[ 04-26-2014, 01:09 PM: Message edited by: Marnie ]
Posted by Razzle (Member # 30398) on :
Ah...thanks for the warning about PQQ stimulating bacterial growth...that would not be good when one has chronic Lyme/coinfections!!!
So it is my understanding that the methylation cycle sits in the inter-membrane space of the mitochondria...
If one has methylation genomic variants, then that would mean that any time the mitochondria in a cell divide, those genomic variants are replicated into the newly divided mitochondria as well, correct?
Ok, so what would the impact of more mitochondria with effectively more faulty methylation cycles floating around be - would that multiply the negative symptoms caused by the methylation genomic variants?
Would this then mean that exercise could potentially make the effects of methylation genomic variants in the exercised muscle cells more noticeable/pronounced?
Thanks for your insights...
Posted by Marnie (Member # 773) on :
I added more to my original post as you were typing.
Berberine AND CoQ10 (300mg daily)?
Interesting question about mitochondria replication.
Since the cells' normal RNA in the cytosol is different from the mitochondria RNA,
I would suspect genetic differences we normally see are not
mitochondria RNA differences,
but may be instead RNA/DNA (chromosomal) differences?
If Bb is camped out in the cytosol of the cells and the free radicals are damaging the cytosol RNA/DNA (so the cell is at a disadvantage)...and at the same time Bb is depriving the mitochondria RNA "nutrients" which are similar...
Keep in mind, Berberine is an antibacterial.
I think the mitochondria are being deprived of glucose too...in addition to the amino acids.
Are the mitochondria "sacrificing" their amino acids to keep the glucose levels up in the infected cells? Are they doing this?
"Amino acids are grouped into two classes, based on whether or not their carbon skeletons can be converted to glucose"
What about this?
"DNA methylation status at satellite repeats
in ***individual cell nuclei***
AND
***chromosomes***."
So...the methylation - genomic variants...are most likely the result of different pattern sequences (groups of 3) on our chromosomes.
Genetic variation will result in phenotypic variation
if variation in the
order of nucleotides
in the DNA sequence
results in a difference in the order of amino acids in proteins coded by that DNA sequence,
and if the resultant differences in
amino acid sequence
influence the shape, and thus the function of the enzyme.
Wiki.
This is probably easier to understand:
Undermethylation is also responsible for what is known as “trinucleotide repeat disorders.
The bases are arranged on our genes in sequences of three, or “trinucleotide repeats.”
But unless those three-base sequences are methylated,
they will repeat themselves as much as a thousandfold, creating various serious conditions, such as Friedreich’s ataxia, Fragile X and Huntington’s disease,
depending on which sequences are repeated.
When there is insufficient methylation and these three-base sequences repeat themselves into very long sections,
they also attract the
limited number of methyl groups that are available,
[ 04-26-2014, 01:54 PM: Message edited by: Marnie ]
Posted by Razzle (Member # 30398) on :
I think they'd have to be cytosol RNA...since one copy of each methylation gene comes from each parent (I think mitochondrial genes come only from the Mother), right?
Still trying to process the new info on PQQ & insulin signaling...
Posted by Marnie (Member # 773) on :
I'm working hard at processing this all too!
Once again edited as you were typing.
Is it possible the mitochondria are "sacrificing" the amino acids they need for their RNA to supply carbon...to make glucose...to keep the cell viable?
I forgot about the mother supplying the mitochondrial...
Specifically...
Mitochondrial DNA (mtDNA or mDNA)is inherited solely from the mother. Wiki.
Posted by sixgoofykids (Member # 11141) on :
Dr. Terry Wahls (not a Lyme doc, she's a Phd) gave a TED talk on "Minding your Mitochondria". She cured her very severe MS with diet focused on healing/feeding mitochondria. It's very scientific.
I found taking on some of her suggestions to be life-changing, particularly the 3 cups per day of greens and the 3 different colors of fruits/vegetables. It's worth the time to watch.