I think this may have been discussed before, but........
Do anti-inflammatories, specifically cox-2 inhibitors like Celebrex affect antibiotic treatment? I've been on Celebrex for over 10 years for arthritis which I now believe was Lyme-related. I took the max dose 400 mg/day for years. It was the only non-narcotic that worked for me.
Now I'm thinkng that if inflammation is being inhibited, that means blood flow to affected joints is being diminished. Wouldn't this be a bad thing, if you're trying to get antibiotics into tissues?
Also, wouldn't a baby aspirin a day to thin the blood be a good idea?
Posted by lostgurl (Member # 19293) on :
As far as I know, the Cox 2 in hib and any antiinflammatory can cause false negatives on a WBlot but not really affect antibiotic absorption.
Would have to double check that but you raise an excellent question indeed.
A baby aspirin is good for general blood thinning and protects you 'in case' of cardiovascular issues..
All NSAIDS and antiinflammatory drugs (not just steroids) are temporary as we know, they inhibit the immune system, and only mask more symptoms that could help us as diagnostic tools.
The body does become quite tolerant to any antiinflammatory or cox 2 inhibitor such as Celebrex.
In cases of all infectious diseases, fighting or trying to fight off the invading bacteria causes the body to have an abundance of CICs-
circulating immune complexes, that are clumps of proteins left 'over' due to the battle/attempt to rid of the 'foreigh body' aka Bb or other bacteria..
. Anti inflammatories some how keep the bodies immune system suppressed enough to have these CICs linger long afer the bacteria has been eradicated with antibiotic treatment-
no mention of them being 'bad' with abx but it does say that 'systemic' enzymes are best for anti inflammation needs..
Basically it's a whole new approach to reduction of inflammation and healing.
Is there anything you could switch to or try (I know you have tried alot) taper the Celebrex down and then look into an alternative to even an NSAID? May be worth it.
I hope that at least helped a little:)
Posted by paulieinct (Member # 17514) on :
Thanks lostgurl, I guess I wasn't aware of the effects you mention, like immune suppression, and false negatives on WB.
I did stop Celebrex completely 1 week ago, and started something called Wobenzym-N, a German product consisting of various enzymes. Long story short, I em expeiencing probably the worst joint pain I've ever had, all joints: neck, shouldders, wrists, hands, knees, ankles, back. My LLMD told me that Wobenzym may be able to dissolve the biofilm which surrounds aggregates of spriroketes, protecting them from abx and immune system.
So from what you say, Celebrex could have been impeding my recovery. Interesting.
Posted by Keebler (Member # 12673) on :
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Pharmaceutical anti-inflammatories often have serious side effect and, in that case, can hurt patients' chance of success.
NSAIDS are especially dangerous on several levels.
However, there are many natural anti-inflammatory agents (and FOODS) that can help. Enzymes, colorful foods, etc.
Turmeric, curcumin, etc.
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Posted by swachsler (Member # 18155) on :
What about other (nonanti-inflamatory) forms of pain treatment -- do they affect treatment outcome?
Like opiates or tylenol?
Do they have the same effects?
-Sharon
Posted by Keebler (Member # 12673) on :
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Tylenol is very hard on the liver. VERY hard.
Optiates, too, are not easy for the liver but I've not done research about that.
you can read more about how the liver processes stuff here: