Topic: This is the one in Humans expression!! Vaccine 2007 OspC
treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
Vaccine. 2007;25(3):466-80(ISSN: 0264-410X Earnhart CG; Buckles EL; Marconi RT Department of Microbiology and Immunology,Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.
Lyme disease is the most common arthropod-borne disease in North America and Europe. At present, there is no commercially available vaccine for use in humans. Outer surface protein C (OspC) has antigenic and expression characteristics that make it an attractive vaccine candidate; however, sequence heterogeneity has impeded its use as a vaccinogen. Sequence analyses have identified 21 well defined OspC phyletic groups or "types" (designated A-U). In this report we have mapped the linear epitopes presented by OspC types B, K, and D during human and murine infection and exploited these epitopes (along with the previously identified type A OspC linear epitopes) in the development of a recombinant, tetravalent, chimeric vaccinogen. The construct was found to be highly immunogenic in mice and the induced antibodies surface labeled in vitro cultivated spirochetes.
Importantly, vaccination induced complement-dependent bactericidal antibodies against strains expressing each of the OspC types that were incorporated into the construct. These results suggest that an effective and broadly protective polyvalent OspC-based Lyme disease vaccine can be produced as a recombinant, chimeric protein.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
yoooooohhhhhhooooooooooooooo
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
up
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Truthfinder
Frequent Contributor (1K+ posts)
Member # 8512
posted
But just the same.... who would volunteer to be a guinea pig to test it?
Would you, Tree (assuming there were no other barriers like already having Lyme)?
Tracy
-------------------- Tracy .... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�. Posts: 2966 | From Colorado | Registered: Dec 2005
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
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Yes I would as Long as they are using the right peptides. This is OspC the one that all warm blooded recognize
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
Hope they will be checking it to make sure it does not cause the same kind of problems that the OspA vaccine (LymeRix) caused.
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