Screening of Indonesian Medicinal Plant Extracts for Antibabesial Activity and Isolation of New Quassinoids from Brucea javanica.Subeki , Matsuura H, Takahashi K, Nabeta K, Yamasaki M, Maede Y, Katakura K.
Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro.
Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, bruceantinol B and bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, bruceantinol, and yadanziolide A were isolated.
Antibabesial activities were also examined in vitro, and bruceine A and bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC 50 = 103 ng/mL) used clinically against B. gibsoni, with IC 50 values of 4 and 12 ng/mL, respectively.
PMID: 17896817 [PubMed - in process]
I'll be back but I'm out of time for now.
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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bejoy
Frequent Contributor (1K+ posts)
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posted
The question kind of confuses me because it's hard to draw the line between what is the result of any antibiotic treatment and what is the result of any other treatments.
Very few people go through lyme without ever being on antibiotics at all, even for something like a sinus infection.
It might be interesting to see a poll on success rates of people who used antibiotics with complementary treatments, and those who used antibiotics alone.
-------------------- bejoy!
"Do not go where the path may lead; go instead where there is no path and leave a trail." -Ralph Waldo Emerson Posts: 1918 | From Alive and Well! | Registered: Feb 2007
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Greatcod
Unregistered
posted
Let me clarify by asking how many people who had poor or no results with ABX treatment have been sucessful in using these other protocols?
I am not looking for a survey of Lymenet people but rather asking individuals who know these people to contact them and ask them to simply estimate their success rate. It's not science.
The names of the individuals are openly used here numerous times a day. No one has ever asked GiGi not to use Kilinghardt's name,and there is a current thread with Cowden's name in the title.
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TerryK
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posted
Please follow the rules and remove the last name. I don't recall seeing GIGI use the full last name but I usually ask people to remove it if I notice it.:
5. You also agree not to post the last name, or the first name, of any person that treats Lyme disease. Instead, please use the first initial of the last name only, with the state, but not city. For example, Dr. B. in NY. This person's contact information should not be displayed on LymeNet. However, you may email this information. This is to protect those that treat Lyme and the Lyme community
Thanks Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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Greatcod
Unregistered
posted
It seems to me that those doctors who have publicly authored protocols are in a different category, and have openly acknowleged they treat Lyme, going so far as to testify before Congess. Report me to the moderator if you must, and we can get a decision on these doctors' names. I have no problem with removing their names as long as that rule is consistently honored...including links to websites with their names.
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Truthfinder
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posted
Thanks for a very readable post, GC! Thanks for the extra effort you had to put into it.
I agree with Terry, GC. I think it's just a real bad habit for any of us to get into - posting any doc's last name that treats Lyme. I used to just do it for LLMDs, but any practitioner can become a target. So, I try not to do that anymore.
I'll see if there are any claims made by the author regarding success or failure in the Lyme/homeopathy book that I'm re-reading. He's definitely seen a number of Lyme cases in his endemic area in Germany - he says there are about 250,000 new infections there every year. So, I would tend to trust his knowledge and experience about this.
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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i would suggest trying the antibiotics, and if you dont get better, that is NO IMPROVEMENT or if you get worse, then try the alternatives.
what I do NOT reccomend is sticking to one or the other after years with no immprovement.
or maybe do both?
Posts: 615 | From maryland | Registered: Oct 2007
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Boomerang
Frequent Contributor (1K+ posts)
Member # 7979
posted
GC, I think this is a great question! It would be great if we had more info directly from the doctors and/or their patients.
Edited to add....I just did a search of Klinghart's name, and got a buch of results.
His name is even in the subject line of a lot of posts, so I don't see why it's an issue now?? Posts: 1366 | From Southeast | Registered: Sep 2005
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bejoy
Frequent Contributor (1K+ posts)
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posted
GC, thanks for the clarification about the question you are asking. In other words, antibiotic failures with success on alternatives. That question makes sense to me.
-------------------- bejoy!
"Do not go where the path may lead; go instead where there is no path and leave a trail." -Ralph Waldo Emerson Posts: 1918 | From Alive and Well! | Registered: Feb 2007
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D Bergy
Frequent Contributor (1K+ posts)
Member # 9984
posted
250,000 new cases a year in Germany alone?
Wow, I cannot even imagine what the real figures here are. I have had two more relatives get Lyme in the last year. This really has got to becoming a major epidemic, just from the amount of people I know personally that are infected, and a little extrapolation.
That makes Greatcods effort to try nail some of these things down even more important. There is likely going to be an explosion of new people here. It would be nice to have better answers than we have now.
D Bergy
Posts: 2924 | From Minnesota | Registered: Aug 2006
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TerryK
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posted
GC, As you've requested, I've asked for clarification from Jennifer.
Last I heard, my sister's doctor was being investigated for diagnosing lyme via a positive IgeneX WB - he is in the same State as Dr. K..
I personally think that it is important to protect our doctors if we are to keep the few remaining doctors that we have left.
As we've heard here, the waiting lists are getting longer and longer as we continue to lose our doctors.
It's such a small thing to ask. Please be considerate of other people and their need for a lyme doctor.
I do not believe that Dr. K. has a specific protocol named after him but I could be wrong. I have read a fair amount of his material and I haven't seen anything like that. Perhaps you are thinking of Dr. C??
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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Michelle M
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posted
quote:Originally posted by TerryK: Please follow the rules and remove the last name. I don't recall seeing GIGI use the full last name but I usually ask people to remove it if I notice it.:
Displaying Topics 1 - 50 (112 total) [More Matches] You searched for keywords: 'klinghardt'
(The other search modifier was GiGi herself -- although she did not author every thread, she started many, including many whose very title contains the full name of Dr. K.)
In my pre-lyme legal career, we used to call this "selective prosecution."
Michelle
Posts: 3193 | From Northern California | Registered: Apr 2005
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TerryK
Frequent Contributor (5K+ posts)
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posted
Thanks for pointing that out Michelle but just because it was done in the past does not mean that it is OK.
I am not a moderator (thank goodness) but I think it's important to protect our doctors and to that end, I'd like to know how we are expected to handle this situation.
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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Tincup
Honored Contributor (10K+ posts)
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
I just posted off topic stuff in the Medical Section.
I called people names.
I offered to sell stuff.
NONE of those things risk hurting my doctor or any LLMD who treats hundreds to thousands of others... and who couldn't if someone decides to be evil and take action.
Posting names CAN cause harm and it HAS caused harm .. believe it or not.
Please don't do it.
It isn't necessary.. and doing it annoys and frightens people .. and doing it risks lots more than you can imagine... and doing it breaks the rules.
Just because Johnny does it doesn't make it right for others to do.
Two wrongs don't make a right.
We aren't four year olds.
At least TRY to do the right thing and don't be argumentaive about it when asked nicely to please obey the rules.
Truthfinder
Frequent Contributor (1K+ posts)
Member # 8512
posted
Aren't Dr. K. and L. C. both ILADS docs?
And is there any violation if we refer to the MP (full name) or the Co***n Protocol? This can become a bit confusing when referring to specific protocols.
D Bergy, just to try to clarify the infection rate in Germany..... I'll quote from the book:
quote:``..... the contagion (borrelia) has since spread to all of Germany. This is verified by an official enumeration of recent infections, state by state, which (without considering the considerable number of unreported or false-negative cases) may lie around 250,000 instances per year.
``The region around Kraichgau in North Baden is most heavily affected with Hassler et al. finding fully 17% of the population infected. Regarding the official count, a statistical artifact arises in the fact that after the initial skin manifestations, the condition often continues untreated on a subclinical basis, only to break out under immunodeficient conditions months or years later with aggravated symptomology.''
So, my take on t his is that there are 250,000 people newly infected every year, but only a percentage of those become symptomatic immediately.
Also, it is interesting to note that the author says that......''in the majority of German states, there was no official obligation to report the disease until mid-2002''.
Okay, just wanted to make this clear.
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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luvs2ride
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posted
I can't believe we are arguing about whether or not to follow the lymenet rules.
Good Grief Charlie Brown!
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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