I have been on azoles, tini, flagyl, fluca and doxy for 4 months. during that time I usually have a grapefruit for breakfast, whole seeds and all.
I have read that some say grapefruit limits abx absorption.
Some say it incrreasaes abx effectiveness.
Gonna switch to lemons I think.
quai
Posted by quaicheng (Member # 8392) on :
Does anyone have accurate data on Grapefruit and abx???
quai
Posted by tickedntx (Member # 5660) on :
I have read that it is very important to avoid grapefruit while on antibiotics. I wish I could remember where I read it, or if it applies to all antibiotics or just some.
If I am remembering correctly, it may be that it's actually dangerous, as opposed to just reducing absorption, but please don't quote me.
Posted by duramater (Member # 6480) on :
The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.
Any medicines such as erythromycin, calcium channel blockers, flovent, and some azoles that use this enzyme pathway will result in a higher (and potentially quite dangerous) blood concentration as their processing will be inhibited in the liver.
Posted by WildCondor (Member # 434) on :
Grapefuit interacts with a great many medications so please be careful and check before you eat one or take the supplements, drink the juice etc.
Posted by daystar1952 (Member # 3255) on :
Seems I read somewhere that grapefruit was beneficial to take with artemisinin. Something to the effect that you could take it longer if you drank grapefruit juice with it...that it lessened some side effect? Anyone else hear this?
Posted by Areneli (Member # 6740) on :
Correct, don't mix these two. Grapefruit changes dynamic of absorbtion, and you cannot predict which way it would go. For example, it may rapidly increase drug blood level but also decreese the time it is elevated. So you may end up with toxic levels for a few hours and without cover for the next few hours after your regular dose of medicine.
Posted by quaicheng (Member # 8392) on :