LymeNet Flash: Why tetracyclines are the first choice

This is topic Why tetracyclines are the first choice in forum Medical Questions at LymeNet Flash.

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Posted by Marnie (Member # 773) on :

"Masood Syed 2001

Designing a scheme for the purification of a

***phospholipase PLA2 produced by

the Lyme disease pathogen,*** Borrelia burgdorferi

Cluss"

http://www.middlebury.edu/media/view/254794/original/CHEM_THESIS_TITLES.xls

Bb produces PLA2... and likely secretes it = sPLA2.

...antimicrobial tetracyclines inhibit the activity of proinflammatory secretory group II phospholipase A2 (sPLA2).

PMID: 9733464

sPLA2 is NOT GOOD.

Lidocaine injected under a tick before removal (as suggested by a Canadian doc years ago) maybe also helpful.

PLA2 is way up in many diseases...autism is one.

There are many forms of PLA2.

It -> arachidonic acid (omega 6) and ouch.

Major imbalance.

Arachidonic acid metabolized to PGE2 which inhibits phagocytosis...

http://www.jbc.org/content/274/17/11660.full.pdf

http://www.experts.scival.com/umichigan/grantDetail.asp?id=3034022&n=Aronoff%2C+David&u_id=691

EPA blocks AA -> PGE2.

Omegabrite may help a LOT.

Posted by James1979 (Member # 31926) on :

Marnie, can you please explain why Omegabrite is a better supplement than "average" fish oil supplements? Is it the ratio of Omegas? If other products had a similar ratio, would you consider them as good as the Omegabrite?

Thanks!