This is topic Western Blot Test: Lab Corp in forum Medical Questions at LymeNet Flash.

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Posted by PhilH (Member # 41952) on :
I have been experiencing Lyme symptoms for over a year now. Started out with frequent urination and digestive issues with heart palpitations. Went away for a while. Came back.

Abdominal pains, GI issues and over the last three months I have developed neuro issues including numbness and tingling in my arms, hands, feet, legs and head. Light sensitivity, stiff neck and muscles all over my body. Fatigue etc...

I have had CT and MRI's and extensive blood work. All normal. Neurologist ruled out MS via clinical exam and normal brain MRI.

I had a Lyme screening test performed by Quest which was negative and they refused to do a WB with a negative screening.

Then I paid out of pocket for a Lab Corp WB test which showed:

Negative for IgG 93, 66, 58, 45, 41, 39, 30, 28, 23, and 18.

Negative for IgM 41 and 39.

Present/Abnormal IgM 23.

So the only thing that showed up in the WB was the IgM P23 which they listed as present/abnormal.

Any idea what this means? Should I just take this to a LLMD or should I get an Igenex test done first? Or is it not Lyme and I should be looking down a different path with an infectous disease person?

Any advice would be appreciated [Smile]
Posted by Robin123 (Member # 9197) on :
Some Lyme folks think that even one positive band showing up means Lyme. The 23 band is a positive band.

Sometimes people don't test positive until they've had some treatment and their immune system is stronger. Reasons for not testing positive at

Another possibility is that testing through a better lab, IGeneX, might show more bands., 1-800-832-3200.

Your symptoms sound like Lyme symptoms to me. It's also very common for tests to show normal for us, since they're not looking for a bacterial infection!

Up to you if you want to go ahead and get an IGeneX test. A Lyme-literate doc is going to treat you for Lyme whether you have a positive test or not, since history and symptoms matter.

Btw, I fixed my light sensitivity issues by drinking mangosteen juice, an anti-inflammatory juice you can find in healthfood stores and online. We're all different when it comes to what works for us.
Posted by Lymetoo (Member # 743) on :
Band 23 is "Lyme specific".. nothing else can cause it to show up .. except... Lyme.

I would get an appointment with an LLMD and take it from there. You could wait until the appointment to get the Igenex test, or get it now. I think you owe it to yourself!
Posted by Sammi (Member # 110) on :
I agree with the other posters. Band 23 is specific for Lyme. IgeneX includes two more Lyme-specific bands that Quest and LabCorp do not--bands 31 and 34.

You need to see a Lyme doctor and be evaluated for the co-infections ticks can transmit.

If you need doctor recommendations, you can post in the "Seeking A Doctor" section.

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