Clindamycin is not known for its ability to cross the BBB.

However, the penicillans, of which Rocephin is a latter generation, prevent bacteria from forming cell walls and penetrate the BBB well.

It can encouarage gallbladder sludging so some prefer Claforan because while similar, it doesn't cause that problem.

The "Cyclines", particularly 2nd and 3rd generation, are lipid soluable and as a result cross into the brain.

They are also good for killing cell wall deficient forms, ie; those that are hiding in our own cells.

In ascending order of ability to penetrate:

1) tetracycline
2) doxy
3) minocycline

Minocycline is an oral often used for "neuro" and some LLMDs think it penetrates the BBB the best of all.

From anecdotal reports, it can cause intense herxing and be very difficult to tolerate. Some suggest ramping up slowly.

Flaygl and Tinidazole (cyst busters)interfere with the functioning of single-celled organisms and are anti-protozoal. They cross the BBB.

Sulfa drugs, like bactrim, also cross the BBB.

Good luck

andie, jc & julie
lyme x 3

Out of all the orals I've taken, Cipro is giving me the best results so far, which to me indicates Bartonella since Cipro doesn't work on Lyme.

Cipro is used in cultures to suppress everything else from growing so the Lyme bacteria will grow.

Just got back from LLMD appt.. After two months on Cipro, going to stop for IV Rocephin. If the symptoms return, that cleared with Cipro, I can restart it.

I guess I'll probably be joining that choleycystectomy club. I've had pain in that area for quite a while now, so if it's gallbladder issues, I'm sure the Rocephin will let me know.