This is topic Andrographis paniculata - LINKS set in forum Medical Questions at LymeNet Flash.

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Posted by Keebler (Member # 12673) on :

Mostly to organize some links so as to provide just one link to this thread when this comes up for a post.

I hope others will feel free to add new sources to this, of course, with the intention that it's more of a collection for those wanting to learn more.

Others' experiences are helpful, too, whether good or bad as all detail helps in our education.

To note up front: not everyone does well with this. Some have gotten a rash or experienced an increase in seizure activity.

IME, this has been the only herbal supplement to help decrease both frequency and intensity of seizures.


6-30-13 Editing in this update:

for months, often, andrographis has been unavailable. During the breaks from andrographis, I've since found that BERBERINE has some of the same good effects for me, including the strengthening of a seizure threshold regarding starles. More detai:;f=1;t=121034;p=0




For some, a rash may develop. I've not had that occur.

So, this is a fabulous herb for some; and not for others. As before taking anything new, read all you can from many academic sources.

Best to consult with your LLMD or LL ND (naturopathic doctor) first.

And always start with a very low dose and then hold that for a while before increasing.

As I don't take any pharmaceuticals, I've not had to be concerned with any Rx interaction. However, most here are on pharmaceuticals for lyme and

also Rx for other things as well.

I'm not comfortable (and certainly have no medical background or training) so would not even guess on taking this with certain Rx. Be sure to ask your LL doctor first as there could be interactions.

Some of those may be addressed through articles below or with a web search but a good LL doctor should know before you take anything new, anyway. They need to know and offer their advice.

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Search LymeNet Archives for past threads.

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Recommended by master herbalist, Stephen Buhner in his book "Healing Lyme" (but lately he prefers to not use it, perhaps because of a few adverse reports. But I did great even at top dose of 16 tablets a day, Planetary Formulary)


Read the full chapter on ANDROGRAPHIS and also see his website for updated thoughts. His link set will be in the next post.

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Also recommended in "The Lyme Disease Solution"

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This links keeps changing. You might print out the entire article for safe keeping - or copy to a computer file.


In-Depth Review

This is the most comprehensive article on the web. This article has disappeared from time to time and I�m glad to see it back again � if you can connect to it � go ahead and copy & paste � and print to preserve this page.

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Essen Herb - Essential Health Care

Andrographis paniculata � article

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Science Rediscovers the Forgotten Herb Andrographis

02/13/2012 � Huffington Post

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NaturalPedia � entries for Andrographis

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PubMed Search of medical literature

Andrographis � 423 abstracts

andrographis, cancer � 54 abstracts

andrographis, melanoma � 3 abstracts

andrographis, liver � 46 abstracts

andrographis, kidneys � 12 abstracts

andrographis, pain � 7 abstracts

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Planetary Herbals Full Spectrum Andrographis - Extract with whole herb - TABLETS

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Herb Pharm - Andrographis TINCTURE

[ 06-18-2016, 07:11 PM: Message edited by: Keebler ]
Posted by Keebler (Member # 12673) on :
Buhner's Links Set

Andrographis has a chapter in Buhner's "Healing Lyme" book. However, since publication he's not as keen on it as the first line. So, check his website as to what he says about it -- and remember that individual responses may vary.

This works great for me but I know it can be the opposite for others. See what he first wrote as that detail is still accurate - it's just that any protocol goes through shifts for various reasons.

Book: Healing Lyme: Natural Healing And Prevention of Lyme Borreliosis And Its Coinfections - by Stephen Harrod Buhner




Buhners recommendations for professionals familiar with his work. Scroll down for list.

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Not about lyme, though, BUHNER's NEW BOOK IS READY NOW !

Thanks to RiverSpirit for alerting us to the arrival of this brand new edition:

(Going through the Amazon link to the left so that some of the proceeds go to LymeNet): ernatives+for+Treating+Drug-resistant+Bacteria

Herbal Antibiotics, 2nd Edition: Natural Alternatives for Treating Drug-resistant Bacteria

Paperback - 480 pages - You can look inside the book at the link - $15.

Kindle version also available.

- by Stephen Harrod Buhner

Qualifies for Free shipping at Amazon (with $25. purchase)

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Other links of that author:

Buhners other books (included the 1st Edition of his new book) at Amazon

[ 10-31-2012, 04:07 PM: Message edited by: Keebler ]
Posted by Keebler (Member # 12673) on :
When considering herbal / nutritional / adjunct methods:

if at all possible - because each person & each case is different - it's best to consult with an ILADS-educated LL ND (lyme literate naturopathic doctor) (or similar) who has completed four years of post-graduate medical education in the field of herbal and nutritional medicine -

- and someone who is current with ILADS' research & presentations, past and present, and has completed the ILADS Physician Training Program (see: )

Many LL NDs incorporate antibiotics (depending upon the licensing laws in their state). Some LLMDs and LL NDs have good working relationships.

