LymeNet Flash: Can Lyme & co-infections -> MS when EBV present?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Can Lyme & co-infections -> MS when EBV present?

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Topic: Can Lyme & co-infections -> MS when EBV present?

AliG
Frequent Contributor (1K+ posts)
Member # 9734

posted

Can Lyme & co-infections -> MS when EBV present?
Is re-activation of EBV the "trigger"?

Molecular Link between Malaria and Epstein-Barr Virus Reactivation - Can Babs do too?

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

ID of Epstein-Barr virus proteins as putative targets of the immune response in MS

Malaria + EBV = Burkitt's Lymphoma (?). Could that mean the combo takes down cancer fighting T-cells?

Could Babs + EBV = persistently low CD-57 counts?

[confused]

[ 04. July 2008, 12:56 PM: Message edited by: AliG ]

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Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006 | IP: Logged |

timaca
Frequent Contributor (1K+ posts)
Member # 6911

posted

Cpn can apparently lead to MS.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=10401775&dopt=AbstractPlus

Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005 | IP: Logged |

AliG
Frequent Contributor (1K+ posts)
Member # 9734

posted

Very interesting.
Thanks for the link Timaca! [Big Grin]

How are you doing lately?

Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis.

Sriram S, Stratton CW, Yao S, Tharp A, Ding L, Bannan JD, Mitchell WM.

Department of Neurology, Vanderbilt School of Medicine, Nashville, TN, USA.

Our identification of Chlamydia pneumoniae in the cerebrospinal fluid (CSF) of a patient with multiple sclerosis (MS) led us to examine the incidence of this organism in the CSF from 17 patients with relapsing-remitting MS, 20 patients with progressive MS, and 27 patients with other neurological diseases (OND).

CSF samples were examined for C pneumoniae by culture, polymerase chain reaction assays, and CSF immunoglobulin (Ig) reactivity with C pneumoniae elementary body antigens.

C pneumoniae was isolated from CSF in 64% of MS patients versus 11% of OND controls.

Polymerase chain reaction assays demonstrated the presence of C pneumoniae MOMP gene in the CSF of 97% of MS patients versus 18% of OND controls.

Finally, 86% of MS patients had increased CSF antibodies to C pneumoniae elementary body antigens as shown by enzyme-linked immunosorbent assay absorbance values that were 3 SD greater than those seen in OND controls.

The specificity of this antibody response was confirmed by western blot assays of the CSF, using elementary body antigens.

Moreover, CSF isoelectric focusing followed by western blot assays revealed cationic antibodies against C pneumoniae.

Infection of the central nervous system with C pneumoniae is a frequent occurrence in MS patients.

Although the organism could represent the pathogenetic agent of MS, it may simply represent a secondary infection of damaged central nervous system tissue.

A therapeutic trial directed at eliminating C pneumoniae from the central nervous system may provide additional information on its role in MS.

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006 | IP: Logged |

timaca
Frequent Contributor (1K+ posts)
Member # 6911

posted

AliG~

I finished my course of valcyte and saw improvements in energy, brainfog and feeling more "well".

It was found that I had high antibody levels to Cpn, so I started on doxy recently. That gave me a significant herx, which I'm just now pulling out of.

So, more bacteria to kill off.

Timaca

Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005 | IP: Logged |

AliG
Frequent Contributor (1K+ posts)
Member # 9734

posted

I have an appt w/LLMD today. Hopefully we can address my EBV titers.

I had gone to another LLMD who ordered a zillion tests. I don't have the results back yet, but I think CPN may have been one of them. I'll have to check.

I also have to call & see if any results are in yet.

The fatigue, malaise & brainfog have been huge issues for me. I'm glad to know that your antiviral Tx helped with that.

I hope the Doxy will do the trick for you now. Do you know how long you'll be on it or are you "playing it by ear"?

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006 | IP: Logged |

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