Jordana
Frequent Contributor (1K+ posts)
Member # 45305
posted
I'm supposed to bump up my Bactrim dose to really a lot of Bactrim.
I'm not afraid of it, but I've read a person shouldn't take it if they have a folate deficiency. I don't have a folate deficiency but I'm wondering if I should be supplementing if I'm taking like a crapload of Bactrim.
Anyone know? The literature is a little murky.
Posts: 2057 | From Florida | Registered: Feb 2015
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TNT
Frequent Contributor (1K+ posts)
Member # 42349
posted
I would definitely start taking, or increase your intake, of methylfolate. Bactrim works by inhibiting the methylfolate absorption of the bugs, but it also inhibits the host's methylfolate uptake too.
So, I would think it should be taken between Bactrim doses. I've often wondered if increasing folate intake will just cancel out the Bactrim's effect, but I don't think so, as they do recommend that children with folate deficiencies who are on Bactrim supplement with folate.
I don't have sources for this off-hand, but I remember reading pubmed articles about it.
Posts: 1308 | From Eastern USA | Registered: Oct 2013
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Jordana
Frequent Contributor (1K+ posts)
Member # 45305
posted
I read a lot of them too but it was never clear to me if it was only stopping folate synthesis in the bugs or if that extended also to me. I feel like I've seen both suggested.
I am supplementing some with a multi; guess it's good to do just in case.
Posts: 2057 | From Florida | Registered: Feb 2015
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Phoiph
Frequent Contributor (1K+ posts)
Member # 41238
posted
Jordana...
I'm a little confused...could you clarify?
You recently posted that although your recent blood smear for other coinfections was clear, you previously tested positive for Ehrlichia:
Why, then, would you be taking Bactrim, and considering "bumping up" your dose to "really a lot"?
Posts: 1885 | From Earth | Registered: Jul 2013
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Jordana
Frequent Contributor (1K+ posts)
Member # 45305
posted
I've already taken a lot of minocycline and I'm also taking doxycycline now.
I think the doc thinks I have babs based on my symptoms. Funny thing, I'm not really herxing on it or the doxy so far.
Posts: 2057 | From Florida | Registered: Feb 2015
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