I have been on azoles, tini, flagyl, fluca and doxy for 4 months. during that time I usually have a grapefruit for breakfast, whole seeds and all.
I have read that some say grapefruit limits abx absorption.
Some say it incrreasaes abx effectiveness.
Gonna switch to lemons I think.
quai
-------------------- "In spite of the ever increasing cost of living, it remains quite popular" S. Shackel Posts: 87 | From walla walla wa | Registered: Dec 2005
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posted
Does anyone have accurate data on Grapefruit and abx???
quai
-------------------- "In spite of the ever increasing cost of living, it remains quite popular" S. Shackel Posts: 87 | From walla walla wa | Registered: Dec 2005
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posted
I have read that it is very important to avoid grapefruit while on antibiotics. I wish I could remember where I read it, or if it applies to all antibiotics or just some.
If I am remembering correctly, it may be that it's actually dangerous, as opposed to just reducing absorption, but please don't quote me.
-------------------- Suzanne Shaps STAND UP FOR LYME Texas (www.standupforlyme.org) (Please email all correspondence related to protecting Texas LLMDs to [email protected] with copy to [email protected]) Posts: 977 | From Austin, TX, USA | Registered: May 2004
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The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.
Any medicines such as erythromycin, calcium channel blockers, flovent, and some azoles that use this enzyme pathway will result in a higher (and potentially quite dangerous) blood concentration as their processing will be inhibited in the liver.
Posts: 689 | From western MA (we say buttER and pizzA) | Registered: Nov 2004
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WildCondor
Unregistered
posted
Grapefuit interacts with a great many medications so please be careful and check before you eat one or take the supplements, drink the juice etc.
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daystar1952
Frequent Contributor (1K+ posts)
Member # 3255
posted
Seems I read somewhere that grapefruit was beneficial to take with artemisinin. Something to the effect that you could take it longer if you drank grapefruit juice with it...that it lessened some side effect? Anyone else hear this?
Posts: 1176 | Registered: Oct 2002
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Areneli
Frequent Contributor (1K+ posts)
Member # 6740
posted
Correct, don't mix these two. Grapefruit changes dynamic of absorbtion, and you cannot predict which way it would go. For example, it may rapidly increase drug blood level but also decreese the time it is elevated. So you may end up with toxic levels for a few hours and without cover for the next few hours after your regular dose of medicine.
Posts: 1538 | From Planet Earth | Registered: Jan 2005
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-------------------- "In spite of the ever increasing cost of living, it remains quite popular" S. Shackel Posts: 87 | From walla walla wa | Registered: Dec 2005
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