This week has been a flood of depression and tremors. Went to LLMD last week. New Rx protocol...clinda IV 900mg 2x's/day,5days...zith IV 500mg 2days...mino 100 mg bid. Bad herx this weekend, and stopped mino for weekend re dr instuctions.

Going onto 6 month of rx....had hoped to be done by now, or atleast done iv's by May. Not the story now. No timeline, and I'm crashing emotionally.

Please tell me something hopeful.

Wanting to start support grp in NH cuz I need it but also so no one else has to do without... Don't know if I can. I'm kinda sick! Sad and overwelmed are big right now too... Hoping it will get better after these rx do their work in my brain.

This would effect both mood and pain, in addition a breakdown also increases homocysteine which is a toxin unto itself.

If I were you I would take a look at your GI tract, do some cleansing and detoxing, and see if that helps. It is also important to take a look at your diet. Eating the right foods to help the methylation process is just as important.

I'm doing my am infusion...it feels like it's going right to work,,,,ugh! It's funny, I was thinking "get the infusion done and then do......"a list of things. Somehow often, that drip starts and my brain goes into space. I hope the positive feelings stay around.

hwlatin.... Interesting thought abt GI wellness and emotion. My appetite is low. Holding fluid in intersistal tissue, though with herx this weekend, I was sweating like a pig.

Taking lots of probiotics, and Gi tract has been pretty good. Diet is low/no carb, high protien, good fats and vegies (organic grain fed, etc)...little fruit, although with depression comes with no appetite, and I lure it back with pudding, and or sweet potatoe.... gotta do something.

Good advice from the others, especially about the GI tract. I was put on an anti-depressant to help stimulate my appetite. I had never heard of this. But, my PCP explained the whole seratonin/gut relationship and how an unhealthy gut causes a decrease in the seratonin uptake capabilities of the gut, where we have lots of neurotransmitters. I may not be 100% correct in how I described that but, you get the idea.

While repairing my gut and taking the anti-depressant I was feeling better slowly. I am now almost off of the anti-depressant, which is a withdrawal struggle. But, my appetite is still good.

Also, My Lyme MD mentioned that Clinda IV is something I might not tolerate well, given my current size and tummy problems. I trust that he has good reson to believe this med can be very tough to handle.

So, hang in there. Be somewhat complacent with the knowledge that the depression seems to come and go. That means your body is still working to keep you happy and balanced. If you get to the point where you feel theres is a constant dark cloud surrounding you, then I would speak to your MD about Rx to help that. Although support groups are re-assuring, I have avoided them because I don't necessarily want my misery re-inforced. I have chosen to surround myself with healthy and recovered folks to keep my focus on getting better. I use Lymenet for my support and wealth of treatment information.

This is only my opinion.

I'll ask all abt my gut this week.

DO NOT want ssri"s! I've had really bad time with that...never want to go there again! Talk abt depression!

All of these things effect absorption and in turn effect the Methylation process. I know how hard it is. It has taken me three years of solid treatment, before I have gotten it under control, but the encouraging thing is that my depression is now under control with out drugs specific to depression.

I will tell you when I am herxing I do notice that the depression does creep back in a little bit, but goes right away. I am sure it is a temporary balance issue now.

One more thing, since you are already on IV, The best thing I have encountered is Glutathione. I do IV pushes 3 times a week 2g each time. This has been amazing stuff, helps detox and spreads the serotonin and dopamine in the brain. This has really helped me alot. I feel that I finally have my brain back.

I will tell you though for two weeks really enhanced my Herx, but I stuck with it and after that Herx I felt the best I have felt in 8 years. I am in the middle of another Herx, this one is alot more managible, but I highly reccomend. Single handly might be the best thing I have taken next to the Mepron.