* Jelic TM, * Chang HH, * Roque R, * Malas AM, * Warren SG, * Sommer AP.
Department of Pathology, Charleston Area Medical Center, West Virginia University, WV 25304, USA. [email protected]
Calcific aortic valve stenosis is the most common valvular disease in developed countries, and the major reason for operative valve replacement.
In the US, the current annual cost of this surgery is approximately 1 billion dollars.
Despite increasing morbidity and mortality, little is known of the cellular basis of the calcifications, which occur in high-perfusion zones of the heart.
The case is presented of a patient with calcific aortic valve stenosis and colonies of progressively mineralized nanobacteria in the fibrocalcific nodules of the aortic cusps, as revealed by transmission electron microscopy.
Consistent with their outstanding bioadhesivity, nanobacteria might serve as causative agents in the development of calcific aortic valve stenosis.
PMID: 17315391 [PubMed - indexed for MEDLINE]
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Dave6002
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Nanobacteria, HIV and magic bullets - Update of perspectives 2005 Author(s): Sommer AP, Milankovits M, Mester AR Source: CHEMOTHERAPY 52 (2): 95-97 2006
Abstract: In 1997 a Finnish group speculated on the presence of nanobacteriain vaccines. In 2001, a report on the identification of nanobacteria in a number of vaccines attracted much attention. Experiments indicated that viable nanobacteria are excreted via urine. Their extreme survivability suggests that prior to discussing any possible contamination of vaccines, sources and routes of natural infection need to be examined. In view of 30,000,000 HIV infections in sub-Saharan Africa, the recently reported occurrence of nanobacteria in HIV-infected patients deserves concern. Clearly, it could indicate the origin of a giant reservoir and dissemination cycle. Here we discuss novel therapeutic strategies to prevent or reduce nano-bacterial infection. In regard of the rapid progress in this field, we start with a brief introductory summary, and analyze possible implications.
Source: Astrophysics and Space Science, Volume 305, Number 4, December 2006, pp. 411-413(3)
Abstract:
The data on the far-ultraviolet extinction of starlight in our galaxy and in external galaxies is interpreted in terms of the widespread occurrence of organic particles of optical refractive index 1.4 and radii less than or equal to 20~nm.
Such particles are candidates for nanobacteria such as recently been found in abundance on the Earth.
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posted
I have posted on this in the past. Hubby has tested positive for nanobacteria every time it has been tested -- 3 or 4 times. He has kidney stones which I think are caused by this.
Can't remember the name of the lab we used. Might have been in one of my previous posts. Hubby only tried the treatment for a month or so -- couldn't tell any difference and we moved on to something else.
Haven't tested nanobacteria in probably 3 years now. Maybe some day will have the $ to test and see if this and the Borna virus and CMV and HHV-6 and EBV are gone. For now just concentrating on tickborne infections.
Treatment for nanobacteria is a proprietary amino acid blend and tetracycline suppositories.
Bea Seibert
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Dave6002
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Somebody on Rife and Lyme forum also stated that he had nanobacteria.
Seems it's very prevalent.
However, don't know if it causes diseases other than kidney stones and artery diseases.
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Truthfinder
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I feel very foolish..... I have no idea what nanobacteria ARE.
Dave, I could not bring up anything with your original link - I keep getting 'error on page' messages. I looked at the other link, and it's interesting, but I'm lacking some basic knowledge of this nanobacteria stuff.
Could somebody provide a brief explanation, or perhaps a link to Bea's previous post about it?
Are nanobacteria something new?
And Bea, you said that a proprietary amino acid blend and tetracycline suppositories are the treatment for this.....
Well, this is rather fascinating, I confess....
Tracy
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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treepatrol
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quote:Originally posted by Truthfinder: I feel very foolish..... I have no idea what nanobacteria ARE.
Dave, I could not bring up anything with your original link - I keep getting 'error on page' messages. I looked at the other link, and it's interesting, but I'm lacking some basic knowledge of this nanobacteria stuff.
