This is topic Anyone test positive for only heterozygous A1298c in forum Medical Questions at LymeNet Flash.

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Posted by BuffyFan (Member # 34679) on :
mthfr? if so, did your doc recommend any treatments?
Posted by ralphi (Member # 33834) on :
Me. No treatment yet; we're testing homocystine levels first. From my research so far, I believe hetero 1298 is the least damaging mutation and affects toxin elimination more than anything.

Not so much clotting issues like the other gene. My doc said I can stay on birth conrol pill for now.
Posted by aperture (Member # 34822) on :
Me too. I am heterozygous A1298C, have normal homocysteine levels, but high B12 and folate. Just waiting for my followup appt to find out what the Dr is gonna do about it.
Posted by BuffyFan (Member # 34679) on :
I have normal homocysteine levels too, and normal folate but low serum b12

not sure if I should do anything
Posted by dal123 (Member # 6313) on :
Don't rely on the homocysteiene for treatment, there is another precursor that many dr's don't test for , but unwed to supplement with Methyl B12 and Methylfolinic acid & Glutathione!!

busy methylating, I hope ! [Smile] )
Posted by TerryK (Member # 8552) on :
Dr. Yasko has written if you have a methylation issue it's like having diabetes and not treating.

Anyone with lyme or other infections needs all the detox help they can get. I do believe it makes sense to treat if you know you have a weakness, especially if you have a chronic illness that puts an extra toxic burden on your body.

The 2 MTHFR tests are just a small part of the methylation cycle. You could have a CBS upregulation or some other mutation that exacerbates the one that you know you have. Best to treat at least what you know for sure is a problem.

I have the same one you have plus others. Here are some of my notes on MTHFR A1298C

Does not impact levels of homocysteine but can cause low levels of BH4. Has been mapped to the SAMe regulatory region of the gene.

Causes an inability to convert BH2 to BH4 and can cause exceedingly low BH4. Low BH4 means more severe parasitic infections, difficulty deactivating viruses, diabetes, hypertension and arteriosclerosis. Serotonin synthesis as well as ammonia detoxification require BH4. Low BH4 will affect dopamine levels. Excess ammonia in the gut may alter gut PH and cause microbial imbalances.

For anethesia - the availability of BH4 helps to determine whether nitric oxide, peroxy nitrite or super oxide are formed as a function of the urea cycle; two molecules of BH4 are required for the formation of nitric oxide, one molecule of BH4 leads to the formation of peroxy nitrite and the absence of BH4 leads to super oxide formation.

Keeping ammonia under control is of paramount importance for people with this mutation as any extra ammonia generated drains stores of BH4 which are probably already low. This will impact serotonin levels and cause fluxes in dopamine (mood swings). Restoring levels of BH4 will help serotonin synthesis maintaining dopamine in a more stable manner and helping with ammonia detoxification.

A number of the mutations in the methylation cycle can cause depleted BH4 not just this one.

I'm not a doctor
Posted by Razzle (Member # 30398) on :
Yes, I too have the hetero mutation for A1298C. I just got some methyl-folate to try. But will have to go very slowly because of the CBS homozygous mutation I have...


Yes, you should at the very least be supplementing Vitamin B12. Low serum Vitamin B12 is linked to a lot of neurological issues, some of which can become permanent if the B12 level stays low chronically.


Thanks for your obviously well-researched information - it is much appreciated.

I take yucca root powder every morning to help with the ammonia, and the difference is amazing even with only 1/8 teaspoon of the yucca root! Of course, I'm also on a low protein diet to help with the ammonia...
Posted by sk8ter (Member # 8671) on :
razzle what test did you take to check your CBS?? Did you have the Dr. Yasko test?
Posted by sk8ter (Member # 8671) on :
Please go to doctor has the most information on these mutations and the correct treatment for them since he has two mutations along with his family.
Posted by BuffyFan (Member # 34679) on :
thank you everyone!please post if you find out anything else. I had a a hard time researching, and mostly came up with women who have had lots of miscarriages and hoping to get pregnant again.

Razzle, I will take B12, thanks! You said you take yucca root powder what exactly is the difference you are feeling? oh and did you get your ammonia levels tested(or did you just know it was high because of the mutation?)

sk8ter, I have gone to that site, but I thought I read he didn't recommend treatment for this particular mutation?? or maybe I read it wrong??

I really find this all very interesting..I have suffered with insomnia since I was a kid and now all of a sudden I am having high blood pressure.
Posted by BuffyFan (Member # 34679) on :
Terry, thanks for your post, you made it a lot easier to understand. [Smile]
Posted by sk8ter (Member # 8671) on :
i do think he does for all mutations...
Posted by Razzle (Member # 30398) on :

Yes, I had the Yasko methylation test panel.


I did not have ammonia tested. But my sweat smelled like cat pee and that has now disappeared since I started taking the yucca.

I was on a low protein diet before I started the yucca, but still had the cat-pee smelling sweat. After starting the yucca, I no longer smell the strong eye-watering ammonia smell.

That's really the only concrete difference I notice, but it may also be affecting me in other ways (more subtle) that I'm just not aware of as of yet.

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