on :
Excellent article... Read the last page on immunocompromised patients w/Babs.. interesting.
Barb
Posted by treepatrol (Member # 4117) on :
quote:Originally posted by treepatrol: Differential efficacy of drug combinations in the elimination of Babesia infection in humans Combination of drugs Daily dosage (mg) Weeks after treatment Babesia detected in patient by Giemsa-stained blood smears Hamster inoculation
Combination A Clindamycin plus quinine-- Daily Dosage Clindamycin 1200mg quinine 1950mg Weeks 2=positive 4=pos 8=pos 12=pos
Combination B Azithromycin plus quinine Daily Dosage Azithromycin 1000mg, Quinine 1950mg Weeks 2=Negative 4=Neg 8=Neg 12=Neg
A 10-day course of therapy with combination A was given and combination B was administered for another 10 consecutive days two months after initial treatment, and hamsters inoculated with 1 ml of the patient's blood were used to verify the clearance of babesial infection.
Looks like that cured it? Camp B wins combination B !!!!
Department of Parasitology and Tropical Medicine,National Defense Medical Center, Taipei,Taiwan, Republic of China: Department of Pediatrics, Tri-Service General Hospital, Taipei,Taiwan, Republic of China
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