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» LymeNet Flash » Questions and Discussion » Medical Questions » abx, leaky gut and diabetes

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Author Topic: abx, leaky gut and diabetes
TerryK
Frequent Contributor (5K+ posts)
Member # 8552

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Just wanted to relay my experience here in case it helps anyone else or in case anyone has anything more to add.

abx can cause leaky gut

parasites can also cause leaky gut

leaky gut = lots of allergies with new ones developing all the time

if diabetic leaky gut probably means increased blood sugars

I noticed everytime I take abx my blood sugars get very high and hard to control. I also started to develop allergies to many meds and supplements. Usually my blood sugars would go back to my baseline after a few weeks off abx but this last time they did not and I had to move my insulin up and I am still not able to control my blood sugars.

I finally figured out that my problem seems to be caused by abx causing leaky gut. Something I healed at one time but have struggled with for years.

My diabetes doctor kept telling me there are only a few abx that cause increased blood sugars for diabetics and the latest one is not one of them so he does not believe this is a factor.

I did a search to see if there was a relationship and it seems that there is.


Obes Rev. 2011 Jun;12(6):449-58. doi: 10.1111/j.1467-789X.2010.00845.x. Epub 2011 Mar 8.

Leaky gut and diabetes mellitus: what is the link?

de Kort S, Keszthelyi D, Masclee AA.

Source
Department of Internal Medicine, Division of Gastroenterology-Hepatology, Maastricht University Medical Centre+, Maastricht, the Netherlands.


Abstract

Diabetes mellitus is a chronic disease requiring lifelong medical attention. With hundreds of millions suffering worldwide, and a rapidly rising incidence, diabetes mellitus poses a great burden on healthcare systems.

Recent studies investigating the underlying mechanisms involved in disease development in diabetes point to the role of the dys-regulation of the intestinal barrier.

Via alterations in the intestinal permeability, intestinal barrier function becomes compromised whereby access of infectious agents and dietary antigens to mucosal immune elements is facilitated, which may eventually lead to immune reactions with damage to pancreatic beta cells and can lead to increased cytokine production with consequent insulin resistance.

Understanding the factors regulating the intestinal barrier function will provide important insight into the interactions between luminal antigens and immune response elements.

This review analyses recent advances in the mechanistic understanding of the role of the intestinal epithelial barrier function in the development of type 1 and type 2 diabetes.

Given our current knowledge, we may assume that reinforcing the intestinal barrier can offer and open new therapeutic horizons in the treatment of type 1 and type 2 diabetes.

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