Topic: 2 brands of Lumbrokinase -- anyone know why doses are SO different? Best one?
minoucat
Frequent Contributor (1K+ posts)
Member # 5175
posted
I'm researching lumbrokinase for a friend, and I've come across two brands. I don't know why the LK amounts are so hugely different (20 mg/capsule vs 230 mg/capsule). The number of capsules recommended per day (3) is the same. The price is about the same. The type of lumbrokinase seems to be the same. Can anyone enlighten me?
What Allergy Research says about their brand (Canada RNA says they have the only original lubmrokinase with the validated research. ARG appears to disagree. ):
ARG: This is real Lumbrokinase. We obtain our Lumbrokinase from a pharmaceutical manufacturer, which supplies 85% of the Lumbrokinase used in China. Their Lumbrokinase is covered by the Chinese National Fundamental Health Insurance. The enzymes in our Lumbrokinase are standardized against urokinase and t-PA. Its fibrinolytic strength in plasmin units is 18�1.6 IU/cm2. Each capsule contains 300,000 IU.
Pharmacological and toxicity studies have been done. No negative effects of Lumbrokinase on the nervous, cardiovascular, respiratory or blood systems of rats, rabbits and dogs were recorded in acute and sub-acute toxicological experiments. Long-term animal toxicological experiments did not show any damage in hepatic and renal functions. No negative influences on embryonic development were found in embryonic rats, or any teratogenic or mutagenic effects. In clinical experiments, no undesired effects were observed in hepatic or renal function, blood levels of glucose or lipids, or other laboratory parameters. The LD50 has been established: LD50=144,600 U/Kg.
This Lumbrokinase material has been used in human studies, including Phase I, Phase II, and Phase III Clinical trials. There are published studies cited in PubMed that specifically used this material.
The starch that is listed as an Other Ingredient in our Lumbrokinase is made from corn.
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posted
any leads or links, hints or authors on the downside--inobviouscontraindications such as perhaps with blood thinners, for example to lumbrokinase?
Comparison Of Boluoke� (lumbrokinase) With Other Enzymes
One of the columns compares Boluoke to "Boluoke Immitators". Maybe this will give you some of the information you are looking for.
Boluoke is expensive. I've found it for less by searching online. If you PM me I'll send you the info.
Posts: 873 | From WA | Registered: Dec 2005
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posted
I use Boluoke. It's supposed to be the best....??
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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minoucat
Frequent Contributor (1K+ posts)
Member # 5175
posted
Yeah, I found that chart. Thing is, it doesn't appear to be accurate with reference to the ARG lumbrokinase. I'm not trying to compare other products that use different enzymes.
ARG says it does standardize against tPA and urokinase, it does give LD50, it does give the fibrinolytic activity, and it states it's lumbrokinase is the same stuff used in the human studies.
Measures are expressed in different units and so are difficult to compare.
ARG: fibrinolytic strength in plasmin units is 18�1.6 IU/cm2. Each capsule contains 300,000 IU.
Buluoke: Fibrinolytic strength in plasmin unit (CU): ~100 CU/g wet weigh
I've put a call into ARG but, because this is available through ARG supplies for medical professionals and not their Nutricology supplies for schmucks like me I dunno if they'll call back.
I'd really really really like to know what the difference is, and mainly whether you can get the same or better results using the ARG at 2 ARG pills a day (460 mg ARG lumbrokinase) as you would with Buluoke at 4 pills a day (80mg Buluoke lumbrokinase). (ARG recommends 4-6 pills a day for their product, , and I don't understand why the dosing discrepancy). If the ARG product is effective at the 2 pills a day I figured the MINIMUM savings at $130 over a two-month period (much much greater savings if you can't get the stuff on sale or buy in bulk).
This would make a huge difference in whether someone could actually take this for enough time to make a significant difference.
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posted
This would be very valuable to know the answer to. I'm not knowledgeable enough in this area to be much help, but I do hope someone can provide you with further info.
And a big THANKS for looking into this!!
