LymeNet Flash: Uncoupling Mitochondrial Oxidative Phosphorylation

This is topic Uncoupling Mitochondrial Oxidative Phosphorylation in forum Medical Questions at LymeNet Flash.

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Posted by Marnie (Member # 773) on :

The latest drug to treat Parkinsons Disease is called Rottlerin.

It is a PKC delta inhibitor.

``Neuroprotective Effect of PKC{delta} Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease.''

"Rottlerin Inhibits Insulin-Stimulated Glucose Transport in 3T3-L1 Adipocytes by

Uncoupling Mitochondrial Oxidative Phosphorylation"

Does that sound familiar to some of you here? Remember DNP...ICHT to speed up glycolysis via uncoupling oxidative phosphorylation?

I wonder if the "side effects" will include sudden weight loss and/or sudden death?

Get your Mg level up...way up before attempting this!

Posted by Carol in PA (Member # 5338) on :

Marnie,
Here is another article regarding Mitochondrial Oxidative Phosphorylation.

CFS - a Symptom of Mitochondrial Failure
http://www.drmyhill.co.uk/article.cfm?id=381

This is the part that interested me. (Hah, just cut to the chase, and tell me how to fix the problem.)

Treatment package for failing mitochondria

l. PACE - do not use up energy faster than your mitos can supply it.

2. FEED THE MITOCHONDRIA - supply the raw materials necessary for the mitochondria to heal themselves and work efficiently, namely
D-ribose,
Co-enzyme Q10,
acetyl-L-carnitine,
NAD and
magnesium

3. ADDRESS THE UNDERLYING CAUSES
4. ADDRESS THE SECONDARY DAMAGE

Many of us have severe fatigue as part of our pattern of symptoms.
Those of you who take the time to look at the article will notice that much of the information applies to people with Lyme.

Carol

Posted by bejoy (Member # 11129) on :

Tell me about NAD. Can you get enough of this through taking a B complex? Is there another way to get it besides taking Niacin that makes you flush?

Posted by 5dana8 (Member # 7935) on :

Thanks for posting Marnie [Smile]

What does NAD stand for?

Posted by Marnie (Member # 773) on :

NAD.

Nicotinamide adenine dinucleotide

Coenzyme

Comes from this:

A form of vitamin B3, (niacin) called nicotinamide.

Nicotinamide is joined with Ribose and ADP to form NAD+. So...

B3 + ribose + ADP -> NAD

In cells, most oxidations are accomplished by the

removal of hydrogen atoms.

Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons.

(Acquire electrons = reduced. How's that for confusing?!)

NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH.

However, only one proton accompanies the reduction.

The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium.

For NAD, the reaction is thus:

NAD+ + 2H -> NADH + H+

NAD participates in many redox reactions in cells, including those

� in glycolysis and most of those

� in the citric acid cycle of cellular respiration.

The reducing potential stored in NADH can be converted to ATP through the aerobic electron transport chain or used for anabolic metabolism.

ATP is the universal energy currency of cells, and the contribution of NADH to the synthesis of ATP under *aerobic conditions* is substantial.

However, under certain conditions (e.g. hypoxia) the aerobic regeneration of oxidized NAD+ is unable to meet the cell's immediate demand for ATP.

In contrast, glycolysis does not require oxygen, but it does require the anaerobic regeneration of NAD+.

The oxidation of NADH to NAD+ in the absence of oxygen is called fermentation.

Mindblowing...isn't it? How did anyone ever figure this all out?

Posted by 5dana8 (Member # 7935) on :

Thanks Marnie for the detailed explanation [Smile]