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» LymeNet Flash » Questions and Discussion » Medical Questions » How much artemisinin 200? 400? 800?

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Author Topic: How much artemisinin 200? 400? 800?
HEATHERKISS
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I've been taking 100mg 2x a day. I bumped it to 200mg 2x a day. Is that ok?

Just asking because I have diarehea.

Heather


Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
david1097
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I can;'t say because I don;t know... BUT i am taking 200 mg with each dose of atavaquone (2 or 3 times per day depending on which abx i am on). The effect initially seemed to be improved at the higher artiminisin dose so i stuck with it. Without artiminisin, the effect was poor.

No persistent stomach problems


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tickedntx
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My LLNP has me doing Artemisinin 100mg tid with weekly shots of Bicillin L-A 1.2mu/2ml.
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breathwork
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OK..well...here's my dosage...

I take 600mg twice daily....along with Ketek and tinidizole...

The artemisinin is based on Dr. K's information....and is not prescribed by Dr. S...my LLMD. He knows about it but is not the prescribing doc...


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HaplyCarlessdave
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Breathwork--
Are you really taking 80mg of artimisinin? That is a HUGE dose. As it is slightly toxic, it might be a good idea to research the subject a bit. Have others taken this much without long term problems? Especially at that dose, you should take a break from it after about 5 weeks. Are you taking garlic (pr alicin), too? Garlic seems t enhance the effect of the artimesia.
DaveS

quote:
Originally posted by breathwork:

OK..well...here's my dosage...

I take 600mg twice daily....along with Ketek and tinidizole...

The artemisinin is based on Dr. K's information....and is not prescribed by Dr. S...my LLMD. He knows about it but is not the prescribing doc...



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Linda LD
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HEATHERKISS,

You have to pulse artemisinin!!! It is really hard on your liver! Are you taking Milk Thistle?

Stop taking it after three weeks. I started it at the first of the month and then stopeed at three weeks. When the first of the next month came around and I took my zith and started the artemisinin again I went outside in the heat and got an awful rash on my rib cage. I think this was the bug dieing. Doc made me stop taking it--but I strt again at the end of July. And I WILL NOT BREAK OUT IN A RASH!

It is great stuff but please pulse--for your liver!


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HEATHERKISS
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Thanks for answering everyone.

Linda,

Yes I take a week break after 3 weeks on. Currently I'm not on milk thisle or pau de arco because I'm taking mepron and want the best absorbtion.

Heather


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tabbytamer
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quote:
Originally posted by HEATHERKISS:
Yes I take a week break after 3 weeks on. Currently I'm not on milk thisle or pau de arco because I'm taking mepron and want the best absorbtion.

Heather


What is the pau de arco for specifically?

------------------
Tabby


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breathwork
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No I'm not taking 80 mg...I'm taking 1200mg....which is 1.2 grams per day in a divided dose, as suggested by Dr. K in Seattle...

I use artemisinin from Allergy Research Group.

My liver function studies are normal.

Your stomach will produce an enzyme that breaks down artemisinin after about three weeks...rendering it ineffective. After three weeks it's suggested that we take a break for a week, then restart the artemisinin. Apparently this break stops the production of the offending enzyme.

Dr. K also suggests taking it with grapefruit juice to discourage the stomach from producing the enzyme that breaks it down.


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Mo
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I used Holley Pharmaceuticals.

If you call them, you can aksed for their published study on use of Artimisinin in treating Cancer and malaria.

From that, I extracted from the info, that the blood concentration level of Artimisinin drops precipitously after you are on it 3 days..to like 50% less!..

But, it only takes a 2-3 day break to be able to get maximum concentration in blood again upon restarting.

After reading the papers thoroughly (another interesting thing is they are working with treating Cancer by loading tissues with iron, and then using the high doses mentiones here, like 700mg..so the art may be attracted to the iron in tissue cells..if you want the Art to go to Red Blood cells..you lay low on iron when taking it...so it may be most attracted to the iron in the RBC's in blood, and not attracted to food or supplement particles in blood)

From the info, I decided to treat my refractory babesia (post 8 months mep/zith, 14 days Clinda/Quinine, and self applied Riamet)..
I decided I needed to finish it off in the blood...from wherever it was 'hatching' from..
so devised a protocol that I thought would best get it there, so as to lower the levels to the point where my immune system could handle it.

