This is a documented website in "our" favor...PROVING this disease can indeed become chronic and more importantly...WHY!
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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-------------------- Every experience God gives us, every person He puts in our lives, is the perfect preparation for a future only He can see....Corrie Ten Boom Posts: 343 | From Northcentral Iowa | Registered: May 2005
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posted
Getting chronic inflammation down is key to 3 different Lyme approaches: 1) Marshall Protocol using Benicar 2) Cowden protocol using Cumanda� Extract for its anti-inflammatory, analgesic and immune regulatory properties. 3)This approach using agents( like Melatonin & MgCO3 & others) to minimize activation of NF-kappa-B by maximizing NO(I think that is what Marnie is talking about.pls correct me if I am wrong!)
All 3 approaches are addressing a factor that the abx only route appears to ignore. This might be the silver bullet we have been waiting for. Lets hope! Ernie
Posts: 546 | From Cascadia subduction zone | Registered: Mar 2002
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5dana8
Frequent Contributor (1K+ posts)
Member # 7935
posted
Marine thanks for posting this information
This might be the holy grail but may as well be in chinese.
Looking forward to anyone that still has their gray matter intact to help explain this article.
Please to explain like you where trying to explain how to drive to an alzheimers patient
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Bb activates an enzyme that keeps the cells it is hiding in from their normal pre-programmed cellular death.
Since Bb looks to hang out in the epithelial cells that line the blood vessels and lymph nodes...I'd be curious as to what those cells' programmed cell death time is...anyone know? How long are they supposed to last before being replaced?
TNF alpha is upregulated to try to destroy the cells where Bb is hiding out in.
To INactivate that enzyme (NFkB) which is prolonging the life of that cell, it looks like nitrogen is really important...or nitric oxide...
Melatonin contains an indole...the "working part"...H=N (that's hydrogen double bonded to nitrogen).
Melatonin works by stimulating the intestines to release bicarbonates.
Bicarbonates help us retain nitrogen.
It looks like plant indoles (plants absorb nitrogen...animals eat plants...humans eat both to get nitrogen)...work another way too:
" Inhibition of acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives."
So...indoles INhibit an enzyme called (abreviated) ACAT...and they lower cholesterol (the bad kind)...
Guess which bacteria utilizes ACAT to make it's cholesterol cell wall...
Note: Nitrogen...bicarbonates...becoming more alkaline...
Now...the article hints at another possiblity...did you catch it...it is a specific amino acid which is linked to the OTHER neurotransmitter...norepinephrine...
In the BODY...the 2 main neurotransmitters are: acetylcholine and norepinephrine.
Following now?
[ 10. July 2006, 03:16 PM: Message edited by: Marnie ]
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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even your "simplified' versions of information usually go way over my head!
-------------------- "Looks like freedom but it feels like death.. It's something in between, I guess"
Leonard Cohen, from the song "Closing Time" Posts: 822 | From California | Registered: Jan 2006
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ConnieMc
Frequent Contributor (1K+ posts)
Member # 191
posted
How much melatonin can you safely take? I read in a nutrition book about treating cancer with nutrition that they recommended 20 mg. melatonin. Typically supplements contain 3 mg. and instruct you to take 1. After reading that, I ultimately increased it to 9 mg. This helps me a great deal and certainly seems safer then the Ambien I was taking.
Anyone have any idea?
Interesting connection. I forwarded this and the up,up,up post on to my LLMD and credited you, Marnie. I love it that someone is so much into the biochemistry of it all. Keep up the good work.
Posts: 2276 | From NC | Registered: Oct 2000
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GiGi
Frequent Contributor (5K+ posts)
Member # 259
The aim of this study was to ascertain and analyze the efficacy of various "brain entrainment" audio tapes produced by Acoustic Brain Research.
These tapes, it is claimed, assist in stimulating alpha and theta brain waves in test subjects by alerting the Reticular Activating System (RAS) to incoming signals and activating the cerebral cortex.
Techniques by which ABR claims to facilitate such changes in the brain are: Threshold Electronic Pulsations, frequency modulations, musical patterning, tonal architecture and hemispheric spanning.
----------------------
I have used acoustic brain research tapes years and years ago. I cant figure out where I put them though.....
They provided me discernable cognitive effects (I was in grad school at the time) for a few hours. I think they are best used with earphones for binaural stimulation, left-right brain patterning, and blocking out background noises.
