* The use of expired doxycycline may lead to the Fanconi-type syndrome which is characterised by polyuria and polydipsia with nausea, vomiting, proteinuria, glucosuria, acidosis, amino-aciduria, hypophosphataemia and hypocalcaemia, hypokalaemia and hyperuricaemia.
Discard any unused Doxycycline when it expires or when it is no longer needed. Never use Doxycycline past the expiration date. Expired Doxycycline can cause a dangerous syndrome resulting in damage to the kidneys.
Expired doxycycline can cause a dangerous syndrome resulting in bruise ado the kidneys.
1: Ann Univ Mariae Curie Sklodowska [Med]. 1989;44:59-64. Links
[The influence of vibramycin on the small intestine of the rat] [Article in Polish]
Majewska T, Beń-Skowronek I. The experiments were carried out on the rats of Wistar race. One group administered vibramycin before expiration date for 10 days. Another group was given outdated vibramycin for the same period of time. The small intestine was examined histologically (hematoxylin and eosin) and histochemically (acid phosphatase, alkaline phosphatase, mucopolysaccharides, RNA). Division figures in small intestine epithelium were also counted. It was found out that the activity of acid phosphatase and RNA was increasing in animals obtaining vibramycin before expiration date. Mucopolysaccharides and alkaline phosphatase reacted weaker than in the control intestine. The intestinal mucosa showed considerable destruction. In both cases the number of division figures in the cells of small intestine epithelium decreased, particularly after administration of expired vibramycin.
PMID: 2485248
Posted by Cobweb (Member # 10053) on :
So that' what happened to the tribe on Vanuatu- and here I thought I was doing a good deed.
Posted by Greatcod (Member # 7002) on :
I believe that all the antibiotics of the tetracycline class are dangerous after the expiration date. Not true with a lot of meds, but true of this group.
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