Borrelia hermsii, a spirochete and an etiological agent of relapsing fever, was cultivated in modified Kelly medium. Studies of the action of penicillin on B. hermsii strain HS1 revealed the following: (i) the in vitro minimum inhibitory concentration and minimum bactericidal concentration of benzylpencillin for this strain were 0.4 and 3.1 nmol/ml (0.15 and 1.1 pLg/ml), respectively; (ii) the primary morphological responses at the minimum bactericidal concentration of benzylpenicillin were the formation of spheroplast-like structures and an increased number of small, membranous blebs; (iii) radioactive benzylpenicillin bound to five penicillin-binding proteins in the whole cells of B. hermsii. The 50% binding concentrations of labeled penicillin for the five penicillin-binding proteins were within a factor of five of the minimum inhibitory concentration. More than onehalf of the total bound labeled penicillin was associated with penicillin-binding protein 1, the penicillin-binding protein with the largest apparent molecular weight (90,000).
Basicaly your sending Bb into its other forms not killing all just hybernation
The aim of this study was to investigate the morphological changes of Borrelia burgdorferi associated with penicillin treatment. An isolate of B. burgdorferi from an erythema migrans lesion was cultivated in BSK II medium and exposed to increasing concentrations (0.0625 mg/l-2 mg/l) of penicillin G for 5 days. The in vitro minimal inhibitory concentration (MIC) was determined to be 0.5 mg/l by broth dilution method. The morphological structures of untreated spirochetes, as well as their characteristic ultrastructural changes when exposed to penicillin, were observed by electron microscopy. The following alterations were discovered: (i) Numerous outer sheath blebs at a penicillin concentration of 0.0625 mg/l. (ii) A characteristic irregular waveform of the borrelial cells and complete loss of the outer sheath at a penicillin concentration of 0.125 mg/l. (iii) The presence of "spheroplasts" at the same concentration. (iv) Structural changes of the protoplasmic cylinder complex which showed an irregular pattern at a penicillin concentration of 0.125 mg/l. (v) Disruption of the protoplasmic cylinder complex into several parts at penicillin concentrations of 0.25 mg/l and 0.5 mg/l. (vi) Severe cytolysis at penicillin concentrations of 1 mg/l and 2 mg/l.
PMID: 7698837 [PubMed - indexed for MEDLINE]
wikipedia: Variants in clinical use The term ``penicillin'' is often used generically to refer to one of the narrow-spectrum penicillins, particularly benzylpenicillin.
[edit] Benzathine benzylpenicillin Benzathine benzylpenicillin (rINN), also known as benzathine penicillin, is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo. It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2-4 weeks after a single IM dose. It is marketed by Wyeth under the trade name Bicillin L-A.
Specific indications for benzathine pencillin include: (Rossi, 2004)
Prophylaxis of rheumatic fever Early or latent syphilis
[edit] Benzylpenicillin (penicillin G)
Penicillin G (Benzylpenicillin) 3D-model of benzylpenicillinBenzylpenicillin, commonly known as penicillin G, is the gold standard penicillin. Penicillin G is typically given by a parenteral route of administration because it is unstable to the hydrochloric acid of the stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity.
Specific indications for benzylpenicillin include: (Rossi, 2004)
Bacterial endocarditis Meningitis Aspiration pneumonia, lung abscess Community-acquired pneumonia Syphilis Septicaemia in children
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
I noticed you have it all down correct about the penicillins. I am now on the bicillin cr. I was a while back on the LA. I began to get like purple lumps from the LA. A lyme dr. I went to briefly said it then wasn't doing anything..nurse was probably ramming it in too fast as it is a lot thicker than the cr. This lyme dr. I'll tell you I got diagnosis of Lyme d. and vasculitis and dropped me like a hot potato as her tests came back negative for me. MDL labs. Really takes the cake is a member or was head of can't remember now LDSA maybe. What meds are you on..thanks.
Posts: 35 | From PA | Registered: Nov 2007
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poppy
Frequent Contributor (1K+ posts)
Member # 5355
posted
You noticed this is a very old post? He does not come here anymore, so you will probably not get an answer from him.
Not clear on what you are saying about the doctor who dropped you. This was a lyme doc? And the negative test made the doc drop you? Don't know who LDSA is. You should probably tell the support groups in that state about your experience with the doctor. They need up to date info because patients ask for doc recommendations.
Posts: 2888 | From USA | Registered: Mar 2004
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