Some may need to treat tisue and blood...I couldn't say.

I did four days of the Maleria dose for my weight..
so: 100mg 3x a day

Then took a three day break, and went back on..
so on and so forth from there..for a few months.

(I still wonder if I should have just done three days on, 2 days off..also wonder if the dose could have been higher, but I figured the one effective in Maleria was good to try)

From what I read, it didn't make sence to take it the way it is normally prescribed..six weeks or even three weeks straight. But..I am not a Doc, just read allot and used it and tracked my symptoms and bloodwork.

(interestingly..I had fever rises for the first three days, that dropped on the fourth, which ro me illustrated the blood concentration drop off)

At that point, what did I have to loose? All protocols had failed, so I went a bit renegade on my own advise (but did inform my Doc)..and I wanted to maintain the progress from Riamet, which was clear, but not full resolve. I clearly had a drug resistant case after all the pharmaceuticals. Made for some strong and slippery parasites..I swear they were flexing their muscles at me..

I also took each dose with some fat..an avacado, or some cheese..something like that.

Tracking my fever...it seemed to be working, so just kept at it, and ate low or no iron foods in the days on Artimisinin.
It leaves the blood quickly when you stop it, I believe peak levels are like 2-3 hrs after you injest it.

I think it worked..this tx after I used Riamet first. No symptoms in a year's time.

I tried wrapping with an LL at one of the conferences about it (mine was very interested, but of course this was on my own advise and not prescribed by him)..
but I explained all this to another LL who treats babs, and I don't know how much mind I was paid..I think he just thought I was the silly singer at the conferance ..lol..

I think more people need to be studying Babs and Art and tweeking protocols based on the studies in other conditions..and the differences Babs has in disease sequele (sp?)

Mo

[This message has been edited by Mo (edited 28 June 2005).]


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HaplyCarlessdave
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quote:
Originally posted by HEATHERKISS:
I've been taking 100mg 2x a day. I bumped it to 200mg 2x a day. Is that ok?

Just asking because I have diarehea.

Heather


That is the same amount I was on. I did several sequences of it, over 5 months, and took breaks, as has been suggested by someone here. I was on atovaquone, too (as 'malarone), as well as loads of garlic. (and doxycycline, and probably clarithromycin, part of that time, too).
I felt the artimisinin was very good for repairing my GI system. So I wonder if that's really the cause of he diarrhea for you. Are you assiduous about the acidophilus?
You might try psyllium seed husk powder,. or perhaps yoghurt and green tea; in small amounts.
DaveS

,


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HEATHERKISS
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Hi Hapless,

I take 2 physilliums every day. I take acidophilis pills about 3x a week and eat plain no flavor yogurt 2x a week.

Tabby,

PAU D'ARCO DEEP CLEANSING
http:/www.planetaryformulas.com
has a few ingredients to cleanse waste products and environmental toxins in our blood.

Thanks everyone,
Heather


Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
HEATHERKISS
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I posted a pretty good post that didn't go thru. Dam.

hapless,
I take pysillium, acidophilis pills and yogurt.

Thanks Everyone for posting.

Tabby,
Pau D'Arco deep cleansing
is a variety of things to clean out toxins
http:/www.planetaryformulas.com

Heather


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James H
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Mo,

Your comments on how to use artemisinin WITH iron are intriguing.

We are using Artemisinin with Amoxicillin for our Lyme right now, and at much higher doses than are common. At 400mg 3x day everyday there have been no problems with liver enzymes or otherwise. I am sure absorbtion has dropped off, but is still enough to leave a noticeable bitter taste in one's mouth.

Of course everyone is different, and we aren't taking alot of other stuff with it.

Back to the comments about iron... people jumped all over me awhile ago for speculating Artemisinin might (plus amoxi) might kill Bb by reacting with incidental iron wastes, as it does with Malaria... because supposedly Bb do not NEED iron to survive in culture.

(Please feel free to share other theories about how it works, I am open minded.)

Your thoughts on how to interleave iron supplements and Artemisinin are interesting.

[This message has been edited by James H (edited 29 June 2005).]


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