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Apparently all tetracyclines become highly toxic due to breakdown of chemicals when used past expiration date. Beware of ordering online for these unless you know for sure the vendor is not selling expired products! (See below):
Minocycline, like all tetracyclines, becomes dangerous past its expiration date. While most prescription drugs lose potency after their expiration dates, tetracyclines were known to become toxic over time due to the breakdown of certain chemicals present in the manufactured capsules. This is not a present concern in drugs manufactured in first world countries. Expired tetracyclines, as previously manufactured, can cause serious damage to the kidneys.
Minocycline's absorption is impaired if taken at the same time of day as calcium or iron supplements. Unlike some of the other tetracycline group antibiotics, it can be taken with calcium rich foods such as milk, although this does reduce the absorption slightly (by ~5%).
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