SAN FRANCISCO (AFP) - In a dramatic case of microbial sleuthing, US scientists said they have discovered a new, potentially deadly strain of bacteria previously unknown to medicine.
The bacteria was found in a 43-year-old American woman who had traveled across Peru for three weeks and suffered from symptoms similar to typhoid fever or malaria. The woman has since recovered.
Named Bartonella rochalimae, the new species is a close relative of a microbe that sickened thousands of soldiers during the First World War with what became known as trench fever, spread through body lice.
It is also related to a bacteria identified 10 years ago during the AIDS epidemic in San Francisco as the cause of cat scratch disease, which infects 25,000 people a year in the United States.
It was this previous work on cat scratch disease related to AIDS that helped experts at the University of California San Francisco (UCSF) and the US Centers for Disease Control and Prevention isolate the new bacteria found in the female traveler.
The findings are published in the New England Journal of Medicine.
Two weeks after returning to the United States from her trip to Peru, the woman experienced potentially life-threatening anemia, a rash, an enlarged spleen, insomnia and a high fever that lasted for several weeks.
Her traveling companion did not fall ill.
The Peruvian Andes is home to a related bacteria, spread by sand flies, and at first this was what experts thought was causing her illness.
Further investigation indicated the culprit was a new species altogether.
The new discovery is the sixth species identified that can infect humans, said Dr. Jane Koehler, professor of infectious diseases at UCSF and senior author of the paper.
In 1987, Koehler encountered her first patient infected with Bartonella at the AIDS Clinic at San Francisco General Hospital.
"The bacteria were eating away a bone in the arm of an AIDS patient - for
months," Koehler said. "They can cause extremely painful lesions and tumors of blood vessels on the skin of immunocompromised patients."
In 1997, her team discovered that the Bartonella henselae bacterium causes cat scratch disease. Symptoms include swollen lymph nodes and fever after a person is scratched by a cat.
The new bacterium is treated with a different antibiotic that those used for cat scratch disease.
"When a patient has a high and persistent fever, we need to come up with the correct diagnosis and treatment as soon as possible - particularly for those with a weakened immune system, who can die from the infection," Koehler said.
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treepatrol
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Wasnt it or didnt Martin Fried, MD mention this a year or so ago in his video on lymediseaseassociation website????
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treepatrol
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quote:Originally posted by treepatrol: Wasnt it or didnt Martin Fried, MD mention this a year or so ago in his video on lymediseaseassociation website????
or was it Joseph Burrascano, MD.in 2005 in a video?
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treepatrol
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Check out the dates new huh??
Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease Brenner SA, Rooney JA, Manzewitsch P, Regnery RL. Isolation of Bartonella ( Rochalimaea ) henselae : effects of methods of blood collection and ...
Journal Article, Emerg Infect Dis, September 2006
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Treatment Preferences for Resuscitation and Critical Care Among Homeless Persons Med 1990; 150:2030-2035 Spach DH, Kanter AS, Dougherty MJ, et al. Bartonella ( Rochalimaea ) quintana bacteremia in inner-city patients with chronic ...
Journal Article, CHEST, June 2005
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Splenic Peliosis With Spontaneous Splenic Rupture: Report Of Two Cases parenchymal bacillary peliosis. This is due to secondary infection with Bartonella henselae and a similar organism, Rochalimaea henselae . [1,8] Both ... :::::::::::::
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Journal Article, BMC Surg, June 2006 Bug Vectors - Human Lice and Disease from Infections in Medicine � Trench Fever Trench fever, caused by Bartonella ( or Rochalimaea) quintana, is widespread in parts of Europe, Asia, ...
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Journal Article, Infect Med, October 2000 Research Focus - Musculoskeletal Manifestations of HIV Infection and stabilization may be required. [2] Bacillary angiomatosis Bartonella henselae, a gram-negative rod (previously known as Rochalimaea henselae ...
Journal Article, AIDS Read, February 2003
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treepatrol
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Bartonella quintana Characteristics and Clinical Management Microbes Infect. 2000;2:1193 205. Maurin M, Raoult D. Bartonella (Rochalimaea) quintana infections. Clin Microbiol Rev. 1996;9:273 92. Byam W, ...
