tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
I was looking back at some of my test results from 2009 and saw that my folate and B12 levels were high. Does anyone know what could cause this?
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
Tammy N.
Frequent Contributor (1K+ posts)
Member # 26835
I'm still trying to sort it out.
Posts: 2238 | From East Coast | Registered: Jul 2010
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
IF you can't PROCESS them, they might remain high.
MTHFR gene problem impacts the ability to convert folate = folic acid to its useful form.
B12...if your stomach lacks a certain factor called intrinsic factor, you can't absorb B12. This can also be a genetic problem.
Those 2 genetic factors together = major problem.
But there are "work arounds"...taking the active form of folic acid (Deplin or FoloPro)and sublingual B12...though it is likely sublingual B complex would be an even better idea.
Folic acid (B9) and B12 are used to reduce homocysteine (toxic).
B6...once again, active form is PLP/P5P, helps in a jam (lowers homocysteine) if B12 dives or can't be absorbed or if the active form of folic acid isn't available.
Just because folic acid/folate and B12 are THERE, doesn't mean you can USE them.
UMFA = *unmetabolized* folic acid...test can be run.
Along with 5-MTHF (test)
For those with bipolar, here's one recommendation:
If those with bipolar take niacin (vitamin B3) along with 5-MTHF, B12, TMG and B6, will the mania not occur?
(FIVE supplements?)
Biochemistry shows this possible. Is it clinically? According to those who practice functional and orthomolecular medicine � yes.
Personally, the above may need to be improved upon for SOME persons i.e., the sublingual forms of the B vitamins/B complex sublingual.
It's available. Source Naturals.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
The Source Naturals version uses folic acid instead of methyl-folate... I've seen this in other "coenzyme" B complexes too... Would be nice if they'd update their formulas with methyl-folate...
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
LLMD told me today regarding MTHFR, I have 2 "C copies". Anyone know what exactly this means?
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
Which one is considered the "C copy"? C677T or A1298C?
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Tickled, it is the A1298C that is considered the "C copy"...
The first letter is what it is supposed to be, the number is the location on the gene, and the second letter is the mutated version. So when referencing MTHFR C, it will mean the A1298C mutation (at location 1298, the A has been switched to a C).
Does that help?
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Razzle, thanks for the clarification!
BTW...Hsp90 (heat shock protein) apparently goes up early in lyme and late in lyme. This looks to be an attempt to raise an enzyme called BH 4 . Those with the MTHFR defect make a limited supply of that beneficial enzyme.
BH4 is an enzyme that is used to make serotonin, dopamine, thyroid hormones, melanin and to
detox ammonia.
AND...it takes Mg (somewhere along the route) to make ALL of our enzymes.
And as we know, Mg levels drop "significantly" (understatement) at the outset of lyme.
So...double whammy impacting the ability to make that beneficial enzyme.
Since we DO absorb things thru our skin, MgCl IS available for topical application (it might burn a little for a very short time...not on me...I'm not "significantly" deficient).
Re: sublingual...I know B12 and B6 are available by themselves. And as far as B3 goes (niacin)...NADH comes from niacin.
NADH sublingual is available from Source Naturals too (I have NO CONNECTION to that company or any other!). It is used for chronic fatigue, jet lag, etc.
I got some to try at Max Wellness yesterday. I don't have lyme (my sis was dx'd.). Anyway, ONE sublingual tablet did not effect me at all. So this morning I tried 2 tablets (20mg total...2, 10mg). So far I can't really say I feel any different.
While at the store, I was talking to the owner (very knowledgeable) and he said CoQ10 LOWERS NADH.
We MAKE CoQ10 (provided we have the nutrients to do so) when we EXERCISE. Keep in mind, it LOWERS NADH. And even the most healthy athletes have low NADH levels.
So...when you are better and CAN exercise, to STAY healthy and lower NADH which Bb likes..is recommended.
NADH is in our mitochondria (powerhouses) and I linked elsewhere that this is one of Bb's favorites.
So, if Bb is "stealing" NADH (which we make from naicin) which is in our mitochondria (powerhouses), and the macrophages (think of them as pac-men) are trying to destroy Bb, but he is stealing the macrophages' supply of NADA =
they lack the energy to finish their job due to "mitochondrial dysfunction"?
So...do we take CoQ10 and lower NADH levels (making less available for Bb)? OR...
Do we TAKE EXTRA NADH to try to help out the macrophages?
Should we change the above bipolar recommendation (if one has the MTHFR defect) to:
NADH (sublingual), B6 as sublingual PLP/P5P, sublingual B12 (only if it seems you lack the "intrinsic factor"...have gastritis?), plus FoloPro/ Rx Deplin and TMG?
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
Yes Razzle, that helps tremendously! Thank you.
Marnie, I will have to read that again when I have more brain power.
Posts: 2541 | From Northeast | Registered: Jan 2008
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic