posted
I don't think I could tolerate being in treatment for Lyme and Co-Infections without having the I.V. glutathione.
I get a "detox drip," which is a modified Myer's Cocktail with glutathione added at the very end.
I also take precursors in supplement form that the body needs in order to make glutathione like, L-Glutamine, Cysteine, Glycine.
I tried going a number of weeks without the I.V.'s due to cost. And I did not do as well as when I have the I.V.'s.
While it doesn't completely eliminate my herxes and also does not completely eliminate the symptoms of existing infections, it is making a marked difference in how I'm feeling.
Anything I can do to bolster my body's weaknesses and help it to deal with the rigors of Lyme treatment is a good thing, IMO. So, for the moment, I'll continue with them.
Posts: 503 | From Maryland | Registered: Oct 2007
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posted
Sparkle, thank you for the Readisorb liquid liposomal glutathione link. That's the brand I'm using, which I got from my ND.
Sizzled, yes, the Readisorb glutathione is reduced l-glutathione. The good thing is that you don't have to get it administered by anyone. You just mix 1/2 to 1 teaspoon into a drink and get it down! It's not very yummy, which is why I put it in pomegranate juice mixed with cold herbal tea to help hide the taste.
Nutmeg
Posts: 386 | From WA state | Registered: May 2005
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
Tincup I am very happy that the glutothione worked so well for you.
Glutothione is produced in the body to detoxify many chemicals and endotoxins in the blood.
I have been looking into this for years.
My LLMD once had some left over Glutothione and he did about 4 IV treatments for me.
Unfourtunatelly I noticed next to nothing@!@@@
I notice more from the sauna.
There must be something more going on then just that one detoxing chemical in my case.
Its very sad but it has become my duty as a living and breathing human to get well!
Get well or die. Posts: 2905 | From New England | Registered: Sep 2004
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lymeHerx001
Frequent Contributor (1K+ posts)
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posted
Tincup I am very happy that the glutothione worked so well for you.
Glutothione is produced in the body to detoxify many chemicals and endotoxins in the blood.
I have been looking into this for years.
My LLMD once had some left over Glutothione and he did about 4 IV treatments for me.
Unfourtunatelly I noticed next to nothing@!@@@
I notice more from the sauna.
There must be something more going on then just that one detoxing chemical in my case.
Its very sad but it has become my duty as a living and breathing human to get well!
Get well or die. Posts: 2905 | From New England | Registered: Sep 2004
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posted
Has anyone else out there gotten very sick with Glutathione? Can't tolerate it? Does anyone understand why?
Anneke
Posts: 364 | From California | Registered: Sep 2005
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Siz said.. "So...if it is proven it doesn't absorb or benefit from oral transmission....WHY do they sell it in the stores?"
Hmmmmmmmmm????????
The same reason a chicken crosses the road. Because it can?
BAD Tincup! That wasn't a decent answer.. but truth is.. I don't know why. Wish I could answer that for you Sizzzzzzz... but since I can't... hopefully others can. I'd like to know too.
Lymeherx.. Thanks. I am glad it helped me... and sorry you didn't see much benefit. I wish we could explain it.
I am so tired right now.. but did you say something about the sauna... or did someone else?
I am sorry I can't remember. BUT.. I sweat too and like it hot... but it doesn't get me feeling nearly as good as this did. Don't get me wrong... sweating helps... very much.. but this added G stuff really did me well. But without the sweats... I would be REALLY rough.
Anneke...
I don't know that either. So sorry. But I would like to hear someone take a stab at it.
luvs2ride
Frequent Contributor (1K+ posts)
Member # 8090
posted
I would venture a guess that if the IVs did not have much effect then you probably are not deficient in it.
Annekke, you are the first person I have heard of having an adverse reaction. Perhaps you have adequate levels? Maybe a bad batch? How many treatments did you have and what was your reaction?
Sizzle, lots and lots are things are sold on the market that are ineffective.
