-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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savebabe
Frequent Contributor (1K+ posts)
Member # 9847
posted
Definition of Lupus anticoagulants: Lupus anticoagulants are antibodies against phospholipids (substances in the lining of cells) that prevent blood clotting in a test tube. Persons with these antibodies may have an abnormally high risk of blood clotting.
Posts: 1603 | From ny | Registered: Aug 2006
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posted
If you know the exact name of the test I can tell you. When I first got sick a neurologist took a similar blood test where my anticardiolipin antibodies were high and she concluded I had "anti-phospholipid syndrome" and not any other disease.
Boy was she wrong.
Posts: 425 | From NY, United States | Registered: Mar 2005
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Have you had the whole hypercoag panel done from hemex? The Isac and the hypercoag panel #1?
That is where my hypercoag showed up. I am just wondering.
Have you started heparin yet? I am still doing it and have finally gotten accustomed to it. It can pack a mean punch a first so build up slowly and get your clotting and platelets monitored (I am sure your doctor knows this).
Posts: 588 | From Rhode Island | Registered: Jun 2006
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I was also tested for this at one time, it was negative. I was looking into it because in England a large number of people that were diagnosed with MS actually had this APS instead.
It doesn't always have a correlation with the disease Lupus from what I remember.
The website has a table that shows that 39% of lyme patients have these antibodies. (I wonder if that means they have elevated #'s of these antibodies...I showed some, but not high enough to be considered positive)
quote:Originally posted by Lymetoo: What's the name of the test??
Info needed.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Your serum levels of IgG4 antibodies is high, right?
Let me give you a comparison:
"The spirochete ***binds to*** heparan sulfate and dermatan sulfate on human epithelial (HeLa) cells (23) and to decorin, a dermatan sulfate/chondroitin sulfate proteoglycan associated with collagen fibrils."
and...
"The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay.
A patient with distal interphalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass.
These autoantibodies directed against the dsDNA conformation cross-reacted with ***chondroitin sulfate, dermatan sulfate and heparin***." PMID: 1917105
See the similarity?
"increased production of IgG4 may contribute to the pathogenesis of RA."
Good and bad...IgG4 looks to BLOCK Bb's attachment to B cells and fibroblasts and IgG4 is anti-inflammatory:
``Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange''
and:
"A LACK of IgG1 and IgG4 antibodies is related to toxic shock syndrome" (PMID: 3815898)
But...too much IgG4 -> this:
In diseases that elevate IgG4 (hyper IgG4):
"Histology from all 12 patients showed, to varying degrees, fibrosis, intense inflammatory cell infiltration with lymphocytes, plasma cells, scattered neutrophils, and sometimes eosinophilic aggregates, with venulitis and obliterative arteritis."
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Those like I said are basically the same test I had and coming from a rheumy he was checking for lupus?.. My PTT was also reactive but within normal range, expalin. I also believe it has to do with the hypercoag stuff.
Wouldn't it be great if we didn't have to ask a fellow/fellowee lymee what all these darn test mean and the docs ALL would take these tests to mean let's get these people healthy...and do our best so he/she understands how we are going to proceed...
-------------------- Raymond Leave the gun, take the cannolis Posts: 214 | From Rhode Island | Registered: Nov 2007
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quote:Originally posted by Raymond: Wouldn't it be great if we didn't have to ask a fellow/fellowee lymee what all these darn test mean and the docs ALL would take these tests to mean let's get these people healthy...and do our best so he/she understands how we are going to proceed...
My dr {LLMD} is not perfect, but he's pretty close to being that kind of doctor!
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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savebabe
Frequent Contributor (1K+ posts)
Member # 9847
posted
Thanks for the replies everyone. I am going to my llmd tomorrow with my new blood work in hand.
I am going to ask him to run further testing to get a clearer picture, so I will have to let everyone know what he did.
Thanks again.
Posts: 1603 | From ny | Registered: Aug 2006
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