Journal Article, Emerg Infect Dis, February 2006 Rodent-Associated Bartonella Febrile Illness, Southwestern United States Koehler JE, Quinn FD, Berger TG, LeBoit PE, Tappero JW. Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis. ...
Journal Article, Emerg Infect Dis, July 2006 Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease SA, Rooney JA, Manzewitsch P, Regnery RL. Isolation of Bartonella ( Rochalimaea ) henselae : effects of methods of blood collection and handling. J ...
Journal Article, Emerg Infect Dis, September 2006 Treatment Preferences for Resuscitation and Critical Care Among Homeless Persons 150:2030-2035 Spach DH, Kanter AS, Dougherty MJ, et al. Bartonella ( Rochalimaea ) quintana bacteremia in inner-city patients with chronic alcoholism. ...
Journal Article, CHEST, June 2005 Splenic Peliosis With Spontaneous Splenic Rupture: Report Of Two Cases Am J Clin Pathol 1979, 71(5):586-90 Slater LN, Welch DF, Min KW: Rochalimaea henselae causes bacillary angiomatosis and peliosis hepatis. Arch ...
Journal Article, BMC Surg, June 2006 Bug Vectors - Human Lice and Disease in Medicine � Trench Fever Trench fever, caused by Bartonella ( or Rochalimaea) quintana, is widespread in parts of Europe, Asia, Africa, Mexico, and ...
Journal Article, Infect Med, October 2000 Oral Cavity Lesions: Approach to Oral Cavity Lesions The oral cavity is a complex structure that plays a role in many important functions, including mastication, swallowing, speech, and respiration.
Clinical Review, ACS Surgery Online, November 2002 Pediatric Bulletin - Azithromycin and Cat-scratch Disease treatment were not achieved until this decade. Bartonella (formerly Rochalimaea ) henselae was identified as the etiologic agent of CSD in 1992 ( ...
Journal Article, Infect Med, August 1998 Research Focus - Musculoskeletal Manifestations of HIV Infection Bartonella henselae, a gram-negative rod (previously known as Rochalimaea henselae ), is the causative agent in the multisystem infection unique ...
Journal Article, AIDS Read, February 2003
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
treepatrol
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posted
quote:Originally posted by treepatrol:
quote:Originally posted by treepatrol: Wasnt it or didnt Martin Fried, MD mention this a year or so ago in his video on lymediseaseassociation website????
or was it Joseph Burrascano, MD.in 2005 in a video? rtsp://ldarm.webcastcenter.com/lda/lda_burrascano2005.rm
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
It's confusing because years ago, "Rochalimae" (named after discoverer) was sometimes used for genus instead of "Bartonella" - so you'd have Rochalimae henselae, Rochalimae quintana. Or they'd put it in parentheses, like Bartonella (Rochalimae) quintana.
Then they stopped using "Rochalimae" and everyone agreed to call the genus Bartonella. (B. quintana, B. henselae, etc.)
Now they discovered a new Bartonella species and decided to name the species after the discoverer of Bartonella, so it's called Bartonella rochalimae (B. rochalimae). A different species from Bartonella (Rochalimae) quintana.
(I don't know about the videos.)
[ 07. June 2007, 11:24 PM: Message edited by: ldfighter ]
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quote -- The new bacterium is treated with a different antibiotic than those used for cat scratch disease. -- end quote
Wonder what the antibiotic was?
Bea Seibert
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treepatrol
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According to Dr B he had great success with this unknown BLO {LEVAQUIN} Bartonella listen to his video.
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trails
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LD fighter--just to clarify or make even more murky -- Rochalimae is the "species" of Bartonella--they renamed it after the discoverer of this species.
looks like this research was done by a practicing clinical md---i might contact them shortly---will report back if i get anywhere. This doc has done lots of research with HIV and bart in the past.
the article also points out that this species of bart can be carried by the common flea.
