I'm having a really bad herx today...but i'm concerned because i keep feeling that I have to go to the bathroom (pee). And i go and nothing comes out. It almost feel like I'm getting a bladder infection with out the burn. I hope its not my kidneys or anything. I just started Rafampin could that be it? Should i just call the doctor?
Posted by Fran_40 (Member # 20176) on :
Hi there, I am a newbie here, but I was reading your post, and if I were you, Yes anytime you have a problem with medications and having a side effect, you should most definately call the Dr. If it gets worse today, the only option you may have is to go to the Emergency room. I would just feel better knowing than sitting and worrying. Just my advice. Hope you feel better soon! Fran
Posted by Peedie (Member # 15355) on :
Hi butterfli
If you go to "search" on this site you will find many other people have posted about this same thing. It is Lyme related.
I personally don't think it is abx related as my daughter has had this off and on whatever abx or no abx at all.
You can purchase a kit at the drug store, I know Rite Aid has them, which if dipped in your urine will tell you if you have an infection going on.
Some people as they get older can get a serious infection without the burn.
Antibiotics give us yeast issues, so a UI is always something to consider. Diet will help control yeast issues. But I know for my daughter it happens even without UI.
We have a couple doctors looking for answers. I hope someone will come along with a suggestion.
-p
Posted by butterfli (Member # 17186) on :
Yea I'm thinking that I should just go to ER maybe. I dont know what to do.
Posted by Keebler (Member # 12673) on :
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Just feeling like you have to pee is a frequent symptom of lyme patients. However, if nothing has been able to come out for many hours, you might need some help.
It might not require an ER visit but just a call to your GP - there is a medicine that s/he can call into the pharmacy if it is severe. However, there are other steps that might help, too.
Nothing comes out at all?
How long have you gone without emptying your bladder? What is your level of magnesium supplement? Magnesium might help as it can help tight muscle spasms release.
Does running warm water over your hands help? A heating pad on your lower abdomen, too, may help.
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Posted by liesandmorelies (Member # 15323) on :
Go to the doctor and or ER. Better to veer on the side of caution then to allow your organs to possibly get damaged. It is not "normal" for nothing to come out.
Good luck and you are in my prayers.
Posted by MorningSong (Member # 19989) on :
I agree with others. I would go to the ER or call your doctor. Better to be safe. Sometimes UTI infections can spread to the kidneys and cause this symptom. If I had this problem, this is what I would do.
Posted by Lymetoo (Member # 743) on :
Are you able to pee at all?? IF not, you may need to go to the ER. If you can pee, then MAYBE you just need to push fluids until you can get hold of your doctor.
Personally, I wouldn't take any more Rifampin until I would be able to speak to my dr.
Posted by Starfall1969 (Member # 17353) on :
I agree with tohers here.
At least put in a call to your GP/LLMD, tell them what's going on and ask if they'd advise going to the ER.
If you can get hold of the dr. who prescribed the Rifampin, ask if you should discontine the med for the time being.
Always better to err on the side of caution.
Posted by Lymetoo (Member # 743) on :
Where's butterfli?
Posted by Looking (Member # 13600) on :
Yes Rifampin can cause swelling of the kidneys and even kidney failure. Please get medical help.
Here's a case of kidney problems due to Rifampin:
A 64-year-old male was treated continuously with rifampin, isoniazid and streptomycin for pulmonary atypical mycobacteriosis, Mycobacterium kansasii. Five weeks after beginning the treatment, the patient suddenly developed acute renal failure. A renal biopsy showed crescentic lesions characteristic of rapidly progressive glomerulonephritis with moderate interstitial changes.
Serum antirifampin antibody was detected, and the cessation of rifampin treatment was followed by a rapid spontaneous recovery of the patient's renal function. This is, to our knowledge, the first case of rapidly progressive crescentic glomerulonephritis associated with rifampin treatment where circulating antirifampin antibody is demonstrated and the renal function spontaneously improved after discontinuing rifampin treatment.
Nephrology Department, Piti�-Salp�tri�re Hospital, Paris, France
Sir,
Rifampicin is one of the major antituberculous drugs used for a disease increasing world-wide. This antibiotic is also a common treatment for severe staphylococcal infections [1]. Numerous side-effects have been reported in rifampicin-treated patients.
Acute renal failure (ARF) is a less-known toxicity that usually occurs in patients receiving intermittent or interrupted therapy [1,2]. Only few cases of ARF following a first daily continuous course have been reported and most of them were secondary to acute tubular necrosis [1,3]. We present a case of acute interstitial nephritis due to a continuous rifampicin treatment.
Case.
A 61-year-old alcoholic male weighing 40 kg was treated for the first time for pulmonary tuberculosis by rifampicin 300 mg, isoniazid 150 mg, pyrazinamide 1000 mg, and ethambutol 600 mg daily. After 2 months pyrazinamide and ethambutol therapy were stopped. Ten weeks after starting the antituberculous therapy and while the patient was still receiving daily rifampicin and isoniazid, a non-oliguric rapidly progressive renal failure occurred.
The laboratory data were haemoglobin 10 g/dl, leukocyte count 6700/mm3, platelet count 160 000/mm3, Na 138 mmol/l, K 3.9 mmol/l, Ca 2.54 mmol/l, glucose 5.2 mmol/l, blood urea nitrogen 20 mmol/l, and serum creatinine 472 �mol/l. Liver function tests were normal.
Urine analysis showed proteinuria 1.5 g/24 h, absence of white blood cells, red blood cells, and light chains. Clinically there was no rash, arthropathy, lumbar pain, diarrhoea, or vomiting. Light microscopy of the renal biopsy showed features of an acute interstitial nephritis. There was no immunoglobulin deposits in the immunofluorescence fragment. Rifampicin-dependent antibodies were negative. Rifampicin was stopped and replaced by sparfloxacin. Renal function returned to normal level within 3 weeks after withdrawal of the rifampicin. The patient did not require dialysis and was discharged from the hospital 3 weeks later.
Comments.
Rifampicin treatment regimens are of three types: `continuous', with a daily dose; `intermittent', with ingestion of a dose one, two, three, or five times weekly; and `interrupted', when therapy is resumed after a course of daily or intermittent treatment and a subsequent drug-free interval [1]. ARF due to acute tubular necrosis usually occurs in patients who receive intermittent or interrupted regimens [1,2]. These subjects may also present with intravascular haemolysis or thrombocytopenia with a fulminant systemic reaction [4]. Rifampicin-dependent antibodies are usually detected and even a single dose after a medication-free period may cause a severe reaction and may induce sensitization [4,5].
Fourteen cases (including our patient) of rifampicin-induced ARF have been reported after a daily continuous treatment [1,3]. Kidney biopsy revealed a rifampicin-induced interstitial nephritis in six of these 14 cases (43%). Four of these six patients (66%) required haemodialysis treatment. The recovery was complete in all six patients [1]. None of these patients received corticosteroids. Tests for rifampicin dependent antibodies were uniformly negative [4,5].
We suggest that continuous, non-interrupted mode of administration of rifampicin can be responsible for ARF due to an acute interstitial nephritis.
References
De Vriese An S, Robbrecht DL, Vanholder RC, Vogelaers DP, Lameire NH. Rifampicin-associated acute renal failure: pathophysiology, immunologic and clinical features. Am J Kidney Dis1998; 31: 108-115[ISI][Medline] Covic A, Goldsmith DA, Segall L et al. Rifampicin-induced acute renal failure: a series of 60 patients. Nephrol Dial Transplant1998; 13: 924-929[Abstract/Free Full Text] Power DA, Russell G, Smith W et al. Acute renal failure due to continuous rifampicin. Clin Nephrol1983; 20: 155-159[Medline] Diamond JR, Tahan SR. Ig G-mediated intravascular hemolysis and nonoliguric acute renal failure complicating discontinuous rifampicin administration. Nephron1984; 38: 62-64[Medline] Mauri JM, Fort J, Bartolome J et al. Antirifampicin antibodies in acute rifampicin-associated renal failure. Nephron1982; 31: 177-179.[Medline]
Posted by Geneal (Member # 10375) on :
Rifampin gave me bladder spasms. They were very uncomfortable.
The sudden cramping of my bladder as if it were full...
Nothing there to get out.
It is a side effect of rifampin. I had this as well as
Multiple muscle cramping, especially in my legs and especially at night.
Extra magnesium helped some.
This was one of my least favorite meds.
Call the LLMD just to be sure.
Drink lots of water.
Hugs,
Geneal
Posted by butterfli (Member # 17186) on :
Hi all thanks for your replies. unfortunately I have been unable to get out of bed today due to this aweful herx i'm having. I will call the doctor first thing in the morning I'm very concerned. I have been going a little bit but i still have alot of pressure. Thanks for all your replies.