Tom Kenyon and ABR are not related, but both are real big names in use of sound waves for healing, etc. (edit: yes they are related, ABR I think was his first scientific foray in scientific foundations of sound healing. He now seems to be more into metaphysical healing aspects of it. )
Over the years, I have become more impressed with the use of sound in affecting the body/mind.
For example, Pachebel's Canon D is extremely peacefully uplifting. Mozart (yes, there are studies) seems to ping the brain into activity (cant figure ot the right words).
Most contemporary/country music is anger/sorrow oriented, causing disturbance/twisting in the energy field.
Northstar
[ 12. July 2006, 08:01 AM: Message edited by: northstar ]
Posts: 1331 | From hither and yonder | Registered: Sep 2005
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
GREAT find Gi Gi!
For those gluten intolerant...heads up.
There is dandelion again! Known to reduce cholesterol!!! Want a list of what nutrients are in the leaves, roots and tips? WOW...restore the balance.
Question: are our own beneficial bacteria "nitrogen fixing". Do THEY help us retain nitrogen? I suspect so.
Okay...let's see if you can catch onto this:
Doctors will read the TITLE and understand:
*NF-kappa B activation*
TNF and interruption of apoptosis (programmed cell death)
seem to play an important role in persistence of most
chronic INTRACELLULAR INFECTIONs
**********
What this is saying is Bb activates an enzyme to halt cell death.
Meanwhile TNF alpha is upregulated to try to cause cell death, but doesn't work.
We need to INactivate the enzyme NFkB (along with PFK and HMG CoA reductase).
We can do this! It all has to do with nitrogen or perhaps L-tyrosine.
Melatonin contains an indole. This is a H=N (hydrogen double bonded to nitrogen). It is belived indoles are the main "working part" of melatonin.
Now...look closely:
Biochem Pharmacol. 1994 Jan 20;47(2):359-64.
Hypocholesterolemic properties of plant indoles.
*Inhibition of acyl-CoA:cholesterol acyltransferase activity*
and reduction of serum LDL/VLDL cholesterol levels
by glucobrassicin derivatives.
acyl-CoA:cholesterol acyltransferase activity or ACAT...is something Bb has in it's genetic makeup (linked below).
Indoles INactivate that enzyme.
Also, our urine contains the EXCESS nitrogen we don't need...along with ammonia. These make our system more alkaline.
Drinking one's own urine...the benefit has nothing to do with antibodies (most of which are damaged), but does have to do with recycling nitrogen...and ammonia.
Acetylcholine (ACh) is a simple molecule synthesized from choline and acetyl-CoA through the action of choline acetyltransferase.
Looks like Bb maybe "upregulating" acetylcholine.
And:
"Acetylcholine
cholinergic agonist and neurotransmitter at the myoneural junction of striated muscle and at the preganglionic sympathetic and parasympathetic synapses.
*It is the main
agonist
of nitric oxide."*
Melatonin is it's "counter" in the brain. Norepinephrine is the body and brain's counter.
Tyrosine is linked to the thyroid hormone...and to norepinephrine.
Thyroxine (T4 ) is a derivative of the amino acid tyrosine with four atoms of iodine. In the liver, one atom of iodine is removed from T4 converting it into triiodothyronine (T3). T3 is the active hormone. It has many effects on the body. Among the most prominent of these are:
an increase in metabolic rate (seen by a rise in the uptake of oxygen);
an increase in the rate and strength of the heart beat.
I have a lot more research to do on L-tyrosine, but it is involved in norepinephrine production...
WARNING!!!
L-tyrosine is NOT to be taken if you have melanoma (a type of cancer).
This all looks to be related to light too...
IF you have a virus, if the Th2 pathway is upregulated, blue light exposure looks to help.
IF you have a bacterial infection, if the Th1 pathway is upregulated, red light exposure looks to help (as far infrared).
For those of you who are interested in color, frequencies, wavelengths...to learn = to increase your neuroreceptors:
Now you might BEGIN to understand at least a little about how we can apply the use of frequencies...sound waves to help us heal.
The fact that listening to Mozart has been PROVEN to increase dopamine shows how powerful sound can be (beneficial or harmful).
We know that sounds too LOUD, can cause permanent ear damage...over time...and it has nothing to do with rupturing the ear drums.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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5dana8
Frequent Contributor (1K+ posts)
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posted
Thanks Marine,northsatr and gigi
For translateing this article. It still is somewhat ovet my lyme head but I think if I re-read it many more times it may make some sense.
marnie: How do we safely get more nitrogen/bicarbonates into to our bodies safely?
re: melatonin- I take 3 mg at night. If a person where to take more durning the day -how to combat the sleepiness?