Posts: 1950 | From New Mexico | Registered: Sep 2001
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quote:Originally posted by trails: LD fighter--just to clarify or make even more murky -- Rochalimae is the "species" of Bartonella--they renamed it after the discoverer of this species.
I think we're saying the same thing... for the new species just discovered, "rochalimae" is the name of the species ("Bartonella rochalimae"). But when you see the word "Rochalimae" in references from years ago with a capital "R", it refers to genus, not species (example - "Rochalimae quintana").
Capital R "Rochalimae" is equivalent to "Bartonella" and isn't used anymore. To make matters worse, some old references say things like "Bartonella (Rochalimae) quintana" - which isn't the new species, it's the same old thing as B. quintana.
(Why didn't they just pick a totally different name for the new species? )
trails, I'll be very interested to hear what this clinician/author has to say. If a flea can transmit bartonella spp. to humans after all, why isn't Wormser a little more concerned about tickborne transmission?
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treepatrol
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1: Eremeeva ME, Gerns HL, Lydy SL, Goo JS, Ryan ET, Mathew SS, Ferraro MJ, Holden JM, Nicholson WL, Dasch GA, Koehler JE. Bacteremia, Fever, and Splenomegaly Caused by a Newly Recognized Bartonella Species. N Engl J Med. 2007 Jun 7;356(23):2381-2387. PMID: 17554119 [PubMed - as supplied by publisher]
2: Wormser GP. Discovery of new infectious diseases -- bartonella species. N Engl J Med. 2007 Jun 7;356(23):2346-7. No abstract available. PMID: 17554115 [PubMed - in process]
3: Henn JB, Gabriel MW, Kasten RW, Brown RN, Theis JH, Foley JE, Chomel BB. Gray foxes (Urocyon cinereoargenteus) as a potential reservoir of a Bartonella clarridgeiae-like bacterium and domestic dogs as sentinels for zoonotic arthropod-borne pathogens in northern California. J Clin Microbiol. 2007 Jun 6; [Epub ahead of print] PMID: 17553970 [PubMed - as supplied by publisher]
4: Breitschwerdt EB. Bartonella species in blood of immunocompetent persons with animal and arthropod contact. Emerg Infect Dis. 2007 Jun;13(6):938-41. PMID: 17553243 [PubMed - in process]
5: Vassallo C, Ardigo M, Brazzelli V, Zecca M, Locatelli F, Alessandrino PE, Lazzarino M, Corona S, Lanzerini P, Benazzo M, Fabbi M, Borroni G. Bartonella-related pseudomembranous angiomatous papillomatosis of the oral cavity associated with allogeneic bone marrow transplantation and oral graft-versus-host disease. Br J Dermatol. 2007 Jun 6; [Epub ahead of print] PMID: 17553040 [PubMed - as supplied by publisher]
6: Fu J, Muttaiyah S, Pandey S, Thomas M. Two cases of endocarditis due to Bartonella henselae. N Z Med J. 2007 Jun 1;120(1255):U2558. No abstract available. PMID: 17546106 [PubMed - in process]
7: Scolfaro C, Leunga GG, Bezzio S, Chiapello N, Riva C, Balbo L, Bertaina C, Tovo PA. Prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease. Eur J Pediatr. 2007 Jun 1; [Epub ahead of print] PMID: 17541640 [PubMed - as supplied by publisher]
8: Casolari C, Pecorari M, Balli F, Fabio G, Gennari W, Sabbatini AM, Nanni N, Migaldi M, Guaraldi N, Tagliazucchi S, Alu M, Bertoli G, Fabio R, Portolani M. Unusual concurrent detection by polymerase chain reaction of Bartonella henselae and parvovirus b19 in an immunocompetent child with erythema nodosum and hepatic granulomatous disease. Diagn Microbiol Infect Dis. 2007 May 25; [Epub ahead of print] PMID: 17532594 [PubMed - as supplied by publisher]
9: Boralevi F, Leaute-Labreze C, Lepreux S, Barbarot S, Mazereeuw-Hautier J, Eschard C, Taieb A; Groupe de Recherche Clinique en Dermatologie Pediatrique. Idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases. Br J Dermatol. 2007 Apr;156(4):705-8. PMID: 17493068 [PubMed - in process]