Could somebody provide a brief explanation, or perhaps a link to Bea's previous post about it?
Are nanobacteria something new?
And Bea, you said that a proprietary amino acid blend and tetracycline suppositories are the treatment for this.....
Well, this is rather fascinating, I confess....
Tracy
They are 100 times smaller than the smallest virus.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Dave6002
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Tracy, here is the full article:
Are Nanobacteria Making Us Ill? Amit Asaravala Email 03.14.05 | 2:00 AM
Olavi Kajander didn't mean to discover the mysterious particles that have been called the most primitive organisms on Earth and that could be responsible for a series of painful and sometimes fatal illnesses.
He was simply trying to find out why certain cultures of mammalian cells in his lab would die no matter how carefully he prepared them.
So the Finnish biochemist and his colleagues slipped some of their old cultures under an electron microscope one day in 1988 and took a closer look. That's when they saw the particles. Like bacteria but an astonishing 100 times smaller, they seemed to be thriving inside the dying cells.
Believing them to be a possible new form of life, Kajander named the particles "nanobacteria," published a paper outlining his findings and spurred one of the biggest controversies in modern microbiology.
At the heart of the debate is the question of whether nanobacteria could actually be a new form of life. To this day, critics argue that a particle just 20 to 200 nanometers in diameter can't possibly harbor the components necessary to sustain life. The particles are also incredibly resistant to heat and other methods that would normally kill bacteria, which makes some scientists wonder if they might be an unusual form of crystal rather than organisms.
In 1998, Kajander tried to prove the skeptics wrong by turning up what he believed to be an example of nanobacteria's ribosomal RNA, something that only organisms have. But the claim was squashed two years later by a National Institutes of Health study, which found that the RNA was actually a remnant from a type of bacteria that often contaminates lab equipment.
The debate would have ended there, except for a steadily increasing number of studies linking nanobacteria to serious health problems, including kidney stones, aneurysms and ovarian cancer. The studies show that nanobacteria can infect humans, a find that has helped push nanobacteria back into the limelight. Now the pressure is on to resolve the controversy and expose how nanobacteria works -- no matter what it is.
"It's all pretty exciting stuff," said David McKay, chief scientist for astrobiology at NASA's Johnson Space Center. "Whether these are bacteria or not -- it doesn't matter at this point. What matters is if we can figure out the association between nanobacteria and kidney stones and develop some kind of countermeasure."
The link between nanobacteria and human diseases was first noticed by Kajander and microbiologist Neva �ift�ioglu in 1998. The researchers had observed, through an electron microscope, nanobacteria particles building shells of calcium phosphate around themselves. They began to investigate whether such particles played a role in causing kidney stones, which are also made of calcium compounds. Sure enough, at the center of several stones was a nanobacteria particle.
Another breakthrough came in 2003 when a team from the University of Vienna Medical Center discovered nanobacteria in the calcified debris found in tissue samples from ovarian cancer patients. Meanwhile, several other studies revealed nanobacteria in samples of calcified arteries.
Sensing a growing need for tools to detect and study nanobacteria, Kajander and �ift�ioglu formed a company called NanoBac in 1998. The decision was greatly criticized as a conflict of interest and is still brought up whenever either of the two publishes a new paper.
Fortunately for the researchers, a 2004 study by the esteemed Mayo Clinic supported many of their key findings and helped them regain some of their support. The Mayo study found that nanobacteria do indeed self-replicate, as Kajander had noticed, and endorsed the idea that the particles are life forms.
Kajander and �ift�ioglu were further vindicated this February when patients with chronic pelvic pain -- thought to be linked to urinary stones and prostate calcification -- reported "significant improvement" after using an experimental treatment provided by Nanobac Life Sciences, which now owns NanoBac. The study was conducted by a team at Cleveland Clinic Florida.