Hopeful4
Posts: 873 | From WA | Registered: Dec 2005
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posted
I sure thank-you for your research. I'm counting pennies these days and a few dollars savings on the Boluoke would be awesome!
Bug
-------------------- Every experience God gives us, every person He puts in our lives, is the perfect preparation for a future only He can see....Corrie Ten Boom Posts: 343 | From Northcentral Iowa | Registered: May 2005
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posted
The starch that is listed as an Other Ingredient in our Lumbrokinase is made from corn.
I have been using lumbrokinase for a year and was not aware that corn was a filler. Most Americians are allergic to corn as it is genetically modified and stored in ways conducive to mold growth.
Thanks for the information.
Posts: 628 | From the south | Registered: Dec 2005
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minoucat
Frequent Contributor (1K+ posts)
Member # 5175
posted
serendipity -- I agree that the corn starch filler is a big disappointment -- can't understand why a company with "Allergy Research" in the title would use it.
The corn starch filler is NOT in the Buluoke brand.
Will let you all know if I uncover the mystery about the dosage.
-------------------- ********************* RECIDITE, PLEBES! Gero rem imperialem! (Stand aside plebians! I am on imperial business.)
Ever thought of contacting Allergy Research Group about your disappointment with the corn filler? They may appreciate the feedback. If you and others here are concerned about it, many other people may also be.
Just a thought. Hopeful4
Posts: 873 | From WA | Registered: Dec 2005
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posted
Hopeful-Thank your for reminding me that I can do more than be a passive bump on a log.
Monday I will call ARG. I have an account set up with them and order directly, so hopefully (no pun intended) they will consider my feedback.
Posts: 628 | From the south | Registered: Dec 2005
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minoucat
Frequent Contributor (1K+ posts)
Member # 5175
posted
OK, I talked to Hemex. Their rep said that the lumbrokinase they have the most experience with, and that they like to see people use, is Bulouke.
He also said that all lumbrokinase comes out of China. According to him the dosing difference is due to processing/quality control by the different companies after they receive the LK and when they make up their own products. Hemex's experience is that 20 mg of Buluoke was worth 230 mg (etc) of other lumbrokinase products. He did not make any claims of having verified this in the lab or having strenuously reviewed other products.
Haven't heard anything from ARG.
Re starch: Lymetoo, are you sure it was the Buluoke people you talked to? I didn't get hold of them but I did find their product catalogue and the only ingredients they list are lumbrokinase,gel, and polysaccharides from rice bran.
Here is the most inexpensive place for buluoke that I found: $69 per bottle (60 caps, or 15 days worth at 4 caps a day), or $55 per bottle if you buy at least 6 bottles at one time. Haven't bought from them yet, but I talked to them on the phone and they seem pretty sound. They've been around for a while.
posted
minoucat, I rotate/alternate the enzymes I take primarily to prevent becoming allergic to a product. So on even days I take lumbrokinase and odd days take Megaserrayzme. This keeps the cost down also.
Posts: 628 | From the south | Registered: Dec 2005
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Personally, I have found Boulke to be very effective.
I found I was allergic to Nattokaianse (Soy).
Good Luck!
Alexis
Posts: 38 | From Seattle, WA | Registered: Oct 2001
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minoucat
Frequent Contributor (1K+ posts)
Member # 5175
posted
I heard back from ARG. Their rep said:
"The miligram ammts show the weight of the capsule, including the starch. The LK vs starch ratio is proprietary. There is 150,000 units of fibrinolytic activity per capsule. The Beijing Bio Pharmaceutical Co. is the supplier, which supplies 65% of the market in China. This info is from 2004."
She said the fibrinolytic activity is important, rather than the exact amt of LK (due to variances in teh LK itself).
On paper and aside from what the Hemex folks say (and I do really respect their opinion and experience) the Fibrinase III seems to be equivalent to the Boluoke, aside from the starch issue. If you look for sale or bulk prices the cost is about equvalent, although the BioSciences Boluoke 6 for $55 each is really a great deal.
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