10: Odenthal M, Koenig S, Farbrother P, Drebber U, Bury Y, Dienes HP, Eichinger L. Detection of opportunistic infections by low-density microarrays: a diagnostic approach for granulomatous lymphadenitis. Diagn Mol Pathol. 2007 Mar;16(1):18-26. PMID: 17471154 [PubMed - in process]
11: Wimmersberger Y, Baglivo E. Bartonella henselae infection presenting as a unilateral acute maculopathy. Klin Monatsbl Augenheilkd. 2007 Apr;224(4):311-3. PMID: 17458800 [PubMed - in process]
12: Vasquez T P, Chanqueo C L, Garcia C P, Poggi M H, Ferres G M, Bustos M M, Piottante B A. [Bacillary angiomatosis caused by Bartonella quintana in an human immunodeficiency virus positive patient.] Rev Chilena Infectol. 2007 Apr;24(2):155-9. Epub 2007 Apr 12. Spanish. PMID: 17453076 [PubMed - in process]
13: Biswas S, Raoult D, Rolain JM. Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis. J Antimicrob Chemother. 2007 Jun;59(6):1065-70. Epub 2007 Apr 21. PMID: 17449882 [PubMed - in process]
14: Takeda N, Ishiwada N, Fukasawa C, Furuya Y, Tsuneoka H, Tsukahara M, Kohno Y. [Pediatric pneumonia, pleural effusion, and pericarditis following cat scratch disease and serological cross-reactions among Bartonella henselae and Rickettsia japonica determined by indirect fluorescence antibodies] Kansenshogaku Zasshi. 2007 Mar;81(2):206-9. Japanese. PMID: 17447481 [PubMed - indexed for MEDLINE]
15: Vorou RM, Papavassiliou VG, Tsiodras S. Emerging zoonoses and vector-borne infections affecting humans in Europe. Epidemiol Infect. 2007 Apr 20;:1-17 [Epub ahead of print] PMID: 17445320 [PubMed - as supplied by publisher]
16: Eichhorn-Sens J, Bund T, Vogt PM. [Painfaul soft-tissue swelling of the upper arm.] Chirurg. 2007 Apr 19; [Epub ahead of print] German. PMID: 17443304 [PubMed - as supplied by publisher]
17: Gouriet F, Lepidi H, Habib G, Collart F, Raoult D. From cat scratch disease to endocarditis, the possible natural history of Bartonella henselae infection. BMC Infect Dis. 2007 Apr 18;7:30. PMID: 17442105 [PubMed - indexed for MEDLINE]
18: Woolley MW, Gordon DL, Wetherall BL. Analysis of the First Australian Strains of Bartonella quintana Reveals Unique Genotypes. J Clin Microbiol. 2007 Jun;45(6):2040-3. Epub 2007 Apr 11. PMID: 17428928 [PubMed - in process]
19: Manfredi R, Sabbatani S. Bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues. Braz J Infect Dis. 2006 Dec;10(6):411-5. PMID: 17420917 [PubMed - in process]
20: Chmielewski T, Podsiadly E, Tylewska-Wierzbanowska S. Presence of Bartonella spp. in various human populations. Pol J Microbiol. 2007;56(1):33-8. PMID: 17419187 [PubMed - indexed for MEDLINE]
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
trails
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posted
Yeah---we are saying the same thing, pretty much huh?
from what i understand, they named it after the R person again coz that person DID identify it, just that they mistook it for a whole new genus and not "just" a species of bart. so folks were trying to be nice and give credit, and they end up making everyone REALLLLLy confused.
Will be getting a referral to this doc. My own relapse of lyme was from black biting flies in Maine. I think she will be interested to hear my case. I have been encouraged by other docs of mine to see her. I am using the UCSF system for other ailments......we'll SEE! Posts: 1950 | From New Mexico | Registered: Sep 2001
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-- Rochalimae is the "species" of Bartonella--they renamed it after the discoverer of this species. ![[bonk]](graemlins/bonk.gif)
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