LymeNet Flash: Viral IgG titers

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Viral IgG titers

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Topic: Viral IgG titers

timaca
Frequent Contributor (1K+ posts)
Member # 6911

posted

I posted this for Scott, who had raised questions about whether or not IgG titers mean active infection (in viruses). This info is also posted on the viral testing thread.

Here is some interesting info from the Focus website about viral IgG titers:
VZV IgG:
http://www.focusdx.com/focus/1-reference_laboratory/search_frame.asp?searchOptionScope=2&S1=1&S2=1&test=&sp=41020&Keyword=41015#an_41020
Single titers >=1:256 are considered suggestive of recent or active infection.

(My titer was >=1:256)

And EBV:
http://www.focusdx.com/focus/1-reference_laboratory/search_frame.asp?searchOptionScope=2&S1=1&S2=1&test=&sp=40445&Keyword=40445#an_40445
This panel detects antibody responses to EBV which may suggest chronic infection. Specimens with titers above the reference ranges (see below) are suggestive of chronic or reactivated EBV infection. Titers within the reference ranges are due to past infection.
Reference Range
VCA IgG-IFA: 1:10-1:2560
VCA IgA-IFA: 1:10-1:80
EA (R + D) IgG-IFA: 1:10-1:320

Many cases of chronic EBV disease display elevated EBV titers. However, it is difficult to diagnose serologically due to the variations of antibody responses possible. The Viral Capsid Antigen (VCA) IgG appears immediately after primary infection and persists indefinitely, falling gradually with time unless restimulated as in reactivated infection or chronic disease. The VCA-IgA is considered an acute phase antibody and its presence at elevated levels may be related to chronic or reactivated EBV infection. Titers to EA are generally detectable at onset of acute primary disease and begin to fall in 3-6 months. However, many cases of chronic EBV disease display elevated EA titers.

(My VCA IgG was 1:5120)

I found it interesting that the lab website was actually stating that certain IgG values could be suggestive of active infection....

Best,
Timaca

[ 08. February 2008, 05:59 PM: Message edited by: timaca ]

Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005 | IP: Logged |

SForsgren
Frequent Contributor (1K+ posts)
Member # 7686

posted

Thanks much. Good info.

--------------------
Be well,
Scott

Posts: 4617 | From San Jose, CA | Registered: Jul 2005 | IP: Logged |

JRWagner
Frequent Contributor (1K+ posts)
Member # 3229

posted

Posts: 1414 | From Ny, Ny | Registered: Oct 2002 | IP: Logged |

JRWagner
Frequent Contributor (1K+ posts)
Member # 3229

posted

again...

JRW

Posts: 1414 | From Ny, Ny | Registered: Oct 2002 | IP: Logged |

AliG
Frequent Contributor (1K+ posts)
Member # 9734

posted

^

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006 | IP: Logged |

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