Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Answer:
"individuals with R753Q were ***less responsive*** to infection by Borrelia burgdorferi, which causes Lyme Disease"
Question:
Now...what the heck is R753Q?
Answer:
The TLR2 polymorphism R753Q...
Ahhh...a "toll like receptor 2".
Question:
How does it function/what does it do?
Answer:
"TLR2 is the receptor for peptidoglycans, lipoteichoic acid, lipoarabinomannan, mycolylarabinogalactan, and zymosan."
(The above is Greek to me too.)
But...look at what anthrax does:
"Anthrax infection is thought to be partially mediated through the TLR2 pathway since
***TLR2 deficient mice are resistant to infection."***
"Toll-like receptor 2 also known as TLR-2 is a protein which in humans is encoded by the TLR2 gene.[1] TLR2 has also been designated as CD282 (cluster of differentiation 282).
TLR-2 plays a role in the immune system. TLR-2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and ***recognizes foreign substances and passes on appropriate signals to the cells of the immune system.***"
So it looks like we are more protected if our immune response to Bb is
OFF
i.e., if we don't have a lot of receptors to TLR2.
Hey, know what? I heard a doc talking about the current swine flu. He said like with SARS, the majority of deaths occurred in young healthy adults because ***they have the strongest immune response.***
He theorized that in the case of those flu(s)...sp?...what killed the young adults was too great an immune response!
So, if our immune response "ignores" the pathogen, and doesn't mount an enormous response, we stand a better chance.
Wow.
Here's some more food for thought:
"These observations suggest that at an early stage in infection,
lethal toxin may reduce (or delay) the immune response,
whereas at a late stage in infection, high titres of the bacterium in the bloodstream trigger
***macrophage lysis***
and the sudden release of high levels of NO and TNF alpha.
This may explain the symptoms before death, which resemble those of septic shock."
We know Bb "buys time" initially by picking up the SALP 15 protein from the tick's saliva and this protein interfers with calcium fluxes. (Bb sorta puts on an "overcoat" to fool our immune system.)
Then, once the overcoat is gone, Bb locks onto our plasminogen -> plasmin -> MMPs kick in and "pave the way".
These are destructive. The biggie is collagenase, though it looks like elastase is triggered too. Collagenase is MMP9.
"Interleukin-1B induces MMP-9 expression"
Remember, I've told you in the past, IL 1 B is really bad.
Now about Bb's toxin...Hey, I recovered my file...see my other post tonight.
This is all beginning to fall into place.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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adamm
Unregistered
posted
MArnie--so wouldn't our high levels of TNF-alpha and Th1 cells make swine flu worse for us?
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Look at how some of the natural anti-virals work. I linked it.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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randibear
Honored Contributor (10K+ posts)
Member # 11290
posted
ok, ya'll, dumb it down, please. what did you say??? LOL...
-------------------- do not look back when the only course is forward Posts: 12262 | From texas | Registered: Mar 2007
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disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
posted
Your posts always confuse me. LOL. I am too neuro to understand any of it.
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Adamm...go here and look at the impact of the "naturals" on TNF alpha:
Randi...the less we react to Bb, the greater chance we have.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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randibear
Honored Contributor (10K+ posts)
Member # 11290
posted
hmmm, in my confused mind...if we don't react to bp, then we wouldn't react to lyme, right?
-------------------- do not look back when the only course is forward Posts: 12262 | From texas | Registered: Mar 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Randi...Bb = borrelia burgdorferi, the spirochete that causes lyme disease.
What did you mean by: "if we don't react to bp"?
What's bp?
Look at it this way...the young adults who DIED in Mexico, died because it is believed
their immune response was too great.
Their hyperactive immune system may have destroyed too many of the viruse too fast -> way too many toxins released which triggered one heck of a FATAL "herx".
Follow?
P.S. Anthrax AND Bb both cleave (break apart) MAPKK-1.
[ 04-28-2009, 05:51 AM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Up...to see my P.S. above.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
I dont buy that I think anybody bitten with infected tick will get lyme
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
True! We don't react to the Bb because it is masked
by themselves having the ability to pick up the
cytoplasmic properties of our cells making them
invisible to our own immune defense. Good thing
they propagate slow. Are you saying in this virus
it is propagated so fast our systems crash from
the fight? This is strange. Especially in view of
the fact Lymies usually feel better in the
presence of an immune response, by any means,
whether it be from injury or illness.I would
think then
the easy fix for the virus would be to block the antihistamine
responses with benedryl, Sodium lavage to flush
the system, and support.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
It does seem that people relapse with Lyme after their immune systems are activated with things such as stress, the flu, a death etc. The question is..how do you stop this?
Posts: 74 | From Maryland | Registered: Dec 2008
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