When possible, it's great to have both a LLMD and LL ND and even better when they have a long-standing professional relationship.


How to find an ILADS-educated LL:

N.D. (Naturopathic Doctor);

L.Ac. (Acupuncturist);

D.Ay. (Doctor of Ayurvedic Medicine);

D.O.M. (Doctor of Oriental Medicine);

D.O. (Doctor of Osteopathy);

D.C. (Doctor of Chiropractic);

Integrative / Holistic M.D., etc.

(Be aware that those in some categories can have zero or various levels of formal herbal &/or nutritional education, perhaps even just a short course. Do ask first.)

Links to many articles and books by holistic-minded LL doctors of various degrees who all have this basic approach in common:

Understanding of the importance of addressing the infection(s) fully head-on with specific measures from all corners of medicine;

knowing which supplements have direct impact, which are only support and which are both.

You can compare and contrast many approaches.


BODY WORK links with safety tailored to lyme patients,


BIOPHOTON - BIONIC 880 (& PE-1) links, and

RIFE links.;f=2;t=013239;p=0

What ILADS is

& WHY you need an ILADS-educated, Lyme Literate Doctor (whether LLMD or LL ND, or both)
Posted by SusanH (Member # 40582) on :
This is the correct link on the naturalpedia if anyone has tried and got an error message:

Thank you for all this help, Keebler,

Posted by Keebler (Member # 12673) on :

Thanks for that updated link. So often, links change and I can't even try to keep up. I corrected that in the set above, thanks to your detective work.

Also glad to hear that this detail is of some help, in some way. Thanks for that note, too.
Posted by SusanH (Member # 40582) on :
[hi] Keebler.

While I have been more of a silent lurker these past 4 months, learning all I can from everyone, you have no idea how grateful I am for the research and info you provide.

I've been soaking it all up.

Thanks again - SusanH
Posted by lookup (Member # 44574) on :
Thanks Keebler!
Posted by Keebler (Member # 12673) on :
Susan & lookup,

Wow, thanks for the kind notes.

Just remember that andrographis does not work the same for everyone -- and that first week or two can be a real sleep enhancer around the clock.

Berberine seems better for me by day & andrographis by night.

[ 02-15-2016, 06:51 PM: Message edited by: Keebler ]
Posted by Keebler (Member # 12673) on :

J Neuroinflammation. 2016 Feb 9;13(1):34. doi: 10.1186/s12974-016-0498-6.

Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes.


These results suggest that andrographolide may be useful as a therapeutic for neuroinflammatory diseases, especially those characterized by chemokine dysregulation.

PubMed Search: Andrographis - 642 abstracts
Posted by Keebler (Member # 12673) on :

Mol Med Rep. 2016 Oct;14(4):3573-80. doi: 10.3892/mmr.2016.5717. Epub 2016 Sep 6.

Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro.

Abstract - Excerpts:

Nerve regeneration remains a challenge to the treatment of peripheral nerve injury. . . .

. . . Andro has been reported to facilitate the reduction of edema and to exert analgesic effects in the treatment of various diseases.

These findings suggest that Andro may be considered a promising anti‑inflammatory agent that may suppress destruction and accelerate proliferation of Schwann cells following peripheral nerve injury. . . .

. . . the present study may provide valuable evidence for the further exploration of the effects of Andro on peripheral nerves. . . .


SCHWANN CELLS (TA: Gliocytus periphericus) (named after physiologist Theodor Schwann) or neurolemmocytes are the principal glia of the peripheral nervous system (PNS).

Glial cells function to support neurons and in the PNS, also include satellite cells, olfactory ensheathing cells, enteric glia and glia that reside at sensory nerve endings, such as the Pacinian corpuscle.

There are two types of Schwann cell,

myelinating and


Myelinating Schwann cells wrap around axons of motor and sensory neurons to form the myelin sheath.

The Schwann cell promoter is present in the Downstream region of the Human Dystrophin Gene that gives shortened transcript that are again synthesized in a tissue specific manner.

During the development of the peripheral nervous system, the regulatory mechanisms of myelination are controlled via feedforward interaction of specific genes, influencing transcriptional cascades and shaping the morphology of the myelinated nerve fibers.[1]

Schwann cells are involved in many important aspects of peripheral nerve biology

— the conduction of nervous impulses along axons, nerve development and regeneration,

trophic support for neurons,
production of the nerve extracellular matrix,

modulation of neuromuscular synaptic activity, and presentation of antigens to T-lymphocytes. . . .
Posted by Keebler (Member # 12673) on :

8 Proven Health Benefits of Andrographis

By Marc Seward - Jan. 2,2019

PubMed Search of Medical Literature

Andrographis - 915 abstracts

Be sure to see the most recent articles on this by master herbalist Stephen H. Buhner, too. Where ever you see a good article, be sure to look up that author's name to see their most recent thoughts on the topic as well.

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