posted
Sorry if this is a redundant question, but certain things have crossed my mind on this subject. What if people with Lyme spirochetes just can't make a proper antigen presentation of key peptides?
It is well documented that individuals of certain HLA types, are more susceptible to certain disease conditions than others. Why can't a vaccine be created using pre-digested antigens from cells of [individual] capable of defeating Lyme spirochetes, and harvest the peptides to create vaccine? Just thinking out loud here. Microw
-------------------- microw Posts: 129 | From Toronto, ON Canada | Registered: Feb 2008
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posted
I have no clue, but you'd have to do some tall talking to convince me to take a Lyme vaccine.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
They can't...esp. to Bb's OspB.
Google Pubmed. In the search window, type: borrelia OspB magnesium Mg
Fab = fragment.
Our antibody to Bb's OspB (outer surface protein B) is "damaged" and only adequate Ca (which we have plenty of) and Mg (which we don't) can restore the "health" of our own antibodies to Bb's OspB.
It takes Mg and Ca to MAKE antibodies. Fact.
It is believed this outer surface protein (OspB) is THE one that triggers longstanding...
A new vaccine is in the works. "They" (researchers) are really on the right track on that one, IMO. Brilliant idea!
I have posted about it here (several months ago).
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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posted
But what about th1 system? They could use pre-prepared peptides [to stimulate NK cells]. Once the action starts, then a whole complement cascade could take place [in theory]. The bacteria, cysts and anything else could be attacked full force. Actually, that could be die- off reaction times a hundred.
-------------------- microw Posts: 129 | From Toronto, ON Canada | Registered: Feb 2008
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
daystar1952
Frequent Contributor (1K+ posts)
Member # 3255
posted
I know my response doesn't really address the poster's original question but I wanted to let you guys know about Mary Tocco...if you already don't know about her. She spoke at the Physician's roundtable in N.C last month and gave a very powerful and credible presentation on the dangers of vaccines....in general.
I also have recently met a molecular biologist who used to make vaccines. She told me that she knows what they put in them and would not voluntarily be injected
Posts: 1176 | Registered: Oct 2002
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posted
That was a good read. I suppose the best way to deal with this disease is to "slowly" bring down the load of bacteria and components + co-infections before using any kind of aggressive therapy. That is the conundrum. If antibiotic therapy causes cyst formation and eventual resistance patterns, there is smaller chance of long term resolution.
Is there an organelle that can be targeted? What about the mechanism of cyst formation-is there an inhibitor molecule that can be exploited?
Sorry, thinking out loud again.
I am really interested in the work being done on ubiquitins and the proteasome complexes. There seems to be certain drugs that target these processes which trigger exponential apoptosis of weakly expressed MHC 1 cells. Since Lyme is generally a problem of parasitized cells, this is interesting stuff to follow.
-------------------- microw Posts: 129 | From Toronto, ON Canada | Registered: Feb 2008
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I suspect someday the anti-toxin and "antibiotic" is going to be:
Gallium nitrate might be good for horses, but is too dangerous for us (kidney-wise)- orally.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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emla999/Lyme
Frequent Contributor (1K+ posts)
Member # 12606
posted
Marnie,
I would like to get your opinion about Gallium as a treatment for Lyme Disease.
From what I have read about gallium, it kills iron dependent bacteria/pathogens.
But since borrelia burgdorferi doesn't require iron would Gallium still be effective against Lyme Disease?
Would the borrelia burgdorferi bacteria mistakenly "pick up" Gallium for some reason or the other?
If so, then would the Gallium be able to kill the borrelia burgdorferi bacteria?
Posts: 1223 | From U.S.A | Registered: Jul 2007
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