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Posted by John S (Member # 19756) on :
 
I got this under Minocycline in Wikipedia. Why doesn't someone ask if the reason it works maybe that Minocycline is a deep penetrating antiobiotic and that the diseases maybe be caused by a bacteria?

Anti-inflammatory and neuroprotective
Current research is examining the possible neuroprotective and anti-inflammatory effects of minocycline against progression of a group of neurodegenerative disorders including multiple sclerosis (MS), rheumatoid arthritis (RA), amyotrophic lateral sclerosis (ALS), Huntington's disease, and Parkinsons disease.[13][14][15][16]

In the Journal of the American Medical Association (JAMA), Chris Zink, Janice Clements, and colleagues from Johns Hopkins University reported that minocycline may exhibit neuroprotective action against AIDS Dementia Complex by inhibiting macrophage inflammation and HIV replication in the brain and cerebrospinal fluid.[17] Minocycline may suppress viral replication by reducing T cell activation.[18] The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase,[19] an inflammatory enzyme associated with brain aging, and the antibiotic is being studied for use in Alzheimer's disease patients.[20] Minocycline may also exert neuroprotective effects independent of its anti-inflammatory properties.[21] Minocycline also has been used as a "last ditch" treatment for toxoplasmosis in AIDS patients. Minocycline is neuroprotective in mouse models of amyotrophic lateral sclerosis (ALS) and Huntington's disease and has been recently shown to stabilize the course of Huntington's disease in humans over a 2-year period.

As an anti-inflammatory, minocycline inhibits apoptosis (cell death) via attenuation of TNF-alpha, downregulating pro-inflammatory cytokine output. This effect is mediated by a direct action of minocycline on the activated T cells and on microglia, which results in the decreased ability of T cells to contact microglia which impairs cytokine production in T cell-microglia signal transduction .[22] Minocycline also inhibits microglial activation, through blockade of NF-kappa B nuclear translocation.

A recent study reported the impact of the antibiotic minocycline on clinical and magnetic resonance imaging (MRI) outcomes and serum immune molecules in MS patients over 24 months of open-label minocycline treatment. Despite a moderately high pretreatment relapse rate in patients in the study prior to treatment, no relapses occurred between months 6 and 24. The only patient with gadolinium-enhancing lesions on MRI at 12 and 24 months was on half-dose minocycline. Levels of interleukin-12 (IL-12), which at high levels might antagonize the proinflammatory IL-12 receptor, were elevated over 18 months of treatment, as were levels of soluble vascular cell adhesion molecule-1 (VCAM-1). The activity of matrix metalloproteinase-9 was decreased by treatment. Clinical and MRI outcomes in this study were supported by systemic immunological changes and call for further investigation of minocycline in MS.[23][24][21][25]

A recent study (2007) found that patients taking 200 mg of minocycline for 5 days within 24 hours of an ischemic stroke showed an improvement in functional state and stroke severity over a period of 3 months compared with patients receiving placebo
 
Posted by sutherngrl (Member # 16270) on :
 
Not sure why they don't mention bacterial as a possibility.

Not everything is bacterial though. MS and all other illnesses of unknown cause, can be from bacterial infections, viral infections and who knows what else.

I think it is encouraging that Minocycline can work against things other than bacterial, since many of us use it and may have more going on than just bacterial.
 
Posted by Keebler (Member # 12673) on :
 
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Remember to always use liver protection with mino. It can be toxic to the ears and balance system. Some things can help prevent that, though. Ginger, B-6, Magnesium, Milk Thistle. More here:

3/4 of the way down page one, there are lots of LIVER LINKS:

http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=065801

Topic: TINNITUS: Ringing Between The Ears; Vestibular, Balance, Hearing with compiled links - including HYPERACUSIS
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