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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luvs2ride
Frequent Contributor (1K+ posts)
Member # 8090
posted
BTW, some foods that aid the body in production of glutathione are:
Quoted from the article I posted earlier in this thread
Foods that are high in glutathione include horseradish and cruciferous vegetables such as cauliflower, broccoli, cabbage, kale, and brussels sprouts. Dietary supplements that have been demonstrated to predictably raise blood glutathione levels are the glutathione precursors whey protein,5,27,28 and N-acetylcysteine (in a dose of 1,800-2,400 mg daily),12 or (as mentioned above) glutathione itself (recommended dose, 1-2 grams daily). A prudent person would probably use a combination of these modalities.
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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posted
Anneke, did you get sick from IV or oral glutathione? I had a throat-closing reaction to the oral one. Well, I usually have a throat reaction to just about anything. Except chocolate. Jus' kiddin'.
One guess: that it has something to do with liver enzyme pathway involvement? Lyme doctors told me there are two phases for clearance, and glutathione is involved with the first one. Something about a sulfated first phase.
Guess I'll learn more about it when I see them again. In the meantime, I'm glad something's helping you, TC.
Posts: 13171 | From San Francisco | Registered: May 2006
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posted
if you cannot get the IV, do you think the cream or the capsules would help the herx too? which is better the cream or pills? thanks for any info Radha
Posts: 392 | From New York | Registered: Dec 2005
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sizzled
Frequent Contributor (1K+ posts)
Member # 1357
posted
YES!!!
"Lots and lots of things are sold on the market that don't do a thing."
Buyer beware!!
Posts: 4258 | From over there | Registered: Jul 2001
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luvs2ride
Frequent Contributor (1K+ posts)
Member # 8090
posted
So sizzie
Do you have specific experience with glutathione you want to share or are you just heckling again?
TC did not use OTC glutathione so what is your point here?
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
Raising Glutathione Levels Therapeutic Dosages A typical recommended dose of oral glutathione is 50 mg twice daily. However, as noted above, when glutathione is taken by mouth it is destroyed.2 Therefore, no matter what the dose, it won't make any difference.
It is possible that some glutathione may be absorbed if it is held in the mouth and allowed to dissolve, but this has not been well studied.3
A more promising method for raising glutathione levels in the body involves taking supplemental cysteine or antioxidant supplements. Evidence suggests that cysteine (often supplied in the form of whey protein, which is high in cysteine) can raise glutathione levels in people with cancer, hepatitis, or HIV.4-7
In addition, because vitamin C has overlapping functions with glutathione, vitamin C supplements may spare some of the body's glutathione from being used up, thereby increasing its levels in the body.8,9 The antioxidant supplement lipoic acid appears to raise glutathione levels as well.10-15
Other supplements that might raise glutathione levels include N-acetylcysteine,16-19 glutamine,20 methionine,21 and S-adenosyl methionine (SAMe).22
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Double edge sword:
Glutathione infusion *potentiates* glucose-induced *insulin secretion* in aged patients with impaired glucose tolerance.
IL 1 Beta esp....is impacting/blocking the insulin secreting cells...you will see WHY in a sec.
Glutathione = more insulin secreted = lower glucose levels, but then...to counter lower glucose levels (we need an ongoing supply of glucose too)....
Gluconeogenesis will kick in and the glucose (stored as glycogen) and amino acids stored in fat will occur...and then Bb will have the amino acids it needs to build its cell walls and glucose...
And back up goes glucose.
Glucose -> insulin -> glucagon
Insulin and glucagon maintain/control just the "right" amt. of glucose in our blood stream. Insulin lowers the amt. of glucose and then
glucagon stops insulin (secretion)which would drop the blood glucose level too far.
Glucagon is the brakes for insulin.
***Insulin (glutathione stimulates its secretion) ACTIVATES PFK...***
But...now the "Why":
***Bb is dependent upon PFK*** to do this:
glucose -> fructose.
Need to know this:
"In vitro, cytokines like interleukin-1-beta (IL-1-B) and tumour necrosis factor-alpha (TNF-A) inhibit insulin release and can destroy islet B-cells."
Once again...Bb is infecting and damaging our own DEFENSE cells (several of them) from the get-go and disrupts the signalling between the defensive cells.
The worse thing about Bb is not the fact that it is PFK dependent, but that it has a PKCD INHIBITOR.
Protein kinase C, delta form. Kinases transfer phosphate groups. Bb is INHBITING phosphate transfer.
If serine is not phosphorylated (add phosphate) this disrupts the HPA axis.
Cortisol up...DHEA(S) down.
And Bb is a happy camper.
Cortisol raises glucose levels and impacts the enzyme in (subsequent) mast cells that converts histidine to histamine.
Bb has zinc fingers = histidine and cysteine bound by zinc.
Amino acids are building blocks of proteins. In order to "undo" Bb's lipoprotein cell walls, we have to change/alter those amino acids protein chains. ROS primarily hits LA in Bb's cell wall.
DHA, EPA and CLA are OKAY and are needed, but LA is not a good idea to supplement. Bb USES LA as a building block...and that is what ROS (free radicals) hit.
Personally, I'd rather support my own defense cells by upping their "energy".
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
I just read about acetyl-glutathione in Dr. Singleton's book. This is from a link on his site:
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
According to Dr. med. Gerhard Ohlenschl�ger�, Glutathione should not be taken, but rather S-AcetylGlutathione, because it is much more stable and accesses our cells, whereas Glutathione can react as early as in the stomach, with other substances.
Additionally, taking S-AcetylGlutathione leads to no negative 'reverse-connections', i.e. our own production of Glutathione is in no way negatively influenced.
In progressive aging, the regenerating enzymes of the oxidised Glutathione are increasingly excreted.
Therefore, aging people (all ages) should have their Glutathione-levels measured and if necessary take a supplement.
Side-effects:
In some cases it can lead to a lack of trace-elements (check selenium and zinc levels) accompanied with a possible lack of magnesium and potassium.
In diabetics it can alter the amount of insulin required, so that a regular blood-sugar-test is required.
How high should the doses be?
This depends on the current lab tests and indications.
In diabetics the high blood-sugar-levels (Ketone-bodies) can react with Glutathione, making higher doses of S-AcetylGlutathione necessary.
A lab-test should be carried out at regular intervals.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Paul-Ehrlich Str. 40, 60596, Frankfurt am Main, Germany. [email protected]
Intracellular glutathione (GSH) plays an important regulatory role in the host response to viral infections.
Replenishment of intracellular GSH is a desirable yet challenging goal, since systemic GSH supplementation is rather inefficient due to a short half-life of GSH in blood plasma.
Further, GSH is not taken up by cells directly, but needs to be broken down into amino acids and resynthesized to GSH intracellularly, this process often being impaired during viral infections.
These obstacles may be overcome by a novel glutathione derivative S-acetylglutathione (S-GSH), which is more stable in plasma and taken up directly by cells with subsequent conversion to GSH.
In the present study, in vitro effects of supplementation with S-GSH or GSH on intracellular GSH levels, cell survival and replication of human herpes simplex virus type 1 (HSV-1) were studied in human foreskin fibroblasts.
In addition, in vivo effects of supplementation with S-GSH or GSH on HSV-1-induced mortality were studied in hr/hr mice.
In cell culture, viral infection resulted in a significant decrease of intracellular GSH levels. S-GSH efficiently and dose-dependently (5 and 10 mM tested) restored intracellular GSH, and this replenishment was more efficient than with GSH supplementation.
In mice, S-GSH, but not GSH, significantly decreased HSV-1-induced mortality ( P less than 0.05).
The data suggest that S-GSH is a suitable antiviral agent against HSV-1 both in vitro and in vivo, indicating that this drug may be of benefit in the adjunctive therapy of HSV-1 infections.
PMID: 14624358 [PubMed - indexed for MEDLINE]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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sizzled
Frequent Contributor (1K+ posts)
Member # 1357
posted
Thank-you, Alig!
So there ARE different 'glutathiones'.
Reminds me of the discussion about 'magnesium'.
Good discussion led to revealing many, many, many types of magnesium supplements and to which ones were the most absorbable/beneficial, etc.
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