I could have sworn I read or hear once that over 100 antibiotics don't kill Lyme in a test tube. I'm thinking 130 or something. Does anyone have a link to this research? I can't find it for the life of me.
Thanks.
Posted by Tincup (Member # 5829) on :
See email I sent so you will have the direct links. Or click on this link to get to the same list with links.
Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library. Feng J, Wang T, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. Emerg Microbes Infect. 2014 Jul;3(7):e49. doi: 10.1038/emi.2014.53. PMID: 26038747 Free PMC Article Similar articles
Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Antibiotics (Basel). 2015 Sep 16;4(3):397-410. doi: 10.3390/antibiotics4030397. PMID: 27025631 Free PMC Article Similar articles
Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. Feng J, Auwaerter PG, Zhang Y. PLoS One. 2015 Mar 25;10(3):e0117207. doi: 10.1371/journal.pone.0117207. PMID: 25806811 Free PMC Article Similar articles
Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection. Feng J, Shi W, Zhang S, Zhang Y. Emerg Microbes Infect. 2015 Jun 3;4:e31. doi: 10.1038/emi.2015.31. PMID: 26954881 Similar articles
Persister mechanisms in Borrelia burgdorferi: implications for improved intervention. Feng J, Shi W, Zhang S, Zhang Y. Emerg Microbes Infect. 2015 Aug;4(8):e51. doi: 10.1038/emi.2015.51. No abstract available. Erratum in: Emerg Microbes Infect. 2015;4:e56. PMID: 26421273 Free PMC Article Similar articles
Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime. Feng J, Weitner M, Shi W, Zhang S, Zhang Y. Front Microbiol. 2016 Feb 10;7:62. doi: 10.3389/fmicb.2016.00062. PMID: 26903956 Free PMC Article Similar articles
Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing. Feng J, Zhang S, Shi W, Zhang Y. Front Microbiol. 2016 Nov 4;7:1744. PMID: 27867375 Free PMC Article Similar articles
A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library. Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. Front Microbiol. 2016 May 23;7:743. doi: 10.3389/fmicb.2016.00743. PMID: 27242757 Free PMC Article Similar articles
Posted by susank (Member # 22150) on :
Resistant to or not sensitive to?
I thought I had read that Bb does not become resistant to Abx it is sensitive to.
Don't quote me on that.
(not really sure what you're looking for/asking).
Posted by me (Member # 45475) on :
Thanks so much, Tincup and SusanK. Now that you mention it, SusanK, I'm not quite sure what I'm asking for exactly either. I mean, I do, but I don't.
I think I'm asking how many antibiotics and/or antibiotic combinations have faileded to kill b. Burgderfori in a test tube? Yes, I think that is what I'm asking. Posted by Tincup (Member # 5829) on :
Bad part in this deal is not that she is nuts, we can accept that.
But I understood what she was saying!
Doesn't say much for me, does it Susank? HA!
Posted by me (Member # 45475) on :
Yes, I think I'm saying how many antibiotics and antibiotic combinations total have failed to eradicate b. Burgderfori? Dying to know.
Posted by Tincup (Member # 5829) on :
The studies will tell you. You'd need to read them as it is over 100 of them. Some only kill the spirochete form, some only kill the other forms. And remember, that is in a test tube.
I remember them all, but I refuse to tell you and make it easy for you unless you send me $22 billion dollars.
How do you like them apples?
Posted by bluelyme (Member # 47170) on :
Tc would you use that money on abx that dont work or other things?
Me , in the summit it was sain lyme had 26 peptides where strep had 5...some believe diflucan makes the efflux pump of spirochete ineffective thus making it succeptable to abx ... did you have gains on the iv flagyl?
Posted by susank (Member # 22150) on :
I'll play.
"me" - you are thinking about something.
What?
Do you know what you want to know and why you want to know it?
Posted by Tincup (Member # 5829) on :
Blue said... "Tc would you use that money on abx that dont work or other things?"
Well, 22 billion dollars buys a LOT of ice cream and the freezers to hold it all, so I'd probably use it on a number of other things.
And besides, I've already spent 1/2 that much on drugs, supplements, OTC items and other things that don't work.
Ice cream is next on the list!
Posted by Tincup (Member # 5829) on :
And pizza too!
Posted by me (Member # 45475) on :
Okay, you big group of rabble rousers.
Blue--thanks so much for the valuable info.
Tincup-- Are you saying read EVERY study or just the studies you sent (which I did, many thanks again), which would give me a round-a-bout number if I added the drugs from the studies you gave me.
SusanK, Yes, I am asking for a reason. It's a top secret clearance reason. Something percolating in my head right now.
Tincup, Should we plan an intervention for your ice cream problem?
Posted by TrekCoord (Member # 48888) on :
Glad that someone put up a link with the info. I tried doing just a google search and it was fruitless.
I am interested in the 26 vs 5 [strep] thing. No wonder ducks don't want to deal with chronic LD - it's too hard and by and large docs don't like hard, they want to solve with one or two meds.
On a side note, I'll take a tithe on the $22 billion!
![[loco]](graemlins/loco.gif)
![[Big Grin]](biggrin.gif)
![[lol]](graemlins/lol.gif)
![[Wink]](wink.gif)
Something percolating in my head right now.