Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
The HPA (hypothalamus, pituitary, adrenal) axis is thrown off pretty fast in lyme disease....beginning with our "fight"...the adrenals. This impacts another axis..hypothalamic-pituitary-thyroid also.
Mg leaves the cells (muscle cells) at the outset of lyme in HUGE amts to try to INactivate HMG CoA reductase (prevent Bb's cell wall formation and prevent arteriosclerosis so the antibodies can REACH the pathogen).
Mg must also be "available" to help make antibodies, etc. When Mg leaves the muscle cells, this also looks to trigger a cell signal (call bell), NFkB, which is "yelling for" TNF alpha...inflammatory cytokine...upregulating the Th1 pathway...stimulating the bone marrow to produce WBCs which go to the thymus gland to "mature"...T cells.
Some of the WBCs stay around in the bone marrow to mature and become B cells...IL1 Beta. It appears. These are the "fighters" our body is chosing these to fight THIS infection.
It looks like the yelling is ongoing. We gotta get Mg back IN the cells to halt the cell "call bell". Na is displacing Mg as Na is needed to carry choline (which we know Bb wants) INTO the cells. So now we've got Na in the cell and K outside when the "flip" is healthier (more reactive K is supposed to be IN the cells)...and K might be healing...given the fact that Bb doesn't "like" KCL. Too much EXTRAcellular K and I bet you have "left sided" symptoms.
When Mg breaks from ATP and leaves the cell and with high sugar levels decreasing ATP production...less energy for transport of the "ions". There are a lot of pumps we must fix.
***We need more ATP. The oxygen route to making ATP is far, far more efficient. 2 nutrients critical to making ATP are: ribose and creatine. Ribose is also needed to make RNA which happens to differ from DNA in only one way...it contains an oxygen molecule.***
ATP controls the Na-K pump. And it also looks to drive Mg back IN the cells. That wouldn't make Bb happy. It prefers Mn. Enough Mg will displace Zn too...
Cortisol (from the adrenal glands) is being upregulated, impacting the pituitary, impacting the thyroid as well as the hypothalamus.
Cortisol overproduction looks to be a major problem.
High levels of cortisol suppress immune function, promote atherosclerosis, and damage and kill brain cells.
Cortisol has been described by antiaging doctors as one of the "death hormones" our body produces that causes premature aging. Cancer and AIDS patients have exceptionally high levels of cortisol production, causing severe immune suppression that often leads to death.
Why is cortisol up...several reasons...beginning with:
Norepinephrine is the 2nd major neurotransmitter in the body...the other is acetylcholine. It looks like norepinephrine rises to counter acetylcholine.
Sure...the immune system is in "overdrive". For good reason...too many antibodies are damaged due to a Mg deficiency (Mg and Ca are needed to make healthy antibodies), so the body has to find another way...make the entire body acidic. AND it has to counter all that alkaline glycogen (elevated blood sugar) which Bb is triggering via controlling/utilizing PFK...our rate limiting enzyme for glycolysis.
That's not so good. It is best to directly TARGET the pathogen. Prevent Bb's cell wall formation. Step one. INactivate HMG CoA reductase. Stop VLDL release. Get the nutrients needed for some cholesterol ('cause we must have it) from the GOOD fats. Increase the Omega 3s.
Now...here is another reason cortisol levels rise:
Alcohol increases cortisol levels. We know all spirochetes ferment sugar -> ethanol (alcohol).
What else raises cortisol?
Sleep DEPRIVATION raises cortisol levels (to counter, is the body making you sleepy?)
OVERtraining increases cortisol. I'm talking 45 minutes + of INTENSE exercise only! Moderate exercise is GOOD for us.
Low calorie diets increase cortisol.
Now...how do we lower it?
Vitamin C reduces cortisol. Hummm. Vitamin C looks to work with zinc (zinc lozenges are often this combination). Our thymus gland, the "seat of our immunity" needs zinc...but it looks like Bb favors it too? Calprotectin, in our neutrophils (most abundant WBC) bind zinc. I think yeast do too. When and if Bb is destroyed, the sudden "excess" zinc (which is toxic)likely stimulates ADDITIONAL "acids"/proteins to counter.
Acetyl L Carnitine REDUCES cortisol. Like I've said before...thank you Dr. Bruce Ames for Juvenon.
Phosphatidyl Serine REDUCES cortisol. I have read where 300mg per day (divided i.e., 100mg x 3 doses) restores the HPA axis. I have a bottle of NOW Phosphatidyl Serine in front of me. It also contains Ginkgo...60mg of that.
While Ginkgo is okay for MOST people, it is NOT okay for my son who has a genetic blood vessel problem (vertebral arteries are "extremely" small). These arteries cannot dilate, so Ginkgo (which looks to cause the blood vessels to dilate), for HIM, can trigger a seizure.
On the other hand, the Ginkgo in Pharmanex vitamins which my sis (with lyme) took, LOOKS to have helped HER to avoid "neuro" lyme symptoms.
Okay...enough for now...
Ancora Imparo. (I am still learning.)
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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luvs2ride
Frequent Contributor (1K+ posts)
Member # 8090
posted
Thank you Marnie for all your hard work.
Luvs
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
posted
Okay, I must be having a good day, because I could understand parts of this.
I am doing some of the stuff you recommend. Not Ginkgo, as that gives me continuous heartburn.
Thanks SO MUCH for this (and everything). My LLMD is very interested in this topic, and asked me to bring in any info I came across. I will take a copy to my next appointment.
monkeyshines
Posts: 343 | From Northern VA | Registered: Oct 2004
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