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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5dana8
Frequent Contributor (1K+ posts)
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posted
Wallace
I may be missing something but not sure I saw any links or posts relateing to urine therapy>?
-------------------- 5dana8 Posts: 4432 | From some where over the rainbow | Registered: Sep 2005
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johnnyb
Frequent Contributor (1K+ posts)
Member # 7645
posted
Ok, so I keep looking this over and looking it over.....
Put very simply, I think it seems to mean that anything that would increase production of nitric oxide in the body might be beneficial in fighting lyme.
Certain supplements (amino acids), light, sounds, whatever would increase NO could help.
Correct me if I'm wrong.
Posts: 1197 | From New Jersey | Registered: Jul 2005
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This is all very interesting. Most of us are not biochemists, so the technical implications can be a little difficult to grasp.
Do you remember the mushroom Coriolus that was recommended a few weeks back by one of our dear LLMD's? She said it has been making patients feel better AND causing their CD-57's to shoot up?
I read some of the research on it, and one of its mechanisms mentioned in the context of cancer treatment was restoring the normal function of programmed cell death... the very thing you are telling us about.
I've been taking it, and I can tell you that is is definitely doing SOMETHING. I am not quite sure what that something is yet, but it feels like it is something profound.
You might want to take a look at what research is out there on Coriolus Versicolor. I think the Japanese have been doing most of it.
I think there is a connection to what you are trying to explain to us.
Regards, James
Posts: 714 | From San Antonio TX | Registered: Oct 2004
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posted
Marnie, By drinking sodium bicarb, would that increase nitrogen? I've been studying why Nov.2, when I drank 7 tsp. sodium bicarbinate in oj, that my deep seated burning ache in my head went away after 11 1/2 years constant.
Posts: 290 | From ohio | Registered: Dec 2005
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posted
Up
Posts: 59 | From Canada | Registered: Mar 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Citrates convert to bicarbonates...look closely at labels while you are in those nutritional supp/health food stores.
The mushrooms, Cat's Claw, etc. hit Bb from the glycolysis angle only...will help, yes, cure, I don't think so.
Looks like hitting from the cholesterol angle is more important. Step #1 in lysing (breaking apart) a gram neg. bacteria...weaken or prevent the cell wall formation. This weakens it. Halt cholesterol production in the liver. We will get good fats (chose carefully) from our foods (we need some cholesterol!)...just stop the excess VLDL production.
Both the glycolysis (sugar) and cholesterol pathways can be hit simultaneously. That does NOT translate to "once a day" Mg.
When ill...a little more often...nutrient wise... is the best approach.
There IS more than one way that works. Like everything in life...more than one path to reach a goal.
We are all here working TOGETHER talking about what works, what doesn't and (me) why.
But...keep in mind...you CAN get well!!!
Never, ever stop believing this!
Are you gonna let a tiny bug outsmart you?
Naaaaaaaaaaaah!
P.S. I am not advocating urine therapy...the thought makes me nauseated, but...I understand the basis.
We are in a specific nitrogen deficiency. One or more of the amino acids is off. This pathogen is using a LOT of our nutrients. The whole body is out of balance.
This disease = very acidic, very toxic.
Need to get alkaline.
I posted what works to INactivate NFkB...the "messenger" that Bb is using to make lyme chronic.
I have also posted what I take...to stay healthy and hopefully "younger" ;-) . Okay...once again...d-ribose, Juvenon, lecithin, and CoQ10.
I have posted what I would do IF I had lyme...exactly which supplements, diet, treatments and lifestyle changes (shoot...I love Pepsi!).
I know it will take time, but I know it IS possible to conquer this disease!
Wishing you all a safe journey back to complete health.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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posted
This is very interesting--I can speak from an MS perspective on two fronts.
Apotosis-in a study (I can post it if anyone wants it)researchers were surprised at the "age" of immune cells in MS patients. Something was causing them to remain alive longer than in healthy controls.
LDL- Many people with MS have shown improvement when treated with Statins (cholesterol lowering drugs) These are both anti-inflammatory and anti-bacterial. Is this the type of cholesterol lowering you're talking about, Marnie?
Posts: 554 | From Naples, Italy | Registered: Jun 2006
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