There's a lot riding on studies like these. Roughly 177,500 patients were discharged from U.S. hospitals with kidney stones and related problems in 2001, according to the NIH. More than 25,000 women in the United States are diagnosed with ovarian cancer each year. In the same period, 14,000 Americans die from complications caused by calcified arteries.
"It brings up a lot of questions," said John Lieske, who led the 2004 Mayo Clinic study. "How many kidney stones are caused by this? Are there other calcification-related diseases that are caused by nanobacteria? Is it infectious?"
Surprisingly, few groups are actually working on answering these questions. One would be hard-pressed to find more than a half-dozen research teams around the globe studying nanobacteria full time.
Lieske suggests it's because the field is still relatively young. But it's clear that there's an additional culprit: the often heated controversy over whether nanobacteria particles are, in fact, alive.
"There's a reluctance to get into controversial areas. It's hard to get proposals funded," said McKay. "Most people are waiting until there's a little more meat on the bones."
Even John Cisar, who led the 2000 NIH study that contradicted Kajander's initial findings, agrees that the issue has become muddled. Though he maintains his stance that nanobacteria are not alive, he said in a phone interview that he is not against further research.
"I'm not saying there's nothing there," said Cisar. "It's just that we were looking at it from a microbiologist's perspective. And when we didn't find any signs of life, we moved on."
Kajander stands by his original assertion that nanobacteria are life forms. However, he blames himself for getting researchers hung up on the life question by using the name "nanobacteria."
"Calcifying self-propagating nanoparticles would have been much better," he wrote in an e-mail to Wired News.
But he added that his regrets about the name don't change the fact that nanobacteria have "miraculous" properties. Those include a growth cycle that closely matches typical biological cycles, the ability to form a shell and the "presence of both mammalian and bacterial components."
It's these properties -- and the potential to save lives -- that keep researchers focused on nanobacteria.
In February, NASA's McKay and Nanobac's �ift�ioglu announced that they had observed nanobacteria growing at five times its normal rate after they placed it in an incubator that simulates the microgravity conditions of space. The findings mean astronauts may be at an elevated risk for kidney stones on long flights -- something NASA is extremely worried about in light of its new plans to send humans to Mars.
The findings could also add fuel to nanobacteria research by giving scientists a way to grow cultures faster.
"The trouble with studying nanobacteria is that trying to get enough material is very hard," said Lieske. "Trying to culture a lot of it takes time."
Indeed, nanobacteria particles double about once every three days. In comparison, typical bacteria double about every 20 minutes.
Lieske's group has continued to experiment with nanobacteria since its 2004 paper. Though he said the team is looking for evidence of DNA and RNA, he is cautious about saying whether he thinks the particles are alive or just an unknown form of crystal.
As a possibility, he offered a third option: The particles could be a form of archaea, a relatively new category of tiny organisms whose DNA is vastly different from that found in typical bacteria. Over the past two decades, archaea have surprised scientists by turning up in places where life was least expected, like in sulfurous lakes and hydrothermal sea vents.
Whatever the case, the Mayo Clinic team may publish a paper outlining new findings in about six months, according to Lieske.
The world may not be waiting, but a handful of faithful microbiologists certainly will.
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Bea Seibert
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Truthfinder
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Thanks Tree, Dave and Bea! I'll start reading.......
Tracy
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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Truthfinder
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Wow, this stuff is even implicated in stuff like Rheumatoid Arthritis, which makes sense when I think about it. And `vaccine contamination' is mentioned, which is a whole other topic of discussion.
Bea, what kind of test do they do for this - antibody tests?
Bea, that one Pubmed article you posted certainly sounded conclusive that this stuff is `alive'. I'm not sure if there is a connection to Bartonella - just that nanobacteria may be `related' or a cousin to Bart, I think.
Well, this has been quite the eye-opener. This really does open up a whole new realm of consideration when it comes to chronic illness or any illness where calcification is present.
Thanks so much for the information.
Tracy
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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