This is topic I didn't know...did you? in forum Medical Questions at LymeNet Flash.


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Posted by Marnie (Member # 773) on :
 
B. burgdorferi attach to HeLa cells and

acquire cholesterol from the epithelial cell membranes.

http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003109 2013

(HeLa cells are immortal cancer cells which are already DNA damaged and infected due to a virus - HPV - touching the cell's DNA.)

"This is in contrast to the binding to HeLa cells, where B. burgdorferi bound very well, but

***only 10 to 15% of spirochetes that bound to HeLa cells were able to achieve an intracellular location.***

This represented 2 to 5% of the total number of spirochetes added to the cultures.

This suggests that B. burgdorferi may bind to distinct receptors on different cell types, only some of which are involved in internalization, or that HeLa cells do not have the cytoskeletal structures required for the spirochete to invade.

Other invasive bacteria can invade HeLa cells, indicating that this cell type can serve as a host for intracellular localization by some bacteria.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC257809/

ONLY 10-15% achieve intracellular location.

IMO...10-15% too many.
 
Posted by GretaM (Member # 40917) on :
 
Yikes!
[Eek!]
 
Posted by Marnie (Member # 773) on :
 
Bb looks to attach to several cell types and *exchanges* amino acids and glucose for both to survive.
 
Posted by GretaM (Member # 40917) on :
 
I was going to say, "Hmmm I remember reading this somewhere before."

And then saw my name there and realized it was me.
[bonk]
 
Posted by poppy (Member # 5355) on :
 
At least you remembered it. Coming across a post of mine from several months back, I don't remember it. Memory like a sieve now.
 
Posted by Marnie (Member # 773) on :
 
B6 - active form is PLP, B3 (use niacinamide before bedtime, it is "no flush" - may have interesting dreams) and folic acid (B9)and *B12* might help. Zinc and choline play a part too...in the "methylation" cycle to drive down homocysteine.

Sublingual B complex exists, but IMO, PLP for B6 is the preferred form of that.

Re: niacin (no flush niacinamide):

http://www.sciencedaily.com/releases/2013/09/130930101836.htm

I'd like to trick my body into thinking it is exercising...

;-)
 
Posted by girl (Member # 18022) on :
 
Isn't it important to use folate instead of folic acid for methylation purposes? Check this out.



http://www.tbyil.com/B6_Methionine_Folate_Lung_Cancer.htm
 


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