This is topic Received IGeneX Results, IgG and IgM Western Blot in forum Medical Questions at LymeNet Flash.


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Posted by gtennis07 (Member # 15265) on :
 
My sister was diagnosed with Lyme disease last year and is currently receiving treatment. As a precaution, I decided to test myself after feeling symptoms of headaches, joint pain, fatigue, and brain fog. I received results today and was negative by CDC and IGeneX guidelines but still had some + and IND bands.

For IgG:
Band 41: ++
Band 31,39: IND

For IgM:
Band 23-25, 58: +
Band 31,39, 41: IND

What do you guys think... any chance of me having Lyme? Thanks in advance for any responses and advice.
 
Posted by ByronSBell 2007 (Member # 11496) on :
 
You are positive for lyme disease. Start treatment soon.

Just one IND means the test is positive by LLMD standards.
 
Posted by chamade (Member # 11472) on :
 
I would treat and see how you respond - that 23-25 is pretty specific.
 
Posted by chamade (Member # 11472) on :
 
quote:
Originally posted by ByronSBell 2007:
You are positive for lyme disease. Start treatment soon.

Just one IND means the test is positive by LLMD standards.

I think that's going overboard...everyone would have Lyme then.
 
Posted by Lymetoo (Member # 743) on :
 
Hi there! Welcome!! If it were ME, I would definitely do a trial run of antibiotics and then retest.

Quite often, those IND bands will turn positive.

IND does mean a weak positive... so you can take it for that as well. Most LLMD's would definitely treat given those test results.

Be sure to read this:

Dr C of MO's Western Blot explanation:

http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=042077

From the above link:

"In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.

These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93.

This is true regardless of whether it is IgG or IgM..."

----------------------------------
From 2005:

"The significant antibodies, in my opinion, are the 18, 23-25, 28, 30, 31, 34, 39, 58, 66 and 93."

Your positive and IND bands are in bold. Be sure to read the above link. The important parts are in bold.

Following his explanation is an important discussion of band 41 you'll be interested in as well!

When to Suspect Lyme Disease
http://tinyurl.com/lx2pz

More info:
http://www.ILADS.org/

Wild Condor's Links and information:
http://wildcondor.com/lymelinks.html
 
Posted by Geneal (Member # 10375) on :
 
I wasn't lucky enough to know about Lymenet prior to Western Blot testing. [Frown]

Quest came back with one positive. IgM 23.

That and my symptoms led a duck to diagnose me.

You need to find a LLMD.

Remember, Lyme is a clinical diagnosis.

Hugs,

Geneal
 
Posted by Lymetoo (Member # 743) on :
 
Well... actually.. That test result is more positive than MY test was!

And yes, Lyme is a clinical diagnosis. I like to show the facts on the test for any doubters who don't want to rely on a clinical diagnosis.
 
Posted by antsettler (Member # 7236) on :
 
hi, in european evaluation you have a negative igg and a positive igm at 98% specifity (in 53% sensitivity criteria), tipical of neurologic species that develop less bands, the dude is the frcuent cross-reaction of ospC;

european evaluation of your bands:

31 is not considered;

41 is very important only if strong (+++) reaction in igm, is enough for a positive igm;

39 is very important band in igg and igm;

23-25 is very important band only in igm, but have a 5% false positive in healthy people, cross reaction with ebv, and others;

58 is a important band in igg but is not considered in igm

these indet results is the worse, but the posibility of have lyme exist, greetings
 
Posted by adamm (Member # 11910) on :
 
Treatment is certainly in order with results like those

and
symptoms.
 


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