And in a way, I suppose that I have been avoiding it all day despite my desperation for interpretation and advice.
I am so emotional right now... please bear with me.
Considering the ``forcible coercion'' employed in obtaining a SIGNED yet blank Igenex test form from their Ped Duck, we figured this was our only shot so we went all out...
Around $2700 later we have 12 pages for each fantastic kid. I will post them in the order of the pages except for the band 31 confirmation test which are the last pages but pertain to the WB.
Their blood was drawn on 9/9/08 and they have never been treated.
6 year old son: (Who in retrospect has had some symptoms since birth but not the same as my daughters' and only within past year mood, memory, learning changes.)
GENOMIC - B BURGDORFERI NEGATIVE PLASMID - B BURGDORFERI NEGATIVE *************************************
MULTIPLEX B. BURGDORFERI Sample: Whole Blood
Genomic - B burgdorferi NEGATIVE Plasmid - B burdorferi NEGATIVE ****************************************
B. MICROTI ANTIBODY G/M
B. microti, IgM < 1:20 TITER B. microti, IgG < 1:40 TITER
INTERPRETATION OF IgM AND IgG TITERS: < 1:20 IgM - Suggests no evidence of infection < 1:40 IgG - Suggests no evidence of infection ... *******************************************
HME PANEL monocytic
HUMAN MONOCYTIC IgM 1:40 TITER
HUMAN MONOCYTIC IgG <1:40 TITER
INTERPRETATION OF IgM and IgG Titers:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. 1:20 IgM or 1:40 IgG - 1:160 May indicate progression of disease and/or treatment. >1:160 May suggest disease states.
*****************************************
HGE PANEL granulocytic
HUMAN GRANULOCYTIC IgM <1:20 TITER HUMAN GRANULOCYTIC IgM <1:40 TITER
INTERPRETATION OF IgM AND IgG TITERS:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. ...
***************************************** B. HENSELAE ANTIBODY G/M
B. henselae IgM <1:20 TITER B. henselae IgG 1:40 TITER
INTERPRETATION: B henselae IgM Antibodies: Titers of < or = 1:20 should be considered negative.
B henselae IgG Antibodies: Titers of < or = 1:40 should be considered negative. ******************************************
BABESIA FISH - RNA POSITIVE
*****************************************
And here's my 4 year old - 5 at months' end - daughter: She has had more severe symptoms of... what ? since birth.
**31 kDa. IND **34 kDa. IND **39 kDa. + **41 kDa. +++
all other bands are: - **********************************
CONFIRMATION FOR WESTERN BLOT TEST.
IgG 31 kDa Epitope Test: POSITIVE
***************************************
Multiplex B. Burgdorferi Sample: Serum
GENOMIC - B BURGDORFERI NEGATIVE PLASMID - B BURGDORFERI NEGATIVE *************************************
MULTIPLEX B. BURGDORFERI Sample: Whole Blood
Genomic - B burgdorferi NEGATIVE Plasmid - B burdorferi NEGATIVE ****************************************
B. MICROTI ANTIBODY G/M
B. microti, IgM < 1:20 TITER B. microti, IgG < 1:40 TITER
INTERPRETATION OF IgM AND IgG TITERS: < 1:20 IgM - Suggests no evidence of infection < 1:40 IgG - Suggests no evidence of infection ... *******************************************
HME PANEL monocytic
HUMAN MONOCYTIC IgM 1:20 TITER
HUMAN MONOCYTIC IgG <1:40 TITER
INTERPRETATION OF IgM and IgG Titers:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. 1:20 IgM or 1:40 IgG - 1:160 May indicate progression of disease and/or treatment. >1:160 May suggest disease states.
*****************************************
HGE PANEL granulocytic
HUMAN GRANULOCYTIC IgM <1:20 TITER HUMAN GRANULOCYTIC IgM <1:40 TITER
INTERPRETATION OF IgM AND IgG TITERS:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. ...
***************************************** B HENSELAE ANTIBODY G/M
B henselae IgM <1:20 TITER B henselae IgG 1:40 TITER
INTERPRETATION: B henselae IgM Antibodies: Titers of < or = 1:20 should be considered negative.
B henselae IgG Antibodies: Titers of < or = 1:40 should be considered negative. ******************************************
BABESIA FISH RNA POSITIVE
***************************************** Please, Please tell me that my Lyme brain has misinterpreted these results.
I've only had 2 months to learn about all of this. I am so confused - what does all this mean ?
Am I reading this right?
Both my children may have Human Monocytic Ehrlichiosis ? Or had ?
How is that treated?
They both tested positive for Babesia but not titers only via this FISH method which an LLMD called "experimental" today.
How/why is my son IgM Positive and IgG negative and my daughter the opposite: IgM negative and IgG Positive? Is there any signifigance to that?
Oh I give up - I need help.
THANK YOU !
