LymeNet Flash: anyone know if clindamycyin IV crosses BBB?

This is topic anyone know if clindamycyin IV crosses BBB? in forum Medical Questions at LymeNet Flash.

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Posted by chainsaw joseph (Member # 6611) on :

I cant seem to find this info anywhere.Is Rocephin the best for penetrating?Thanks,Joe

Posted by achey (Member # 6284) on :

yes....Been on iv clinda alone and in combo with zith tinidazole and mino at different times since feb. Still continuing the journey, and making improvements.

Wish you well with your recovery!

Posted by lymeloco on :

Another name for clindamycyin is cleocin.
From what I read, it does not significantly cross the bbb.

Not that I think you have to worry, but it crosses into placenta and breast milk.

Posted by andie-ws (Member # 6116) on :

Dear Joe,

Clindamycin is not known for its ability to cross the BBB.

However, the penicillans, of which Rocephin is a latter generation, prevent bacteria from forming cell walls and penetrate the BBB well.

It can encouarage gallbladder sludging so some prefer Claforan because while similar, it doesn't cause that problem.

The "Cyclines", particularly 2nd and 3rd generation, are lipid soluable and as a result cross into the brain.

They are also good for killing cell wall deficient forms, ie; those that are hiding in our own cells.

In ascending order of ability to penetrate:

1) tetracycline
2) doxy
3) minocycline

Minocycline is an oral often used for "neuro" and some LLMDs think it penetrates the BBB the best of all.

From anecdotal reports, it can cause intense herxing and be very difficult to tolerate. Some suggest ramping up slowly.

Flaygl and Tinidazole (cyst busters)interfere with the functioning of single-celled organisms and are anti-protozoal. They cross the BBB.

Sulfa drugs, like bactrim, also cross the BBB.

Good luck

andie, jc & julie
lyme x 3

Posted by chainsaw joseph (Member # 6611) on :

Wow ,great to get some info on this,thanks all.Out of 4 years of orals I felt the best on cipro until it ate my tendons,wonder if it was penetrating the brain.I think Im going to push for Rocephin and just be nervous about my gallbladder.

Posted by Pocono Lyme (Member # 5939) on :

Dear Joe,

Out of all the orals I've taken, Cipro is giving me the best results so far, which to me indicates Bartonella since Cipro doesn't work on Lyme.

Cipro is used in cultures to suppress everything else from growing so the Lyme bacteria will grow.

I may be looking at IV Roc. also, but plan on continuing treatment for Bart. as causes CNS symptoms also.
Will be in touch. Maybe Rifampin would be an alternative to Cipro.

Posted by chainsaw joseph (Member # 6611) on :

Thanks Pocono,I did rifampin for about three months but the cipro was better for me,to bad I had the tendon problems.How long have you been on cipro?

Posted by Mathias (Member # 5298) on :

Florquinlones in general have good BBB penetration, hence all of the CNS warnings and side effects.

Posted by Pocono Lyme (Member # 5939) on :

Joe,

Just got back from LLMD appt.. After two months on Cipro, going to stop for IV Rocephin. If the symptoms return, that cleared with Cipro, I can restart it.

I guess I'll probably be joining that choleycystectomy club. I've had pain in that area for quite a while now, so if it's gallbladder issues, I'm sure the Rocephin will let me know.

I get the impression, you are ready for IV too as these neuro symptoms are the absolute worst.

Posted by chainsaw joseph (Member # 6611) on :

Ive been needing IV for 3 years now but getting treatment for this disease is a crime.The neuro stuff is horrible and my own brain tortures me,it all could have been avoided if the CDC and local docs did there job.