The most common cause of intracranial large-vessel stenosis is intracranial atherosclerotic disease.
3 Other less common causes are primary angiitis of the CNS, a rare and poorly understood form of vascular inflammatory disease restricted to the brain and spinal cord, and secondary vasculitis of the CNS.
These are a heterogeneous group of disorders characterized by blood vessel inflammation, producing different but frequently overlapping clinical manifestations. Histologic changes allow classification according to the size of the vessel implicated.
These include giant cell arteritis, polyarteritis, and systemic vasculitis secondary to Wegener granulomatosis, systemic lupus erythematosus, Sj�gren syndrome, collagen diseases, and those associated with neurocutaneous syndromes or malignancy (leukocytoclastic vasculitis, intravascular lymphoma).
Other noninflammatory vasculopathies to consider include vasospasm (cocaine-induced, reversible cerebral vasoconstriction syndrome), infections (Lyme disease, meningovascular syphilis, and HIV-associated infections), and hematologic conditions
However, improvement in both cognitive function and SPECT perfusion have been well-documented following EC/IC bypass, suggesting that a group of carefully selected patients may benefit
-------------------- 2 Corinthians 12:9-11
9 But he said to me, �My grace is sufficient for you, for my power is made perfect in weakness.� Therefore I will boast all the more gladly about my weaknesses, so that Christ�s power may rest on me. Posts: 1445 | From Poconos, PA | Registered: Jul 2004
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poppy
Frequent Contributor (1K+ posts)
Member # 5355
posted
I am doubting their statement that lyme would be a noninflammatory vasculopathy. The few studies that have looked at this are suggesting it is inflammatory.
Posts: 2888 | From USA | Registered: Mar 2004
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Pocono Lyme
Frequent Contributor (1K+ posts)
Member # 5939
posted
I agree poppy. My SPECT report states: moderate heterogeneity of perfusion to the cerebral hemisphere. The perfusion is dimished moderately bilaterally. This finding may be seen in vasculitis and may also be compatible with Lyme disease.
Impression: Findings compatible with Lyme disease or other Vasculitis.
Not vasculopathy.
Although when I think about it, if angiogenesis is involved, then maybe not? This has been mentioned in relationship to CCSVI also.
I may ask my PCP on next visit to order vascular studies. I can find no other effective treatment and prognosis is grim.
-------------------- 2 Corinthians 12:9-11
9 But he said to me, �My grace is sufficient for you, for my power is made perfect in weakness.� Therefore I will boast all the more gladly about my weaknesses, so that Christ�s power may rest on me. Posts: 1445 | From Poconos, PA | Registered: Jul 2004
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