Posts: 68 | From Pittsburgh | Registered: Aug 2008
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posted
Im not sure I can offer any advice other then talk to your llmd, and have him sit down and explain everything to you. If Im reading those test results correctly, it looks like lyme, and possibly some coninfections as well.
Perhaps the big question is...how are your kids acting? How are their symptoms? Its possible that they're symptoms fee, but test positive, and their bodies are fighting it off on their own.
You didnt say if you are seeing a llmd or not, or else I didnt see it. Anyway, have your llmd walk you through the test results, and then follow the recommened protocols for treatment.
Dont worry, its confusing at first, but once the explanations and treatments start, things will calm down.
Posts: 514 | From . | Registered: Apr 2008
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sixgoofykids
Honored Contributor (10K+ posts)
Member # 11141
posted
What I see is Lyme and Babesia (based on FISH test) for both kids. One is IgG positive, the other IgM. I don't think the IgM or IgG really makes a difference, it just means the test shows they were exposed.
In other infections, IgM would mean new infection. All it really means here is that there is Lyme .... Lyme can show IgM positive even when it's an old infection. IgM is actually more common than IgG.
The important thing now that you've established exposure is to look at their symptoms. Are they showing any?
It's easier to treat when they show few symptoms. My 15 year old daughter breezed through her 8 months treatment. She did herx, but during her first herx she went to a water park to play, so obviously they were much lighter than we usually see around here.
Lyme was not a huge deal for her ... big yes, she had big results .... her learning disabilities went away and so did her frequent headaches.
I would take them both to an LLMD for assessment. It looks like you're dealing with Lyme and babs. I didn't see any positive for erlichiosis.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Do either of your children have symptoms of Babesiosis?
I think it is possible to have a different strain of Babesia. MDL has a test for B.duncani, but there are many that there is no test for yet.
It seems the only drug really considered effective is Doxy, which is not recommended for children under 8. I believe it can cause severe discoloration of the forming teeth.
They say that chloramphenicol is sometimes considered as an alternative, but is associated with Aplastic Anemia.
I think they can both impact the immune response. Active co-infections can be one reason for screwy Lyme Western Blots.
Different people have different constitutions and immune strengths/weaknesses. Exercise, diet & sunshine can all effect our immunity, which is what the WB is measuring - our antibody response.
At times the antibodies can be bound up in immune complexes, which can cause a negative test when someone may be highly symptomatic.
Borrelia can change forms. They can make heat shock proteins. They can hide intracellularly. Whatever they happen to be doing at the time the blood is drawn can impact the results.
They are sneaky, tricky little buggers and any of those reasons could explain why your children have IGG vs IGM positives.
I would think that addressing the coinfections would be the first place to start.
If it were me, I would try to get my children to a doctor who is WELL-VERSED in treating these tick-borne diseases or willing to work with one.
There is a great need to understand all of the symptomology and the interplay of the co-infections to properly treat Tick-Borne Disease Complexes because the testing still leaves much to be desired and can not be relied upon conclusively.
You may want to call up Frank Pallone and ask him to get the bill for Lyme Research & Physician Education on the schedule for a hearing. (HR741) We need this YESTERDAY, and this is a perfect example of why.
No parent should have to be in this situation, with Pallone tying the hands of the people who would TRY to make a difference in the understanding of these diseases.
I'll keep you & your children in my prayers. I'm so sorry that you are going through this.
hugs & prayers, Ali
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Everyone's faster than me this morning.....I just saw the other responses.
The Ehrlichiosis IS unfortunately there in the results. The way they write that one up gave me some confusion when I was trying to read my OWN results.
I bolded what I'm looking at below:
quote: HME PANEL monocytic
HUMAN MONOCYTIC IgM 1:40 TITER
HUMAN MONOCYTIC IgG <1:40 TITER
INTERPRETATION OF IgM and IgG Titers:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. 1:20 IgM or 1:40 IgG - 1:160 May indicate progression of disease and/or treatment. >1:160 May suggest disease states.
quote: HME PANEL monocytic
HUMAN MONOCYTIC IgM 1:20 TITER
HUMAN MONOCYTIC IgG <1:40 TITER
INTERPRETATION OF IgM and IgG Titers:
<1:20 IgM - Negative for IgM antibodies. <1:40 IgG - Negative for IgG antibodies. 1:20 IgM or 1:40 IgG - 1:160 May indicate progression of disease and/or treatment. >1:160 May suggest disease states.
Is it safe to assume that neither child has been treated with Doxy or Chloramphenacol?
I think that there are very few instances when a physician would use these drugs in a young child.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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sixgoofykids
Honored Contributor (10K+ posts)
Member # 11141
posted
Ah, yes, you are right AliG.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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I am too tired to reply - been fighting w/ ducks & ins. co. all day long.
I am exhausted !
I'll be back tomorrow to clarify and answer a few questions. But wanted to say: THANKS !
Posts: 68 | From Pittsburgh | Registered: Aug 2008
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