I thought it would need to be higher in order to cross the BBB?
Interested in others' doses of Doxy (IV or PO) just for comparison. Thanks!
Posted by Sammi (Member # 110) on :
When I did IV Doxy, it was 400 mg daily. Are you on any other meds?
Posted by Lymetoo (Member # 743) on :
Is it the same for IV as for orals??
If so, the optimum dosage is 400mg per day.
Posted by Hopeful2010 (Member # 22958) on :
Dr. B's guidelines say 400 mg a day for it to be effective. The usual dose is 200 mg a day. My doc told me 200 mg a day. I am taking 300 mg a day. and may increase to 400 mg soon.
Posted by pas (Member # 22416) on :
Thank you all so much for the quick replies!! I really appreciate it.
I was confused because of what Dr. B says (400mgs for IV).
I'm not sure how PO doses compare to IV, but I think Doxy is usually very effective orally, which would make me think its absorption rate is pretty high...
In which case there shouldn't be much difference when it comes to dosing PO vs. IV.
I am tiny, though, so maybe I'll be able to get by on less than 400mgs. Just don't want to waste any time at this point...would rather wipe out as many bugs as possible!
Preaching to the choir, I know...
Thanks again!
Posted by pas (Member # 22416) on :
So...one more question for those that have used 400mgs of Doxy.
Was your dose split am/pm, or did you get it all at once?
Thanks.
Posted by Sammi (Member # 110) on :
I infused 400 mg at one time, and it was a long infusion.
Do you have a port-cath or a PICC line? From what I understand, IV Doxy can be caustic to the veins and it is better to infuse through a port.
Posted by Haley (Member # 22008) on :
I am doing 150 mg 2 X a day 12 hours apart. I have a port. I may increase to 200 2 X a day.
Posted by pas (Member # 22416) on :
Thanks for this info, Sammi.
I have a PICC. This is day 5 of the Doxy and I feel HORRIBLE!!! Hoping it's a herx.
The last time I tried Doxy I didn't herx even though I'd been on it for over a month. But then again, it was oral, I wasn't taking as much, and probably wasn't absorbing it anyway b/c of GI issues (hence the PICC).
I had read that Doxy is caustic but so far haven't had any pain...I'm assuming I'd have pain if there was a problem? Hope I'm not being naive about it...
Isn't the PICC a type of central line?
Posted by canefan17 (Member # 22149) on :
Some even do as much as 600mg orally
200 seems like nada
Posted by pas (Member # 22416) on :
Heehee, thanks OTM. Point taken!
I am one of "those" patients. Seriously wouldn't be alive today if I hadn't advocated for myself.
I've actually read that oral Doxy has a pretty high absorption rate in most people...so there shouldn't need to be a dosing difference between oral vs. IV like some other meds.
(although I have atrophic gastritis and malabsorption, so for me IV is likely more effective regardless of the dose...)
My doc is willing to go up to 400mgs, just wants to try this first. You're right, since I'm herxing, maybe this is enough for now. I'm also a tiny shrimp, so normal adult doses of anything don't usually apply to me!
The plan is to start with Doxy, add IV Zithro, and then a cyst buster down the road...assuming my insurance can be convinced it's all necessary, that is!!
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Seriously wouldn't be alive today if I hadn't advocated for myself.