Sorry if this is a redundant question, but certain things have crossed my mind on this subject. What if people with Lyme spirochetes just can't make a proper antigen presentation of key peptides?
It is well documented that individuals of certain HLA types, are more susceptible to certain disease conditions than others. Why can't a vaccine be created using pre-digested antigens from cells of [individual] capable of defeating Lyme spirochetes, and harvest the peptides to create vaccine? Just thinking out loud here. Microw
Posted by bettyg (Member # 6147) on :
anyone? bottom of page 2.
Posted by Lymetoo (Member # 743) on :
I have no clue, but you'd have to do some tall talking to convince me to take a Lyme vaccine.
Posted by Marnie (Member # 773) on :
They can't...esp. to Bb's OspB.
Google Pubmed. In the search window, type: borrelia OspB magnesium Mg
Fab = fragment.
Our antibody to Bb's OspB (outer surface protein B) is "damaged" and only adequate Ca (which we have plenty of) and Mg (which we don't) can restore the "health" of our own antibodies to Bb's OspB.
It takes Mg and Ca to MAKE antibodies. Fact.
It is believed this outer surface protein (OspB) is THE one that triggers longstanding...
A new vaccine is in the works. "They" (researchers) are really on the right track on that one, IMO. Brilliant idea!
I have posted about it here (several months ago).
Posted by microw (Member # 14702) on :
But what about th1 system? They could use pre-prepared peptides [to stimulate NK cells]. Once the action starts, then a whole complement cascade could take place [in theory]. The bacteria, cysts and anything else could be attacked full force. Actually, that could be die- off reaction times a hundred.
Posted by Marnie (Member # 773) on :
I know my response doesn't really address the poster's original question but I wanted to let you guys know about Mary Tocco...if you already don't know about her. She spoke at the Physician's roundtable in N.C last month and gave a very powerful and credible presentation on the dangers of vaccines....in general.
I also have recently met a molecular biologist who used to make vaccines. She told me that she knows what they put in them and would not voluntarily be injected
Posted by microw (Member # 14702) on :
That was a good read. I suppose the best way to deal with this disease is to "slowly" bring down the load of bacteria and components + co-infections before using any kind of aggressive therapy. That is the conundrum. If antibiotic therapy causes cyst formation and eventual resistance patterns, there is smaller chance of long term resolution.
Is there an organelle that can be targeted? What about the mechanism of cyst formation-is there an inhibitor molecule that can be exploited?
Sorry, thinking out loud again.
I am really interested in the work being done on ubiquitins and the proteasome complexes. There seems to be certain drugs that target these processes which trigger exponential apoptosis of weakly expressed MHC 1 cells. Since Lyme is generally a problem of parasitized cells, this is interesting stuff to follow.
Posted by Marnie (Member # 773) on :
I suspect someday the anti-toxin and "antibiotic" is going to be: