Department of Neurology, Ludwig-Maximilians University, Marchioninistr. 15, D-81377, Munich, Germany.
This review describes the current knowledge of the pathogenesis of acute Lyme neuroborreliosis (LNB), from invasion to inflammation of the central nervous system.
Borrelia burgdorferi (B.b.) enters the host through a tick bite on the skin and may disseminate from there to secondary organs, including the central nervous system.
To achieve this, B. b. first has to evade the hostile immune system. In a second step, the borrelia have to reach the central nervous system and cross the blood-brain barrier.
Once in the cerebrospinal fluid (CSF), the spirochetes elicit an inflammatory response.
We describe current knowledge about the infiltration of leukocytes into the CSF in LNB. In the final section, the mechanisms by which the spirochetal infection leads to the observed neural dysfunction will be discussed.
In conclusion, this review will construct a stringent concept of the pathogenesis of LNB.
PMID: 18097481 [PubMed - as supplied by publisher]
PMCID: PMC2148032
[ 16. February 2008, 06:13 AM: Message edited by: AliG ]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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bettyg
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posted
ali, i didn't see a date on this; is this new or OLDER stuff? thx!
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AliG
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posted
Sorry Betty,
I had missed the date. I went back & fixed it. Thanks for pointing that out.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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klutzo
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Member # 5701
posted
I don't know if it is just my brain damage, but this is confusing to me.
Assuming that most FMS is really Lyme,(which I do) and knowing that they have proven over and over that FMS is not inflammatory, how can Lyme be inflammatory?
Klutzo
Posts: 1269 | From Clearwater, Florida, USA | Registered: May 2004
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shazdancer
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posted
Nice, Ali, I caught that. You can read the entire version in Pub Med Central.
Keep an eye on PubMed Central in the coming year. In a new law signed at the end of last year, Congress is requiring that anyone who has used government funds to underwrite their research publish in open access within a year of publication. Most of the articles in the medical field should wind up in PubMed Central.
-- Shaz
Posts: 1558 | From the Berkshires | Registered: Jul 2001
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AliG
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Member # 9734
posted
Thank you so much for pointing that out Shaz!
I completely missed the link to the full article. At a quick glance, it looks like a must read.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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posted
Klutzo -- I've wondered about that, too. My understanding is that the inflammation occurs in the nervous system itself (and many can attest to the fact that lyme has inflammatory properties thoughout the body at times!) but that the muscle and connective tissue pains with "FMS" aren't inflammatory in the same sense that say, a sprain is inflammatory, or even some forms of arthritis. The inflammation occurs differently in the CNS, I think, and therefore FMS doesn't respond to NSAIDS and such.
Not much of an answer, I guess, but that is how I've made sense of it.
I, too, believe FMS is generally due to Lyme, or perhaps other infectious agents.
-------------------- "Looks like freedom but it feels like death.. It's something in between, I guess"
Leonard Cohen, from the song "Closing Time" Posts: 822 | From California | Registered: Jan 2006
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