Topic: Italy - Germany - and now the U.S. approach
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
In Italy, the goal of ICHT was to *increase ATP* by speeding up glycolysis and to burn fat (which was the original use for DNP i.e., immediate weight loss) which -> ketones.
In Germany, the goal of infrared therapy was also to *increase ATP* (adenosine triphosphate).
Now...in the U.S. there is another way to increase ATP.
Look closely at this:
"What Is Axona?
Axona is a formulation of caprylic triglyceride, a medium-chain triglyceride that is metabolized to ketone bodies,
predominantly b-hydroxybutyrate (BHB).
BHB in turn is metabolized to acetyl-coenzyme A (acetyl-CoA).
Acetyl-CoA enters the tricarboxylic acid cycle
leading to
*adenosine triphosphate production.*
Axona is metabolized to BHB in the liver.
BHB serves as an
alternate energy substrate
for neuronal metabolism.
BHB is known to cross the blood-brain barrier and enter the brain.
BHB is a common metabolic substrate that is normally produced by the body for neurons in starvation states where glucose is less available."
Axona is a new expensive "medicinal food" for Alzheimer's.
This takes TIME to work.
The tricarboxylic acid cycle = the citric acid cycle.
Caprylic acid is a component of virgin coconut oil.
In the liver, caprylic acid normally converts to a very unique HELPFUL ketone, BHB, which is known to "rescue" the cells depleted of specific nutrients.
Technically the process is called anaplerosis.
The supplement called Capryl by Solaray contains Ca as caprylate, ***Mg as caprylate*** and Zn as caprylate (according to the bottle). It does NOT contain Na...IMO, a good thing.
I often wondered why our liver was unable to help out.
This maybe why:
"TNF- and IL-6 Synergistically Inhibit Ketogenesis From Fatty Acids in (rat) liver cells."
"TNF- and IL-6 caused inhibition of ketogenesis from -ketoisocaproate and from octanoic acid."
Since OmegaBrite can lower the inflammatory cyotkines that are interfering with our liver producing ketones (esp. helpful BHB), perhaps children's doses of OmegaBrite alone can help children.
Now we use glucose to make ATP too, but in a jam, WE can use ketones.
While I have been very busy the past few months with personal things, I have also been working behind the scenes to try hard to bring this all together (with links) as time allowed.
I will post the information with links when it is completed.
To the best of my ability.
May God Bless you all with healing.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Man you have been busy. Thanks for the info. Could you break it down for suggestions for dummies like me.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
Quote: _____ I believe the cure is 2-fold: reduce the inflammation AND hit the infection.
Reducing inflammation maybe where OmegaBrite fits into the equation. It reduces the inflammatory cytokines. _____
Are the cytokines called TNFa, IL1B and IL6? Is there a blood test to test if these are high?
Thank you for sharing this.
Posts: 515 | From In His Loving Care | Registered: Apr 2009
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
"Now...in the U.S. there is another way to increase ATP."
So what is the "way" being used in the USA.
Marnie I am doing IPT. What is your feeling on that technique of treatment delivery?
Posts: 2747 | From Unites States Of America | Registered: Apr 2009
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
The "medicinal food", Axona, increases ATP.
The active component in it is caprylic acid.
But if inflammation is present and is impacting/harming the liver...caprylic acid may not be able to be converted to BHB.
Get the inflammation down!!!
OmegaBrite...it is very very unique.
IPT...insulin therapy to carry abx. into the cells.
Didn't work. Shantha, Atlanta.
Is he still trying that?
WHY?
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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springshowers
Frequent Contributor (1K+ posts)
Member # 19863
posted
Hi. I am interested in any ways to bring inflammation down. I totally agree with the inflamation factor.
So Omegabrite is one thing that helps?
What else do you recommend or have others had success with?
What does Shantha, Atlanta Mean?
IPT being done in many places across US and yes it is till being done and tried.
Posts: 2747 | From Unites States Of America | Registered: Apr 2009
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
posted
quote: Axona is a new expensive "medicinal food" for Alzheimer's.
Caprylic acid is a component of virgin coconut oil.
I went right for the coconut. I ate 2 to 3 ounces of coconut cream concentrate daily, and it put my body into ketosis.
The weight began to melt off. I did not change my diet or do any exercise.
This was all fine and good, but there was one annoying problem. The kidneys were working overtime, even when I was asleep. I'd go to bed, and wake up an hour or two later needing to void 24 ounces of urine. Ugh. Normal urine output when asleep should be about an ounce per hour.
As I lost weight, my hip and waist measurements went down a couple inches, but not the chest. My neck and throat looked better, as excess fat was reduced.
However, I stopped, and gradually gained it all back. As far as I can tell, my excess weight is due to metabolic reasons.
My brain fog, memory problems, and fatigue were not improved with this.
If you do try coconut oil, be aware that it affects the thyroid and your metabolism.
Carol
Posts: 6947 | From Lancaster, PA | Registered: Feb 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Only ONE ketone is vital...
BHB.
What did you do to reduce inflammation at the same time?
TNF alpha and IL 6 prevent caprylic acid from -> BHB in the liver.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Can you fool the body into thinking there is no inflammation. With something like benedryl or Zyrtec?
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Pinelady, I think we may try alternative means to *reduce inflammation* and to prevent IgE (allergic reaction...very dangerous) from kicking in.
But to simply get ONE cytokine down, like Humira for TNF alpha, isn't enough (my sis).
While Humira HELPS, it does not cure.
The cure is 2 fold...get all the cytokines down AND hit Bb.
Pinelady, I think this maybe what happened (and I can link all of this):
Bb first expresses OspA which triggers ROS (reactive oxygen species) -> oxLDL (oxidized low density lipoproteins) via macrophage (a white blood cell) activation of CB1.
OxLDL -> caspase 9 and then capase 3.
Caspase 3 cleaves MAGI-1 which is required for Rap 1 activation.
But CB2 Rap1 is needed to inhibit CB1 stimulated ROS production.
When Bb's OspA is oxidized, Bb changes his outer cell wall to OspB and the cell sends to the surface, a receptor called CB2 which works the opposite.
Agonists (helpers) of the CB2 receptor STOP INFLAMMATION. It is a call for help.
But by then our own antibody to CB2 is damaged (mAB CB2).
Bb was counting on that to survive. It needed to buy time.
In other words, we reacted first to Bb's OspA, but he changed "coats" on us -> OspB. By the time our system realized it, our own antibodies were "damaged" (mAB CB2). So we got stuck in an initial reaction. Ongoing inflammation and ongoing oxidative stress damage our DNA.
I'm working on seeing if this will work and how:
Conclusion CB1 promotes pro-inflammatory responses of macrophages through ROS production, which is negatively regulated by CB2 through Rap1 activation.
Blocking CB1 together with selective activation of CB2 may suppress pro-inflammatory responses of macrophages.
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