treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
One entry found for lymphocyte.
Main Entry: lym�pho�cyte Pronunciation: lim(p)-f - s t Function: noun : any of the colorless weakly motile cells that originate from stem cells and differentiate in lymphoid tissue (as of the thymus or bone marrow), that are the typical cellular elements of lymph, that include the cellular mediators of immunity, and that constitute 20 to 30 percent of the white blood cells of normal human blood -- see B CELL, T CELL
Figure 1. Micrographs revealing attachment to and invasion of lymphocytes by Borrelia burgdorferi. Cultured SKW 6.4 cells and primary human peripheral B cells were coincubated with virulent or attenuated B. burgdorferi for 1 hour; the mixtures were then prepared for and examined by light or electron microscopy. The micrographs are representative of each susceptible host cell population. a: Light microscopy revealed attachment of spirochetal tips to SKW 6.4 cells; attached spirochetes remained highly motile yet anchored to host cells. b: Scanning electron microscopy revealed that adherent spirochetes penetrated lymphocytes through endocytotic pits; penetrated lymphocytes exhibited a noticeable loss of filopodia and other surface projections. c: Transmission electron microscopy showed that intracellular spirochetes were retained within vacuoles; no fusion of lysosomes to endocytotic vacuoles was observed. d: Continued coincubation with virulent spirochetes resulted in numerous lymphocytes with disrupted cell membranes. e: No such cytopathic changes were observed with uninfected control lymphocytes. No such cytopathic changes were observed with lymphocytes incubated with Borrelia hermsii or attenuated B. burgdorferi
Killing of Lymphocytes by Spirochetes
FIG. 1. Attachment of B. burgdorferi to primary murine lymphocytes. Scanning electron microscopy of coincubation mixtures containing B. burgdorferi and immunomagnetic bead-purified lymphocytes (L) showed that spirochetes (S) adhere to immobilized cells but not to the antibody-coated beads (B). Examination of paired stereomicrographs showed that attachment occurred at variable locations along the axis of the spirochete. However, adherence was observed most frequently in association with the terminal ends of filopodia extending from the surface of immobilized lymphocytes. Scale bar, 0.5 �m.
Especially relevant to me today...just this morning I was searching for answers to why I am so sore on the right side under my arm- and trying to educate myself on the effect of Lyme on the lymphatic system.
Since being infected with Lyme in October and starting treatment just over a month later( 400 mg of doxy/day with various supplements)- I have had times where I am sore under the arms and in the groin.
I had a bit of a scare with a breast lump which after ultrasound and mammogram looks to be a cyst- perhaps also related to the lymphs?
I have read that Bartonella can affect the Lymph more than Lyme- any ideas as to why?
Perhaps I only have Bartonella? This whole tick disease journey began with a "nip" from a tick and the only skin rash has been one round red bump on the same finger that got the nip....( which a Park Ave dermatoligist told me was perfectly normal-ARGH!-)
it is still there and red today actually- same side as my sore lymphs...
So many mysteries with Lyme disease- Why does it seem to affect one side of the body at a time for instance....?
Thanks for insight and ongoing wisdom-
Sarah
Posts: 25 | From New York | Registered: Nov 2004
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treepatrol
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Your welcome Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003
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could this cause my lymphocyte count to be low??? I have been trying to figure out what is wrong with me for the past 4 years and I recently looked through my medical records and found that I had high neutrophils, high eosinophils, and low lymphocytes on a number of occasions...I have also tested positive for lyme but the testing method I guess was questionable. So anyway, could this be a reason why my lymphocytes have been low, in some cases when I was most sick they were way low.
thanks
Posts: 99 | From California | Registered: Feb 2005
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treepatrol
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quote:Originally posted by ivebeentricked: could this cause my lymphocyte count to be low??? I have been trying to figure out what is wrong with me for the past 4 years and I recently looked through my medical records and found that I had high neutrophils, high eosinophils, and low lymphocytes on a number of occasions...I have also tested positive for lyme but the testing method I guess was questionable. So anyway, could this be a reason why my lymphocytes have been low, in some cases when I was most sick they were way low.
thanks
Yes from what I have been reading yes Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003
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My spinal tap results read "very rare lymphocytes" which I think means very low.
Posts: 128 | From Brick, NJ, USA | Registered: Dec 2003
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hiker53
Frequent Contributor (5K+ posts)
Member # 6046
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Kare,
Very rare lymphocytes in a spinal tap is a good thing. If you have white cells in your spinal fluid that means you have an infection, such as meningitis there.
The funny thing is that the Neuro and ID Drs did not mention the rare lymphochtes. They do not want to hear about LD. Is this an indicator of LD in the nervous sys? I definately do have big issues w/ my nervous sys.
Posts: 128 | From Brick, NJ, USA | Registered: Dec 2003
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I've been low too. But not dx with Lyme, yet.
Posts: 17 | From CT | Registered: Mar 2005
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janet thomas
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Tin cup- You never fail to crack me up- Thanks Janet
Posts: 2001 | From NJ | Registered: Mar 2005
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
up for fix
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